Ets2 knockdown inhibits tumorigenesis in esophageal squamous cell carcinoma in vivo and in vitro

Qinghua Li, Lu Yang, Kang Han, Liqiang Zhu, Yanting Zhang, Shanshan Ma, Kun Zhang, Bo Yang, Fangxia Guan

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Increased expression of Ets2 is reported upregulated in esophageal squamous cell carcinoma tissue. However, the function of Ets2 in carcinogenesis of ESCC is poorly understood. Here, the rise of Ets2 was confirmed in ESCC cells and Ets2 depletion by RNA interference promotes cell apoptosis, inhibits cell proliferation, attenuates cell invasion and induces cell cycle G0/G1 arrest in vitro. Moreover, in vivo, Xenograft mouse model studies showed Ets2 knockdown inhibits tumor formation and metastasis significantly. Furthermore, Ets2 depletion inactivates the mTOR/p70S6K signaling pathway both in vitro and in vivo. Taken together, these findings strongly suggest that a critical role of Ets2 in human ESCC pathogenesis via the inactivation of the mTOR/p70S6K signaling pathway.

Original languageEnglish (US)
Pages (from-to)61458-61468
Number of pages11
JournalOncotarget
Volume7
Issue number38
DOIs
StatePublished - Jan 1 2016

Keywords

  • Apoptosis
  • Esophageal squamous cell carcinoma
  • Ets2
  • MTOR/p70S6K signaling pathway
  • Proliferation

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Li, Q., Yang, L., Han, K., Zhu, L., Zhang, Y., Ma, S., Zhang, K., Yang, B., & Guan, F. (2016). Ets2 knockdown inhibits tumorigenesis in esophageal squamous cell carcinoma in vivo and in vitro. Oncotarget, 7(38), 61458-61468. https://doi.org/10.18632/oncotarget.11369