Evolution of human papillomavirus carcinogenicity

Koenraad Van Doorslaer, Robert D. Burk

Research output: Book/ReportBook

23 Citations (Scopus)

Abstract

Members of the Alphapapillomavirus genus are the causative agent for virtually all cases of cervical cancer. However, strains (commonly referred to as types) within this genus span the entire range of pathogenicity from highly carcinogenic (e.g., HPV16, odds ratio = 281.9, responsible for 50% of all cervical cancers), moderately carcinogenic (e.g., HPV31) to not carcinogenic (e.g., HPV71). The persistent expression of the viral oncoproteins (E6 and E7) from HPV16 has been shown to be necessary and sufficient to transform primary human keratinocytes in vitro. A plethora of functions have been described for both oncoproteins, and through functional comparisons between HPV16 and HPV6, a subset of these functions have been suggested to be oncogenic. However, extrapolating functional differences from these comparisons is unlikely to tease apart the fine details. In this review, we argue that a thorough understanding of the molecular mechanisms differentiating oncogenic from nononcogenic types should be obtained by performing functional assays in an evolutionary and epidemiological framework. We continue by interpreting some recent results using this paradigm and end by suggesting directions for future inquiries.

Original languageEnglish (US)
PublisherUnknown Publisher
Number of pages22
Volume77
EditionC
DOIs
StatePublished - 2010

Publication series

NameAdvances in Virus Research
No.C
Volume77
ISSN (Print)00653527
ISSN (Electronic)15578399

Fingerprint

Oncogene Proteins
Alphapapillomavirus
Uterine Cervical Neoplasms
Keratinocytes
Virulence
Odds Ratio
In Vitro Techniques
Direction compound

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Medicine(all)

Cite this

Van Doorslaer, K., & Burk, R. D. (2010). Evolution of human papillomavirus carcinogenicity. (C ed.) (Advances in Virus Research; Vol. 77, No. C). Unknown Publisher. https://doi.org/10.1016/B978-0-12-385034-8.00002-8

Evolution of human papillomavirus carcinogenicity. / Van Doorslaer, Koenraad; Burk, Robert D.

C ed. Unknown Publisher, 2010. 22 p. (Advances in Virus Research; Vol. 77, No. C).

Research output: Book/ReportBook

Van Doorslaer, K & Burk, RD 2010, Evolution of human papillomavirus carcinogenicity. Advances in Virus Research, no. C, vol. 77, vol. 77, C edn, Unknown Publisher. https://doi.org/10.1016/B978-0-12-385034-8.00002-8
Van Doorslaer K, Burk RD. Evolution of human papillomavirus carcinogenicity. C ed. Unknown Publisher, 2010. 22 p. (Advances in Virus Research; C). https://doi.org/10.1016/B978-0-12-385034-8.00002-8
Van Doorslaer, Koenraad ; Burk, Robert D. / Evolution of human papillomavirus carcinogenicity. C ed. Unknown Publisher, 2010. 22 p. (Advances in Virus Research; C).
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