Ethnic and gender differences in cough reflex sensitivity

Peter Vytautas Dicpinigaitis, Valerie R C Allusson, Annmarie Baldanti, Jhansi R. Nalamati

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Although recent studies have suggested that the cough reflex is more sensitive in women than in men, ethnic differences in cough reflex sensitivity have not previously been investigated. Objectives: To evaluate ethnic and gender differences in cough reflex sensitivity. Methods: We performed capsaicin cough challenge testing in 182 healthy volunteers of three distinct ethnic groups: Caucasian (white, non-Hispanic, of European origin), Indian (originating from the Indian subcontinent) and Chinese. The concentration of capsaicin inducing 2 or more (C2) and 5 or more coughs (C5) was determined in each subject. Results: Mean (±SEM) values for log C5 demonstrated that, within each ethnic group, the cough reflex was more sensitive in women: p =0.00002 for Caucasian subjects; p =0.003 for Indian volunteers; and p =0.002 for Chinese subjects. Examination of C2 data yielded similar results. When subjects were evaluated by gender, multivariate analysis of variance demonstrated no ethnic differences in sensitivity to capsaicin. Conclusion: Our data do not support the presence of significant ethnic differences in cough reflex sensitivity, but do confirm previous data demonstrating lower cough thresholds in women. Copyright

Original languageEnglish (US)
Pages (from-to)480-482
Number of pages3
JournalRespiration
Volume68
Issue number5
DOIs
StatePublished - 2001

Fingerprint

Cough
Reflex
Capsaicin
Ethnic Groups
Volunteers
Analysis of Variance
Healthy Volunteers
Multivariate Analysis

Keywords

  • Capsaicin
  • Cough
  • Ethnicity
  • Gender

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Dicpinigaitis, P. V., Allusson, V. R. C., Baldanti, A., & Nalamati, J. R. (2001). Ethnic and gender differences in cough reflex sensitivity. Respiration, 68(5), 480-482. https://doi.org/10.1159/000050554

Ethnic and gender differences in cough reflex sensitivity. / Dicpinigaitis, Peter Vytautas; Allusson, Valerie R C; Baldanti, Annmarie; Nalamati, Jhansi R.

In: Respiration, Vol. 68, No. 5, 2001, p. 480-482.

Research output: Contribution to journalArticle

Dicpinigaitis, PV, Allusson, VRC, Baldanti, A & Nalamati, JR 2001, 'Ethnic and gender differences in cough reflex sensitivity', Respiration, vol. 68, no. 5, pp. 480-482. https://doi.org/10.1159/000050554
Dicpinigaitis, Peter Vytautas ; Allusson, Valerie R C ; Baldanti, Annmarie ; Nalamati, Jhansi R. / Ethnic and gender differences in cough reflex sensitivity. In: Respiration. 2001 ; Vol. 68, No. 5. pp. 480-482.
@article{ee02fa050ab84544ab39320886c3aa90,
title = "Ethnic and gender differences in cough reflex sensitivity",
abstract = "Background: Although recent studies have suggested that the cough reflex is more sensitive in women than in men, ethnic differences in cough reflex sensitivity have not previously been investigated. Objectives: To evaluate ethnic and gender differences in cough reflex sensitivity. Methods: We performed capsaicin cough challenge testing in 182 healthy volunteers of three distinct ethnic groups: Caucasian (white, non-Hispanic, of European origin), Indian (originating from the Indian subcontinent) and Chinese. The concentration of capsaicin inducing 2 or more (C2) and 5 or more coughs (C5) was determined in each subject. Results: Mean (±SEM) values for log C5 demonstrated that, within each ethnic group, the cough reflex was more sensitive in women: p =0.00002 for Caucasian subjects; p =0.003 for Indian volunteers; and p =0.002 for Chinese subjects. Examination of C2 data yielded similar results. When subjects were evaluated by gender, multivariate analysis of variance demonstrated no ethnic differences in sensitivity to capsaicin. Conclusion: Our data do not support the presence of significant ethnic differences in cough reflex sensitivity, but do confirm previous data demonstrating lower cough thresholds in women. Copyright",
keywords = "Capsaicin, Cough, Ethnicity, Gender",
author = "Dicpinigaitis, {Peter Vytautas} and Allusson, {Valerie R C} and Annmarie Baldanti and Nalamati, {Jhansi R.}",
year = "2001",
doi = "10.1159/000050554",
language = "English (US)",
volume = "68",
pages = "480--482",
journal = "Respiration; international review of thoracic diseases",
issn = "0025-7931",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Ethnic and gender differences in cough reflex sensitivity

AU - Dicpinigaitis, Peter Vytautas

AU - Allusson, Valerie R C

AU - Baldanti, Annmarie

AU - Nalamati, Jhansi R.

PY - 2001

Y1 - 2001

N2 - Background: Although recent studies have suggested that the cough reflex is more sensitive in women than in men, ethnic differences in cough reflex sensitivity have not previously been investigated. Objectives: To evaluate ethnic and gender differences in cough reflex sensitivity. Methods: We performed capsaicin cough challenge testing in 182 healthy volunteers of three distinct ethnic groups: Caucasian (white, non-Hispanic, of European origin), Indian (originating from the Indian subcontinent) and Chinese. The concentration of capsaicin inducing 2 or more (C2) and 5 or more coughs (C5) was determined in each subject. Results: Mean (±SEM) values for log C5 demonstrated that, within each ethnic group, the cough reflex was more sensitive in women: p =0.00002 for Caucasian subjects; p =0.003 for Indian volunteers; and p =0.002 for Chinese subjects. Examination of C2 data yielded similar results. When subjects were evaluated by gender, multivariate analysis of variance demonstrated no ethnic differences in sensitivity to capsaicin. Conclusion: Our data do not support the presence of significant ethnic differences in cough reflex sensitivity, but do confirm previous data demonstrating lower cough thresholds in women. Copyright

AB - Background: Although recent studies have suggested that the cough reflex is more sensitive in women than in men, ethnic differences in cough reflex sensitivity have not previously been investigated. Objectives: To evaluate ethnic and gender differences in cough reflex sensitivity. Methods: We performed capsaicin cough challenge testing in 182 healthy volunteers of three distinct ethnic groups: Caucasian (white, non-Hispanic, of European origin), Indian (originating from the Indian subcontinent) and Chinese. The concentration of capsaicin inducing 2 or more (C2) and 5 or more coughs (C5) was determined in each subject. Results: Mean (±SEM) values for log C5 demonstrated that, within each ethnic group, the cough reflex was more sensitive in women: p =0.00002 for Caucasian subjects; p =0.003 for Indian volunteers; and p =0.002 for Chinese subjects. Examination of C2 data yielded similar results. When subjects were evaluated by gender, multivariate analysis of variance demonstrated no ethnic differences in sensitivity to capsaicin. Conclusion: Our data do not support the presence of significant ethnic differences in cough reflex sensitivity, but do confirm previous data demonstrating lower cough thresholds in women. Copyright

KW - Capsaicin

KW - Cough

KW - Ethnicity

KW - Gender

UR - http://www.scopus.com/inward/record.url?scp=0034756225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034756225&partnerID=8YFLogxK

U2 - 10.1159/000050554

DO - 10.1159/000050554

M3 - Article

C2 - 11694809

AN - SCOPUS:0034756225

VL - 68

SP - 480

EP - 482

JO - Respiration; international review of thoracic diseases

JF - Respiration; international review of thoracic diseases

SN - 0025-7931

IS - 5

ER -