Abstract
Introduction: The nature and course of limitations in everyday function in the early clinical stages of cognitive decline is not well known. Methods: We compared complex everyday functional profiles at baseline in 59 community-dwelling older individuals with normal cognitive performance who went on to develop incident mild cognitive impairment (MCI) (“pre-MCI”) with 284 older individuals who remained cognitively normal over follow-up. Results: The mean number of limitations on complex everyday function at baseline was 3.1 ± 3.0 in the 59 pre-MCI cases and 2.0 ± 2.4 in the 284 normal controls (P =.003). Pre-MCI cases had limitations in traveling, entertaining, remembering appointments, and hobbies compared to normal controls. A progressive increase in mild limitations on complex everyday function preceded the incidence of MCI (mean change: pre-MCI 1.9 ± 3.6 vs normal controls 0.5 ± 2.7, P <.001). Discussion: Prodromal stages of MCI are associated with progressive mild limitations in complex activities of daily living.
Original language | English (US) |
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Pages (from-to) | 498-506 |
Number of pages | 9 |
Journal | Alzheimer's and Dementia |
Volume | 19 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2023 |
Keywords
- MCI
- assessment of dementia
- cognitive aging
- cohort studies
ASJC Scopus subject areas
- Epidemiology
- Health Policy
- Developmental Neuroscience
- Clinical Neurology
- Geriatrics and Gerontology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health