Epileptogenesis and rational therapeutic strategies

H. Stefan; F. H. Lopes Da Silva; W. Löscher; D. Schmidt; E. Perucca; M. J. Brodie; P. A.J.M. Boon; W. H. Theodore; S. L. Moshé

doi:10.1111/j.1600-0404.2005.00561.x

Epileptogenesis and rational therapeutic strategies

H. Stefan, F. H. Lopes Da Silva, W. Löscher, D. Schmidt, E. Perucca, M. J. Brodie, P. A.J.M. Boon, W. H. Theodore, S. L. Moshé

Neurology

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

The understanding of neurobiological mechanisms of epileptogenesis is essential for rational approaches for a possible disease modification as well as treatment of underlying causes of the epilepsies. More effort is necessary to translate results from basic investigations into new approaches for clinical research and to better understand a relationship with findings from clinical studies. The following report is a condensed synapsis in which molecular mechanisms of epileptogenesis, pharmacological modulation of epileptogenesis, evidence based therapy, refractoriness and prediction of outcome is provided in order to stimulate further collaborative international research.

Original language	English (US)
Pages (from-to)	139-155
Number of pages	17
Journal	Acta Neurologica Scandinavica
Volume	113
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0404.2005.00561.x
State	Published - Mar 2006

Keywords

Epileptogenesis
Evidence
Molecular biology
Neurobiological mechanisms
Rational treatment

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1600-0404.2005.00561.x

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AU - Stefan, H.

AU - Lopes Da Silva, F. H.

AU - Löscher, W.

AU - Schmidt, D.

AU - Perucca, E.

AU - Brodie, M. J.

AU - Boon, P. A.J.M.

AU - Theodore, W. H.

AU - Moshé, S. L.

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AB - The understanding of neurobiological mechanisms of epileptogenesis is essential for rational approaches for a possible disease modification as well as treatment of underlying causes of the epilepsies. More effort is necessary to translate results from basic investigations into new approaches for clinical research and to better understand a relationship with findings from clinical studies. The following report is a condensed synapsis in which molecular mechanisms of epileptogenesis, pharmacological modulation of epileptogenesis, evidence based therapy, refractoriness and prediction of outcome is provided in order to stimulate further collaborative international research.

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KW - Evidence

KW - Molecular biology

KW - Neurobiological mechanisms

KW - Rational treatment

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Epileptogenesis and rational therapeutic strategies

Abstract

Keywords

ASJC Scopus subject areas

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