Evidence for biliary excretion of vancomycin into stool during intravenous therapy: Potential implications for rectal colonization with vancomycin-resistant enterococci

Brian P. Currie, Luciano Lemos-Filho

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Sixty-three stool samples and five bile samples were prospectively collected from 33 patients receiving intravenous vancomycin therapy and were quantitatively analyzed for vancomycin by a competitive immuno-assay. Vancomycin was excreted via bile into the stools of almost all patients at concentrations of 3.3 to 94.8 μg/ml after ≥5 days of a therapy of 1 g every 12 h.

Original languageEnglish (US)
Pages (from-to)4427-4429
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume48
Issue number11
DOIs
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Evidence for biliary excretion of vancomycin into stool during intravenous therapy: Potential implications for rectal colonization with vancomycin-resistant enterococci'. Together they form a unique fingerprint.

  • Cite this