Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States

Urvi A. Shah, Nishi Shah, Baozhen Qiao, Ana Acuna-Villaorduna, Kith Pradhan, Diego Adrianzen Herrera, R. Alejandro Sica, Aditi Shastri, Ioannis Mantzaris, Olga Derman, Noah Kornblum, Ira Braunschweig, B. Hilda Ye, Amit Verma, Murali Janakiram

Research output: Contribution to journalArticle

Abstract

Background: Globally, 5 million to 10 million people are infected with human T-cell leukemia virus type 1, which causes adult T-cell leukemia/lymphoma (ATLL) in 2% to 5% of the carriers. ATLL is a rare but extremely aggressive malignancy that can be challenging to diagnose. Very little data exist on the incidence patterns of ATLL in the United States. Methods: ATLL cases reported to the National Program of Cancer Registries, the Surveillance, Epidemiology, and End Results (SEER) program, and the New York State Cancer Registry were used for the study. Age-adjusted incidence rates were calculated by age, race/ethnicity, sex, and year of diagnosis. The 5-year survival rate was compared among race/ethnicity groups with the SEER data. Results: During 2001-2015, 2148 ATLL cases were diagnosed in the United States, 18% of which were in New York State. New York State had the highest incidence rate for ATLL, with a rising trend especially among non-Hispanic blacks (NHBs), whereas the incidence was stable across the remainder of the United States. NHBs were diagnosed at a younger median age (54 years) and had a shorter overall survival (6 months). In New York City, only 22.6% of the ATLL cases diagnosed were born in North America. Conclusions: This is the largest epidemiological study of ATLL in the United States and shows a rising incidence in New York City. NHBs have a younger age at presentation and poor overall survival. The rising incidence is largely due to NHBs originating from the Caribbean.

Original languageEnglish (US)
JournalCancer
DOIs
StateAccepted/In press - Jan 1 2019

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Adult T Cell Leukemia Lymphoma
Epidemiology
Incidence
Registries
SEER Program
Deltaretrovirus
Neoplasms
North America
Epidemiologic Studies
Survival Rate

Keywords

  • adult T cell
  • and End Results (SEER)
  • epidemiology
  • Epidemiology
  • human T-cell leukemia virus
  • leukemia/lymphoma
  • National Program of Cancer Registries (NPCR)
  • New York
  • New York State Cancer Registry (NYSCR)
  • non-Hodgkin lymphoma
  • Surveillance
  • survival
  • United States

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Shah, U. A., Shah, N., Qiao, B., Acuna-Villaorduna, A., Pradhan, K., Adrianzen Herrera, D., ... Janakiram, M. (Accepted/In press). Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States. Cancer. https://doi.org/10.1002/cncr.32556

Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States. / Shah, Urvi A.; Shah, Nishi; Qiao, Baozhen; Acuna-Villaorduna, Ana; Pradhan, Kith; Adrianzen Herrera, Diego; Sica, R. Alejandro; Shastri, Aditi; Mantzaris, Ioannis; Derman, Olga; Kornblum, Noah; Braunschweig, Ira; Ye, B. Hilda; Verma, Amit; Janakiram, Murali.

In: Cancer, 01.01.2019.

Research output: Contribution to journalArticle

Shah, UA, Shah, N, Qiao, B, Acuna-Villaorduna, A, Pradhan, K, Adrianzen Herrera, D, Sica, RA, Shastri, A, Mantzaris, I, Derman, O, Kornblum, N, Braunschweig, I, Ye, BH, Verma, A & Janakiram, M 2019, 'Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States', Cancer. https://doi.org/10.1002/cncr.32556
Shah, Urvi A. ; Shah, Nishi ; Qiao, Baozhen ; Acuna-Villaorduna, Ana ; Pradhan, Kith ; Adrianzen Herrera, Diego ; Sica, R. Alejandro ; Shastri, Aditi ; Mantzaris, Ioannis ; Derman, Olga ; Kornblum, Noah ; Braunschweig, Ira ; Ye, B. Hilda ; Verma, Amit ; Janakiram, Murali. / Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States. In: Cancer. 2019.
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title = "Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States",
abstract = "Background: Globally, 5 million to 10 million people are infected with human T-cell leukemia virus type 1, which causes adult T-cell leukemia/lymphoma (ATLL) in 2{\%} to 5{\%} of the carriers. ATLL is a rare but extremely aggressive malignancy that can be challenging to diagnose. Very little data exist on the incidence patterns of ATLL in the United States. Methods: ATLL cases reported to the National Program of Cancer Registries, the Surveillance, Epidemiology, and End Results (SEER) program, and the New York State Cancer Registry were used for the study. Age-adjusted incidence rates were calculated by age, race/ethnicity, sex, and year of diagnosis. The 5-year survival rate was compared among race/ethnicity groups with the SEER data. Results: During 2001-2015, 2148 ATLL cases were diagnosed in the United States, 18{\%} of which were in New York State. New York State had the highest incidence rate for ATLL, with a rising trend especially among non-Hispanic blacks (NHBs), whereas the incidence was stable across the remainder of the United States. NHBs were diagnosed at a younger median age (54 years) and had a shorter overall survival (6 months). In New York City, only 22.6{\%} of the ATLL cases diagnosed were born in North America. Conclusions: This is the largest epidemiological study of ATLL in the United States and shows a rising incidence in New York City. NHBs have a younger age at presentation and poor overall survival. The rising incidence is largely due to NHBs originating from the Caribbean.",
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author = "Shah, {Urvi A.} and Nishi Shah and Baozhen Qiao and Ana Acuna-Villaorduna and Kith Pradhan and {Adrianzen Herrera}, Diego and Sica, {R. Alejandro} and Aditi Shastri and Ioannis Mantzaris and Olga Derman and Noah Kornblum and Ira Braunschweig and Ye, {B. Hilda} and Amit Verma and Murali Janakiram",
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T1 - Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States

AU - Shah, Urvi A.

AU - Shah, Nishi

AU - Qiao, Baozhen

AU - Acuna-Villaorduna, Ana

AU - Pradhan, Kith

AU - Adrianzen Herrera, Diego

AU - Sica, R. Alejandro

AU - Shastri, Aditi

AU - Mantzaris, Ioannis

AU - Derman, Olga

AU - Kornblum, Noah

AU - Braunschweig, Ira

AU - Ye, B. Hilda

AU - Verma, Amit

AU - Janakiram, Murali

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Globally, 5 million to 10 million people are infected with human T-cell leukemia virus type 1, which causes adult T-cell leukemia/lymphoma (ATLL) in 2% to 5% of the carriers. ATLL is a rare but extremely aggressive malignancy that can be challenging to diagnose. Very little data exist on the incidence patterns of ATLL in the United States. Methods: ATLL cases reported to the National Program of Cancer Registries, the Surveillance, Epidemiology, and End Results (SEER) program, and the New York State Cancer Registry were used for the study. Age-adjusted incidence rates were calculated by age, race/ethnicity, sex, and year of diagnosis. The 5-year survival rate was compared among race/ethnicity groups with the SEER data. Results: During 2001-2015, 2148 ATLL cases were diagnosed in the United States, 18% of which were in New York State. New York State had the highest incidence rate for ATLL, with a rising trend especially among non-Hispanic blacks (NHBs), whereas the incidence was stable across the remainder of the United States. NHBs were diagnosed at a younger median age (54 years) and had a shorter overall survival (6 months). In New York City, only 22.6% of the ATLL cases diagnosed were born in North America. Conclusions: This is the largest epidemiological study of ATLL in the United States and shows a rising incidence in New York City. NHBs have a younger age at presentation and poor overall survival. The rising incidence is largely due to NHBs originating from the Caribbean.

AB - Background: Globally, 5 million to 10 million people are infected with human T-cell leukemia virus type 1, which causes adult T-cell leukemia/lymphoma (ATLL) in 2% to 5% of the carriers. ATLL is a rare but extremely aggressive malignancy that can be challenging to diagnose. Very little data exist on the incidence patterns of ATLL in the United States. Methods: ATLL cases reported to the National Program of Cancer Registries, the Surveillance, Epidemiology, and End Results (SEER) program, and the New York State Cancer Registry were used for the study. Age-adjusted incidence rates were calculated by age, race/ethnicity, sex, and year of diagnosis. The 5-year survival rate was compared among race/ethnicity groups with the SEER data. Results: During 2001-2015, 2148 ATLL cases were diagnosed in the United States, 18% of which were in New York State. New York State had the highest incidence rate for ATLL, with a rising trend especially among non-Hispanic blacks (NHBs), whereas the incidence was stable across the remainder of the United States. NHBs were diagnosed at a younger median age (54 years) and had a shorter overall survival (6 months). In New York City, only 22.6% of the ATLL cases diagnosed were born in North America. Conclusions: This is the largest epidemiological study of ATLL in the United States and shows a rising incidence in New York City. NHBs have a younger age at presentation and poor overall survival. The rising incidence is largely due to NHBs originating from the Caribbean.

KW - adult T cell

KW - and End Results (SEER)

KW - epidemiology

KW - Epidemiology

KW - human T-cell leukemia virus

KW - leukemia/lymphoma

KW - National Program of Cancer Registries (NPCR)

KW - New York

KW - New York State Cancer Registry (NYSCR)

KW - non-Hodgkin lymphoma

KW - Surveillance

KW - survival

KW - United States

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JF - Cancer

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