Evidence for the involvement of nigral GABAA receptors in seizures of adult rats

E. F. Sperber, J. N.D. Wurpel, D. Y. Zhao, S. L. Moshé

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Several studies have implicated the substantia nigra GABAergic system in the mediation of seizures in adult rats. The present study examines whether the different GABA receptors (GABAA and GABAB), are preferentially involved in this GABAergic seizure suppression mechanism. Adult rats were intranigrally infused with muscimol (GABAA receptor agonist), bicuculline (GABAA receptor antagonist) or baclofen (GABA1 receptor agonist) and were exposed to flurothyl seizures Results indicated that while infusions of muscimol had an anticonvulsant effect, infusions of bicuculline had a proconvulsant effect. Baclofen infusions were found to have no effect on seizures. These findings suggest an involvement of the nigral GABAA receptors in the mediation of seizures in adult rats.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalBrain Research
Volume480
Issue number1-2
DOIs
StatePublished - Feb 20 1989

Keywords

  • Baclofen
  • Bicuculline
  • Convulsion
  • Muscimol
  • Rat
  • Seizure
  • Substantia nigra
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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