Estimating recombination rates from genetic variation in humans

Adam Auton, Gil McVean

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

Recombination acts to shuffle the existing genetic variation within a population, leading to various approaches for detecting its action and estimating the rate at which it occurs. Here, we discuss the principal methodological and analytical approaches taken to understanding the distribution of recombination across the human genome. We first discuss the detection of recent crossover events in both well-characterised pedigrees and larger populations with extensive recent shared ancestry. We then describe approaches for learning about the fine-scale structure of recombination rate variation from patterns of genetic variation in unrelated individuals. Finally, we show how related approaches using individuals of admixed ancestry can provide an alternative approach to analysing recombination. Approaches differ not only in the statistical methods used, but also in the resolution of inference, the timescale over which recombination events are detected, and the extent to which inter-individual variation can be identified.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages217-237
Number of pages21
Volume856
DOIs
StatePublished - 2012
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume856
ISSN (Print)10643745

Fingerprint

Genetic Recombination
Human Genome
Pedigree
Population
Learning

Keywords

  • Admixture
  • Linkage disequilibrium
  • Pedigree analysis
  • Recombination

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Auton, A., & McVean, G. (2012). Estimating recombination rates from genetic variation in humans. In Methods in Molecular Biology (Vol. 856, pp. 217-237). (Methods in Molecular Biology; Vol. 856). https://doi.org/10.1007/978-1-61779-585-5_9

Estimating recombination rates from genetic variation in humans. / Auton, Adam; McVean, Gil.

Methods in Molecular Biology. Vol. 856 2012. p. 217-237 (Methods in Molecular Biology; Vol. 856).

Research output: Chapter in Book/Report/Conference proceedingChapter

Auton, A & McVean, G 2012, Estimating recombination rates from genetic variation in humans. in Methods in Molecular Biology. vol. 856, Methods in Molecular Biology, vol. 856, pp. 217-237. https://doi.org/10.1007/978-1-61779-585-5_9
Auton A, McVean G. Estimating recombination rates from genetic variation in humans. In Methods in Molecular Biology. Vol. 856. 2012. p. 217-237. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-61779-585-5_9
Auton, Adam ; McVean, Gil. / Estimating recombination rates from genetic variation in humans. Methods in Molecular Biology. Vol. 856 2012. pp. 217-237 (Methods in Molecular Biology).
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