Evoked potentials in the assessment of neurotoxicity in humans

Joseph C. Arezzo, R. Simson, N. E. Brennan

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The present paper reviews strengths and weaknesses of evoked potentials (EPs) as an index of toxic insult to the nervous system. EPs are obtained by averaging successive samples of EEG time-locked to the presentation of stimuli. Components of the resulting waveform can be measured for amplitude, latency, and distribution. Normal ranges of these parameters have been characterized for auditory, visual and somatosensory stimuli. Auditory EPs have been studied in humans exposed to lead, trichloroethylene, and carbon monoxide. Changes in timing of short latency components and in amplitude of later cortical components have been reported. Methyl mercury, n-hexane and carbon monoxide cause complex changes in the waveshape of flash and patterned visual EPs. Similarly, specific components of somatosensory EPs are altered following exposure to carbon monoxide, lead and acrylamide. The current lack of standardized recording and analysis techniques has sometimes generated contradictory results, but the evidence thus far supports the ultimate usefulness of EPs as a neurotoxicological screening tool.

Original languageEnglish (US)
Pages (from-to)299-304
Number of pages6
JournalNeurobehavioral Toxicology and Teratology
Volume7
Issue number4
StatePublished - 1985

Fingerprint

Bioelectric potentials
Carbon Monoxide
Evoked Potentials
Trichloroethylene
Auditory Evoked Potentials
Somatosensory Evoked Potentials
Visual Evoked Potentials
Acrylamide
Poisons
Mercury
Nervous System
Electroencephalography
Reference Values
Neurology
Screening

ASJC Scopus subject areas

  • Embryology
  • Toxicology
  • Neuropsychology and Physiological Psychology

Cite this

Evoked potentials in the assessment of neurotoxicity in humans. / Arezzo, Joseph C.; Simson, R.; Brennan, N. E.

In: Neurobehavioral Toxicology and Teratology, Vol. 7, No. 4, 1985, p. 299-304.

Research output: Contribution to journalArticle

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