Epileptogenesis in neonatal brain

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Epilepsy is a chronic neurological disorder affecting 65 million people worldwide. The etiologies of seizures can often be identified as genetic, metabolic, structural, immunologic or infectious, but in many cases the cause is unknown with the current diagnostic tools. Epileptogenesis is a process during which genetic or other acquired etiologies/insults lead to functional, structural, or network reorganization changes in the brain that may lead to the development of, or progression of, spontaneous seizures. During development, there are continuous changes in the structure, function, and network operation that also show sex specificity, which may alter the mechanisms underlying the generation of seizures (ictogenesis) and epileptogenesis. Understanding the mechanisms of early life epileptogenesis will enable the development of rationally designed age- and sex-appropriate therapies that would improve the overall quality of patients' lives. Here, we discuss some of these processes that may affect seizure generation and epileptogenesis in the neonatal brain.

Original languageEnglish (US)
JournalSeminars in Fetal and Neonatal Medicine
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Seizures
Brain
Nervous System Diseases
Epilepsy
Therapeutics

Keywords

  • Epilepsy
  • Genetic
  • Kindling
  • Rodent
  • Seizure
  • Status epilepticus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Epileptogenesis in neonatal brain. / Katsarou, Anna Maria; Galanopoulou, Aristea S.; Moshe, Solomon L.

In: Seminars in Fetal and Neonatal Medicine, 01.01.2018.

Research output: Contribution to journalArticle

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