TY - JOUR
T1 - Eosinophilic variant of chronic myeloid leukemia with vascular complications
AU - Gotlib, Vladimir
AU - Darji, Jaykrishna
AU - Bloomfield, Kimberly
AU - Chadburn, Amy
AU - Patel, Arun
AU - Braunschweig, Ira
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Eosinophilic variant of CML (eoCML) is a unique disease with a poor prognosis. Like the hypereosinophilic syndrome (HES), eoCML has no clinically identifiable reason for an increased eosinophil count in the peripheral blood. In contrast to HES, eoCML patients carry a distinct chromosomal abnormality. The bcr/abl fusion gene (Philadelphia chromosome) is the genetic basis of this clonal disease. Recently, eoCML has been separated from HES. Patients with eoCML frequently suffer organ damage including the heart and lungs. This damage is related to the release of eosinophilic granules in the blood, which results in fibrosis of the endothelial lining. We report a case of a peripheral vasculitis complicated by gangrene of the fingers in a patient with eoCML. Despite an almost complete response to CML treatment with Gleevac, combined with prednisone, aspirin and coumadin the patient sustained irreversible damage to the vascular lining of the distal arteries of the upper extremities.
AB - Eosinophilic variant of CML (eoCML) is a unique disease with a poor prognosis. Like the hypereosinophilic syndrome (HES), eoCML has no clinically identifiable reason for an increased eosinophil count in the peripheral blood. In contrast to HES, eoCML patients carry a distinct chromosomal abnormality. The bcr/abl fusion gene (Philadelphia chromosome) is the genetic basis of this clonal disease. Recently, eoCML has been separated from HES. Patients with eoCML frequently suffer organ damage including the heart and lungs. This damage is related to the release of eosinophilic granules in the blood, which results in fibrosis of the endothelial lining. We report a case of a peripheral vasculitis complicated by gangrene of the fingers in a patient with eoCML. Despite an almost complete response to CML treatment with Gleevac, combined with prednisone, aspirin and coumadin the patient sustained irreversible damage to the vascular lining of the distal arteries of the upper extremities.
KW - Chronic myelogenous leukemia
KW - Eosinophilia
KW - Hypereosinophilic syndrome
KW - Vascular complications
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U2 - 10.1080/1042819031000156748
DO - 10.1080/1042819031000156748
M3 - Article
C2 - 14565666
AN - SCOPUS:0038574498
SN - 1042-8194
VL - 44
SP - 1609
EP - 1613
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 9
ER -