TY - JOUR
T1 - Evaluation of esophageal cytology using a neural net-based interactive scanning system (the PAPNET system)
T2 - Its possible role in screening for esophageal and gastric carcinoma
AU - Koss, Leopold G.
AU - Morgenstern, Nora
AU - Tahir-Kheli, Naveed
AU - Suhrland, Mark
AU - Schreiber, Klaus
AU - Greenebaum, Ellen
PY - 1998/5
Y1 - 1998/5
N2 - A neural net-based, semiautomated, interactive computerized cell analysis system (The PAPNET system, Neuromedical Systems, Suffern, NY) was used to examine cells from 138 esophageal smears obtained by lavage, brushings, or balloon from as many patients. From each smear, trained human observers examined 128 cell images selected by the machine. Abnormal cells were identified in all 35 patients with cancer, whether esophageal, gastric, oral, or metastatic. Further, in 11 smears, the displayed images allowed the recognition of effects of radiotherapy and, in 14 smears, the diagnosis of a specific tumor type, such as squamous cell carcinoma (8 patients) or adenocarcinoma (6 patients). In 3 additional cases, the diagnosis of 'carcinoma, not further specified,' was established. One care of esophageal carcinoma in situ, not previously recognized on a smear or in the biopsy specimen, and one case of gastric adenocarcinoma, not recognized in the smear, were identified in PAPNET-generated images. The possible application of the apparatus to the triage of smears and population screening for esophageal and gastric carcinoma precursors is discussed.
AB - A neural net-based, semiautomated, interactive computerized cell analysis system (The PAPNET system, Neuromedical Systems, Suffern, NY) was used to examine cells from 138 esophageal smears obtained by lavage, brushings, or balloon from as many patients. From each smear, trained human observers examined 128 cell images selected by the machine. Abnormal cells were identified in all 35 patients with cancer, whether esophageal, gastric, oral, or metastatic. Further, in 11 smears, the displayed images allowed the recognition of effects of radiotherapy and, in 14 smears, the diagnosis of a specific tumor type, such as squamous cell carcinoma (8 patients) or adenocarcinoma (6 patients). In 3 additional cases, the diagnosis of 'carcinoma, not further specified,' was established. One care of esophageal carcinoma in situ, not previously recognized on a smear or in the biopsy specimen, and one case of gastric adenocarcinoma, not recognized in the smear, were identified in PAPNET-generated images. The possible application of the apparatus to the triage of smears and population screening for esophageal and gastric carcinoma precursors is discussed.
KW - Esophageal balloon sampling
KW - Esophageal brushing
KW - Esophageal carcinoma
KW - Esophageal washings
KW - Gastric carcinoma
KW - Neural net-based scanning system
KW - PAPNET
UR - http://www.scopus.com/inward/record.url?scp=0031945510&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031945510&partnerID=8YFLogxK
U2 - 10.1093/ajcp/109.5.549
DO - 10.1093/ajcp/109.5.549
M3 - Article
C2 - 9576572
AN - SCOPUS:0031945510
SN - 0002-9173
VL - 109
SP - 549
EP - 557
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 5
ER -
