Evidence for biliary excretion of vancomycin into stool during intravenous therapy

Potential implications for rectal colonization with vancomycin-resistant enterococci

Brian P. Currie, Luciano Lemos-Filho

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Sixty-three stool samples and five bile samples were prospectively collected from 33 patients receiving intravenous vancomycin therapy and were quantitatively analyzed for vancomycin by a competitive immuno-assay. Vancomycin was excreted via bile into the stools of almost all patients at concentrations of 3.3 to 94.8 μg/ml after ≥5 days of a therapy of 1 g every 12 h.

Original languageEnglish (US)
Pages (from-to)4427-4429
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number11
DOIs
StatePublished - Nov 2004

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Vancomycin
Bile
Therapeutics
Hepatobiliary Elimination
Vancomycin-Resistant Enterococci

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Evidence for biliary excretion of vancomycin into stool during intravenous therapy : Potential implications for rectal colonization with vancomycin-resistant enterococci. / Currie, Brian P.; Lemos-Filho, Luciano.

In: Antimicrobial Agents and Chemotherapy, Vol. 48, No. 11, 11.2004, p. 4427-4429.

Research output: Contribution to journalArticle

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