Everyday function profiles in prodromal stages of MCI: Prospective cohort study

Joe Verghese, Pierfilippo De Sanctis, Emmeline Ayers

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Introduction: The nature and course of limitations in everyday function in the early clinical stages of cognitive decline is not well known. Methods: We compared complex everyday functional profiles at baseline in 59 community-dwelling older individuals with normal cognitive performance who went on to develop incident mild cognitive impairment (MCI) (“pre-MCI”) with 284 older individuals who remained cognitively normal over follow-up. Results: The mean number of limitations on complex everyday function at baseline was 3.1 ± 3.0 in the 59 pre-MCI cases and 2.0 ± 2.4 in the 284 normal controls (P =.003). Pre-MCI cases had limitations in traveling, entertaining, remembering appointments, and hobbies compared to normal controls. A progressive increase in mild limitations on complex everyday function preceded the incidence of MCI (mean change: pre-MCI 1.9 ± 3.6 vs normal controls 0.5 ± 2.7, P <.001). Discussion: Prodromal stages of MCI are associated with progressive mild limitations in complex activities of daily living.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
StateAccepted/In press - 2022


  • MCI
  • assessment of dementia
  • cognitive aging
  • cohort studies

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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