Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging

Gaetano Santulli, Andrew R. Marks

Research output: Contribution to journalArticle

97 Scopus citations


Calcium (Ca2+) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca2+ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca2+ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.

Original languageEnglish (US)
Pages (from-to)206-222
Number of pages17
JournalCurrent Molecular Pharmacology
Issue number2
StatePublished - Oct 1 2015
Externally publishedYes



  • Aging
  • Arrhythmias
  • Cognitive dysfunction
  • Diabetes
  • Excitation-contraction coupling
  • Heart failure
  • IP3 receptors
  • Metabolism
  • Mitochondria
  • Neurodegenerative disorders
  • RyR
  • Skeletal muscle

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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