Evidence-based guidelines for precision risk stratification- based screening (PRSBS) for colorectal cancer: Lessons learned from the us armed forces: Consensus and future directions

Itzhak Avital, Russell C. Langan, Thomas A. Summers, Scott R. Steele, Scott A. Waldman, Vadim Backman, Judy Yee, Aviram Nissan, Patrick Young, Craig Womeldorph, Paul Mancusco, Renee Mueller, Khristian Noto, Warren Grundfest, Anton J. Bilchik, Mladjan Protic, Martin Daumer, John Eberhardt, Yan Gao Man, Björn LDM BrücherAlexander Stojadinovic

Research output: Contribution to journalReview article

9 Scopus citations


Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States (U.S.), with estimates of 143,460 new cases and 51,690 deaths for the year 2012. Numerous organizations have published guidelines for CRC screening; however, these numerical estimates of incidence and disease-specific mortality have remained stable from years prior. Technological, genetic profiling, molecular and surgical advances in our modern era should allow us to improverisk stratification of patients with CRC and identify those who may benefit from preventive measures, early aggressive treatment, alternative treatment strategies, and/or frequent surveillance for the early detection of disease recurrence. To better negotiate future economic constraints and enhance patient outcomes, ultimately, we propose to apply the principals of personalized and precise cancer care to risk-stratify patients for CRC screening (Precision Risk Stratification- Based Screening, PRSBS). We believe that genetic, molecular, ethnic and socioeconomic disparities impact oncological outcomes in general, those related to CRC, in particular. This document highlights evidence-based screening recommendations and risk stratification methods in response to our CRC working group private-public consensus meeting held in March 2012. Our aim was to address how we could improve CRC risk stratification-based screening, and to provide a vision for the future to achieving superior survival rates for patients diagnosed with CRC.

Original languageEnglish (US)
Pages (from-to)172-192
Number of pages21
JournalJournal of Cancer
Issue number3
Publication statusPublished - Aug 30 2013



  • Cancer screening
  • Colon
  • Colorectal cancer
  • Consensus
  • Evidence-based medicine
  • Rectal
  • Risk identification

ASJC Scopus subject areas

  • Oncology

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