TY - JOUR
T1 - Ets2 knockdown inhibits tumorigenesis in esophageal squamous cell carcinoma in vivo and in vitro
AU - Li, Qinghua
AU - Yang, Lu
AU - Han, Kang
AU - Zhu, Liqiang
AU - Zhang, Yanting
AU - Ma, Shanshan
AU - Zhang, Kun
AU - Yang, Bo
AU - Guan, Fangxia
PY - 2016
Y1 - 2016
N2 - Increased expression of Ets2 is reported upregulated in esophageal squamous cell carcinoma tissue. However, the function of Ets2 in carcinogenesis of ESCC is poorly understood. Here, the rise of Ets2 was confirmed in ESCC cells and Ets2 depletion by RNA interference promotes cell apoptosis, inhibits cell proliferation, attenuates cell invasion and induces cell cycle G0/G1 arrest in vitro. Moreover, in vivo, Xenograft mouse model studies showed Ets2 knockdown inhibits tumor formation and metastasis significantly. Furthermore, Ets2 depletion inactivates the mTOR/p70S6K signaling pathway both in vitro and in vivo. Taken together, these findings strongly suggest that a critical role of Ets2 in human ESCC pathogenesis via the inactivation of the mTOR/p70S6K signaling pathway.
AB - Increased expression of Ets2 is reported upregulated in esophageal squamous cell carcinoma tissue. However, the function of Ets2 in carcinogenesis of ESCC is poorly understood. Here, the rise of Ets2 was confirmed in ESCC cells and Ets2 depletion by RNA interference promotes cell apoptosis, inhibits cell proliferation, attenuates cell invasion and induces cell cycle G0/G1 arrest in vitro. Moreover, in vivo, Xenograft mouse model studies showed Ets2 knockdown inhibits tumor formation and metastasis significantly. Furthermore, Ets2 depletion inactivates the mTOR/p70S6K signaling pathway both in vitro and in vivo. Taken together, these findings strongly suggest that a critical role of Ets2 in human ESCC pathogenesis via the inactivation of the mTOR/p70S6K signaling pathway.
KW - Apoptosis
KW - Esophageal squamous cell carcinoma
KW - Ets2
KW - MTOR/p70S6K signaling pathway
KW - Proliferation
UR - http://www.scopus.com/inward/record.url?scp=84992491314&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992491314&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.11369
DO - 10.18632/oncotarget.11369
M3 - Article
C2 - 27556183
AN - SCOPUS:84992491314
SN - 1949-2553
VL - 7
SP - 61458
EP - 61468
JO - Oncotarget
JF - Oncotarget
IS - 38
ER -