Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging

Gaetano Santulli; Andrew R. Marks

doi:10.2174/1874467208666150507105105

Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging

Gaetano Santulli, Andrew R. Marks

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Abstract

Calcium (Ca²⁺) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca²⁺ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca²⁺ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.

Original language	English (US)
Pages (from-to)	206-222
Number of pages	17
Journal	Current Molecular Pharmacology
Volume	8
Issue number	2
DOIs	https://doi.org/10.2174/1874467208666150507105105
State	Published - Oct 1 2015
Externally published	Yes

Keywords

Aging
Arrhythmias
Cognitive dysfunction
Diabetes
Excitation-contraction coupling
Heart failure
IP3 receptors
Metabolism
Mitochondria
Neurodegenerative disorders
RyR
Skeletal muscle

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/1874467208666150507105105

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title = "Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging",

abstract = "Calcium (Ca2+) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca2+ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca2+ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.",

keywords = "Aging, Arrhythmias, Cognitive dysfunction, Diabetes, Excitation-contraction coupling, Heart failure, IP3 receptors, Metabolism, Mitochondria, Neurodegenerative disorders, RyR, Skeletal muscle",

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AU - Marks, Andrew R.

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N2 - Calcium (Ca2+) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca2+ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca2+ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.

AB - Calcium (Ca2+) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca2+ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca2+ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.

KW - Aging

KW - Arrhythmias

KW - Cognitive dysfunction

KW - Diabetes

KW - Excitation-contraction coupling

KW - Heart failure

KW - IP3 receptors

KW - Metabolism

KW - Mitochondria

KW - Neurodegenerative disorders

KW - RyR

KW - Skeletal muscle

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Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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