Evaluation of 2-(3-aminobenzamido)-2-deoxy-D-glucose as a radiosensitizer

Sandra L. Winer, Robert Bases, Iraj Lalezari, Michael Brownlee, William A. Franklin

Research output: Contribution to journalArticle

Abstract

PURPOSE: 3-Aminobenzamide (3-AB), an inhibitor of poly(adenosine diphosphate [ADP]-ribose) synthetase, functions as a radiosensitizer in several human tumor cell lines. 2-(3-AB)-2-deoxy-D-glucose (3-AB-G) was designed to increase preferentially the intracellular concentration of the drug in tumor cells. Both the toxicity and effectiveness of 3-AB-G as a radiosensitizer were determined. MATERIALS AND METHODS: The toxicity of 3- AB-G was measured in HeLa and Chinese hamster ovary cells. The radiosensitizing effect of 3-AB-G was determined for both cell lines. RESULTS: 3-AB-G was not toxic to cells at concentrations of 10 mmol/L or less. 3-AB-G did not alter cell survival after irradiation. CONCLUSION: 3- AB-G was not an effective radiosensitizer for the cells tested. Coupling 2- deoxyglucose to 3-AB may block the uptake of the inhibitor into the cell by altering the ability of the receptor to recognize the molecule or may interfere with the specificity of the inhibitor for poly(ADP-ribose) synthetase.

Original languageEnglish (US)
Pages (from-to)267-269
Number of pages3
JournalRADIOLOGY
Volume196
Issue number1
DOIs
Publication statusPublished - Jul 1995

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Keywords

  • Radiobiology, cell and tissue studies
  • Therapeutic radiology, experimental

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Winer, S. L., Bases, R., Lalezari, I., Brownlee, M., & Franklin, W. A. (1995). Evaluation of 2-(3-aminobenzamido)-2-deoxy-D-glucose as a radiosensitizer. RADIOLOGY, 196(1), 267-269. https://doi.org/10.1148/radiology.196.1.7784578