Evidence for central regulation of glucose metabolism.

Michelle Carey, Sylvia Kehlenbrink, Meredith A. Hawkins

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Evidence for central regulation of glucose homeostasis is accumulating from both animal and human studies. Central nutrient and hormone sensing in the hypothalamus appears to coordinate regulation of whole body metabolism. Central signals activate ATP-sensitive potassium (KATP) channels, thereby down-regulating glucose production, likely through vagal efferent signals. Recent human studies are consistent with this hypothesis. The contributions of direct and central inputs to metabolic regulation are likely of comparable magnitude, with somewhat delayed central effects and more rapid peripheral effects. Understanding central regulation of glucose metabolism could promote the development of novel therapeutic approaches for such metabolic conditions as diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)34981-34988
Number of pages8
JournalThe Journal of biological chemistry
Volume288
Issue number49
StatePublished - Dec 6 2013
Externally publishedYes

Fingerprint

Metabolism
KATP Channels
Glucose
Medical problems
Nutrients
Hypothalamus
Diabetes Mellitus
Potassium
Animals
Homeostasis
Adenosine Triphosphate
Hormones
Food
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Evidence for central regulation of glucose metabolism. / Carey, Michelle; Kehlenbrink, Sylvia; Hawkins, Meredith A.

In: The Journal of biological chemistry, Vol. 288, No. 49, 06.12.2013, p. 34981-34988.

Research output: Contribution to journalArticle

Carey, M, Kehlenbrink, S & Hawkins, MA 2013, 'Evidence for central regulation of glucose metabolism.', The Journal of biological chemistry, vol. 288, no. 49, pp. 34981-34988.
Carey, Michelle ; Kehlenbrink, Sylvia ; Hawkins, Meredith A. / Evidence for central regulation of glucose metabolism. In: The Journal of biological chemistry. 2013 ; Vol. 288, No. 49. pp. 34981-34988.
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