Evidence for the involvement of nigral GABAA receptors in seizures of adult rats

E. F. Sperber, J. N D Wurpel, D. Y. Zhao, Solomon L. Moshe

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Several studies have implicated the substantia nigra GABAergic system in the mediation of seizures in adult rats. The present study examines whether the different GABA receptors (GABAA and GABAB), are preferentially involved in this GABAergic seizure suppression mechanism. Adult rats were intranigrally infused with muscimol (GABAA receptor agonist), bicuculline (GABAA receptor antagonist) or baclofen (GABA1 receptor agonist) and were exposed to flurothyl seizures Results indicated that while infusions of muscimol had an anticonvulsant effect, infusions of bicuculline had a proconvulsant effect. Baclofen infusions were found to have no effect on seizures. These findings suggest an involvement of the nigral GABAA receptors in the mediation of seizures in adult rats.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalBrain Research
Volume480
Issue number1-2
DOIs
StatePublished - Feb 20 1989

Fingerprint

Substantia Nigra
GABA-A Receptors
Seizures
Bicuculline
Flurothyl
GABA-B Receptors
GABA-A Receptor Agonists
GABA-A Receptor Antagonists
Muscimol
Baclofen
GABA Receptors
Anticonvulsants

Keywords

  • Baclofen
  • Bicuculline
  • Convulsion
  • Muscimol
  • Rat
  • Seizure
  • Substantia nigra
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Evidence for the involvement of nigral GABAA receptors in seizures of adult rats. / Sperber, E. F.; Wurpel, J. N D; Zhao, D. Y.; Moshe, Solomon L.

In: Brain Research, Vol. 480, No. 1-2, 20.02.1989, p. 378-382.

Research output: Contribution to journalArticle

Sperber, E. F. ; Wurpel, J. N D ; Zhao, D. Y. ; Moshe, Solomon L. / Evidence for the involvement of nigral GABAA receptors in seizures of adult rats. In: Brain Research. 1989 ; Vol. 480, No. 1-2. pp. 378-382.
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