Abstract
Introduction: Eribulin is a non-taxane, macrocyclic, synthetic, ketone analog of halichondrin B with a microtubule inhibitory action specific toward plus ends. It is approved by United States Food and Drug Administration (USFDA) for the treatment of patients with unresectable or metastatic liposarcoma who have received a prior anthracycline-containing regimen. It is also approved as a third line therapy for patients with metastatic breast cancer who have received a prior treatment with anthracycline and taxane in either adjuvant or metastatic setting. It has also undergone investigation in various cancers including non-small cell lung cancer (NSCLC). Areas covered: This review covers eribulin in detail with regards to pharmacodynamics, mechanism of action, pharmacokinetics, published phase I studies along with special focus on phase II and III studies of eribulin in NSCLC. Expert opinion: Eribulin is a potent chemotherapeutic agent with acceptable and easily manageable toxicity profile. It has shown activity in NSCLC. However, the management of NSCLC is undergoing rapid evolution with introduction of newer immune mediated and targeted agents. The way to move forward is to combine eribulin with novel immune checkpoint inhibitors, targeted agents and chemotherapies in appropriate line of therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 495-508 |
| Number of pages | 14 |
| Journal | Expert Opinion on Investigational Drugs |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 3 2017 |
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Keywords
- E7389
- Eribulin
- Halaven
- microtubule inhibitor
- NSCLC
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
Cite this
Eribulin in non-small cell lung cancer : challenges and potential strategies. / Swami, Umang; Shah, Umang; Goel, Sanjay.
In: Expert Opinion on Investigational Drugs, Vol. 26, No. 4, 03.04.2017, p. 495-508.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Eribulin in non-small cell lung cancer
T2 - challenges and potential strategies
AU - Swami, Umang
AU - Shah, Umang
AU - Goel, Sanjay
PY - 2017/4/3
Y1 - 2017/4/3
N2 - Introduction: Eribulin is a non-taxane, macrocyclic, synthetic, ketone analog of halichondrin B with a microtubule inhibitory action specific toward plus ends. It is approved by United States Food and Drug Administration (USFDA) for the treatment of patients with unresectable or metastatic liposarcoma who have received a prior anthracycline-containing regimen. It is also approved as a third line therapy for patients with metastatic breast cancer who have received a prior treatment with anthracycline and taxane in either adjuvant or metastatic setting. It has also undergone investigation in various cancers including non-small cell lung cancer (NSCLC). Areas covered: This review covers eribulin in detail with regards to pharmacodynamics, mechanism of action, pharmacokinetics, published phase I studies along with special focus on phase II and III studies of eribulin in NSCLC. Expert opinion: Eribulin is a potent chemotherapeutic agent with acceptable and easily manageable toxicity profile. It has shown activity in NSCLC. However, the management of NSCLC is undergoing rapid evolution with introduction of newer immune mediated and targeted agents. The way to move forward is to combine eribulin with novel immune checkpoint inhibitors, targeted agents and chemotherapies in appropriate line of therapy.
AB - Introduction: Eribulin is a non-taxane, macrocyclic, synthetic, ketone analog of halichondrin B with a microtubule inhibitory action specific toward plus ends. It is approved by United States Food and Drug Administration (USFDA) for the treatment of patients with unresectable or metastatic liposarcoma who have received a prior anthracycline-containing regimen. It is also approved as a third line therapy for patients with metastatic breast cancer who have received a prior treatment with anthracycline and taxane in either adjuvant or metastatic setting. It has also undergone investigation in various cancers including non-small cell lung cancer (NSCLC). Areas covered: This review covers eribulin in detail with regards to pharmacodynamics, mechanism of action, pharmacokinetics, published phase I studies along with special focus on phase II and III studies of eribulin in NSCLC. Expert opinion: Eribulin is a potent chemotherapeutic agent with acceptable and easily manageable toxicity profile. It has shown activity in NSCLC. However, the management of NSCLC is undergoing rapid evolution with introduction of newer immune mediated and targeted agents. The way to move forward is to combine eribulin with novel immune checkpoint inhibitors, targeted agents and chemotherapies in appropriate line of therapy.
KW - E7389
KW - Eribulin
KW - Halaven
KW - microtubule inhibitor
KW - NSCLC
UR - http://www.scopus.com/inward/record.url?scp=85013436967&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85013436967&partnerID=8YFLogxK
U2 - 10.1080/13543784.2017.1292250
DO - 10.1080/13543784.2017.1292250
M3 - Article
VL - 26
SP - 495
EP - 508
JO - Current Opinion in Investigational Drugs
JF - Current Opinion in Investigational Drugs
SN - 1354-3784
IS - 4
ER -