Ethanol-Taurine Interactions in the Brain: Mechanisms and Pathophysiological Implications

Jan Albrecht, Magdalena Zielinska, J. W. Allen, Offie P. Soldin, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter discusses the interactions of ethanol and taurine in the brain and the mechanisms and pathophysiology. Taurine is a nonproteinaceous sulfur amino acid present at high concentrations both in neurons and astrocytes in different brain regions. Taurine is a γ-aminobutyric acidA (GABAA) and glycine receptor agonist in distinct regions of cerebral cortex, cerebellum, and hypothalamus. Taurine is also readily released from and taken up by astrocytes and neurons: its intercellular redistribution upon hyper- or hyposomotic challenge suggests that taurine partici- pates in cell volume regulation. In the neuro-endocrine structures of the hypothalamus, taurine released from astrocytes in response to hypotonic stimulus acts on glycine receptors in the adjacent neurons, contributing to hypotonic inhibition of neurosecretion of oxytocin and vasopressin. Exogenously added taurine is neuroprotective by an anti-excitotoxic mechanism, involving direct interaction with GABAA and/or ionotropic glutamate receptors, mostly of the N-methyl D-aspartate type. A plethora of stimuli trigger taurine release from astrocytes or neurons by mechanisms bypassing changes in the intracellular osmotic pressure, thus increasing the extracellular concentration of taurine and facilitating its neuromodulatory function. Ethanol and taurine share molecular targets in the brain.

Original languageEnglish (US)
Title of host publicationComprehensive Handbook of Alcohol Related Pathology
PublisherElsevier Inc.
Pages845-854
Number of pages10
Volume2-3
ISBN (Print)9780080502311, 9780125643702
DOIs
StatePublished - Dec 30 2004
Externally publishedYes

Fingerprint

Taurine
Brain
Ethanol
Astrocytes
Neurons
Glycine Receptors
Hypothalamus
Neurosecretion
GABA-A Receptor Agonists
Sulfur Amino Acids
Ionotropic Glutamate Receptors
Osmotic Pressure
Oxytocin
N-Methylaspartate
GABA-A Receptors
Vasopressins
Cell Size
Cerebral Cortex
Cerebellum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Albrecht, J., Zielinska, M., Allen, J. W., Soldin, O. P., & Aschner, M. (2004). Ethanol-Taurine Interactions in the Brain: Mechanisms and Pathophysiological Implications. In Comprehensive Handbook of Alcohol Related Pathology (Vol. 2-3, pp. 845-854). Elsevier Inc.. https://doi.org/10.1016/B978-012564370-2/50068-4

Ethanol-Taurine Interactions in the Brain : Mechanisms and Pathophysiological Implications. / Albrecht, Jan; Zielinska, Magdalena; Allen, J. W.; Soldin, Offie P.; Aschner, Michael.

Comprehensive Handbook of Alcohol Related Pathology. Vol. 2-3 Elsevier Inc., 2004. p. 845-854.

Research output: Chapter in Book/Report/Conference proceedingChapter

Albrecht, J, Zielinska, M, Allen, JW, Soldin, OP & Aschner, M 2004, Ethanol-Taurine Interactions in the Brain: Mechanisms and Pathophysiological Implications. in Comprehensive Handbook of Alcohol Related Pathology. vol. 2-3, Elsevier Inc., pp. 845-854. https://doi.org/10.1016/B978-012564370-2/50068-4
Albrecht J, Zielinska M, Allen JW, Soldin OP, Aschner M. Ethanol-Taurine Interactions in the Brain: Mechanisms and Pathophysiological Implications. In Comprehensive Handbook of Alcohol Related Pathology. Vol. 2-3. Elsevier Inc. 2004. p. 845-854 https://doi.org/10.1016/B978-012564370-2/50068-4
Albrecht, Jan ; Zielinska, Magdalena ; Allen, J. W. ; Soldin, Offie P. ; Aschner, Michael. / Ethanol-Taurine Interactions in the Brain : Mechanisms and Pathophysiological Implications. Comprehensive Handbook of Alcohol Related Pathology. Vol. 2-3 Elsevier Inc., 2004. pp. 845-854
@inbook{94698840e9d4418da5957483ad9dedd5,
title = "Ethanol-Taurine Interactions in the Brain: Mechanisms and Pathophysiological Implications",
abstract = "This chapter discusses the interactions of ethanol and taurine in the brain and the mechanisms and pathophysiology. Taurine is a nonproteinaceous sulfur amino acid present at high concentrations both in neurons and astrocytes in different brain regions. Taurine is a γ-aminobutyric acidA (GABAA) and glycine receptor agonist in distinct regions of cerebral cortex, cerebellum, and hypothalamus. Taurine is also readily released from and taken up by astrocytes and neurons: its intercellular redistribution upon hyper- or hyposomotic challenge suggests that taurine partici- pates in cell volume regulation. In the neuro-endocrine structures of the hypothalamus, taurine released from astrocytes in response to hypotonic stimulus acts on glycine receptors in the adjacent neurons, contributing to hypotonic inhibition of neurosecretion of oxytocin and vasopressin. Exogenously added taurine is neuroprotective by an anti-excitotoxic mechanism, involving direct interaction with GABAA and/or ionotropic glutamate receptors, mostly of the N-methyl D-aspartate type. A plethora of stimuli trigger taurine release from astrocytes or neurons by mechanisms bypassing changes in the intracellular osmotic pressure, thus increasing the extracellular concentration of taurine and facilitating its neuromodulatory function. Ethanol and taurine share molecular targets in the brain.",
author = "Jan Albrecht and Magdalena Zielinska and Allen, {J. W.} and Soldin, {Offie P.} and Michael Aschner",
year = "2004",
month = "12",
day = "30",
doi = "10.1016/B978-012564370-2/50068-4",
language = "English (US)",
isbn = "9780080502311",
volume = "2-3",
pages = "845--854",
booktitle = "Comprehensive Handbook of Alcohol Related Pathology",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Ethanol-Taurine Interactions in the Brain

T2 - Mechanisms and Pathophysiological Implications

AU - Albrecht, Jan

AU - Zielinska, Magdalena

AU - Allen, J. W.

AU - Soldin, Offie P.

AU - Aschner, Michael

PY - 2004/12/30

Y1 - 2004/12/30

N2 - This chapter discusses the interactions of ethanol and taurine in the brain and the mechanisms and pathophysiology. Taurine is a nonproteinaceous sulfur amino acid present at high concentrations both in neurons and astrocytes in different brain regions. Taurine is a γ-aminobutyric acidA (GABAA) and glycine receptor agonist in distinct regions of cerebral cortex, cerebellum, and hypothalamus. Taurine is also readily released from and taken up by astrocytes and neurons: its intercellular redistribution upon hyper- or hyposomotic challenge suggests that taurine partici- pates in cell volume regulation. In the neuro-endocrine structures of the hypothalamus, taurine released from astrocytes in response to hypotonic stimulus acts on glycine receptors in the adjacent neurons, contributing to hypotonic inhibition of neurosecretion of oxytocin and vasopressin. Exogenously added taurine is neuroprotective by an anti-excitotoxic mechanism, involving direct interaction with GABAA and/or ionotropic glutamate receptors, mostly of the N-methyl D-aspartate type. A plethora of stimuli trigger taurine release from astrocytes or neurons by mechanisms bypassing changes in the intracellular osmotic pressure, thus increasing the extracellular concentration of taurine and facilitating its neuromodulatory function. Ethanol and taurine share molecular targets in the brain.

AB - This chapter discusses the interactions of ethanol and taurine in the brain and the mechanisms and pathophysiology. Taurine is a nonproteinaceous sulfur amino acid present at high concentrations both in neurons and astrocytes in different brain regions. Taurine is a γ-aminobutyric acidA (GABAA) and glycine receptor agonist in distinct regions of cerebral cortex, cerebellum, and hypothalamus. Taurine is also readily released from and taken up by astrocytes and neurons: its intercellular redistribution upon hyper- or hyposomotic challenge suggests that taurine partici- pates in cell volume regulation. In the neuro-endocrine structures of the hypothalamus, taurine released from astrocytes in response to hypotonic stimulus acts on glycine receptors in the adjacent neurons, contributing to hypotonic inhibition of neurosecretion of oxytocin and vasopressin. Exogenously added taurine is neuroprotective by an anti-excitotoxic mechanism, involving direct interaction with GABAA and/or ionotropic glutamate receptors, mostly of the N-methyl D-aspartate type. A plethora of stimuli trigger taurine release from astrocytes or neurons by mechanisms bypassing changes in the intracellular osmotic pressure, thus increasing the extracellular concentration of taurine and facilitating its neuromodulatory function. Ethanol and taurine share molecular targets in the brain.

UR - http://www.scopus.com/inward/record.url?scp=84943253187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943253187&partnerID=8YFLogxK

U2 - 10.1016/B978-012564370-2/50068-4

DO - 10.1016/B978-012564370-2/50068-4

M3 - Chapter

AN - SCOPUS:84943253187

SN - 9780080502311

SN - 9780125643702

VL - 2-3

SP - 845

EP - 854

BT - Comprehensive Handbook of Alcohol Related Pathology

PB - Elsevier Inc.

ER -