Eosinophilic variant of chronic myeloid leukemia with vascular complications

Vladimir Gotlib, Jaykrishna Darji, Kimberly Bloomfield, Amy Chadburn, Arun Patel, Ira Braunschweig

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Eosinophilic variant of CML (eoCML) is a unique disease with a poor prognosis. Like the hypereosinophilic syndrome (HES), eoCML has no clinically identifiable reason for an increased eosinophil count in the peripheral blood. In contrast to HES, eoCML patients carry a distinct chromosomal abnormality. The bcr/abl fusion gene (Philadelphia chromosome) is the genetic basis of this clonal disease. Recently, eoCML has been separated from HES. Patients with eoCML frequently suffer organ damage including the heart and lungs. This damage is related to the release of eosinophilic granules in the blood, which results in fibrosis of the endothelial lining. We report a case of a peripheral vasculitis complicated by gangrene of the fingers in a patient with eoCML. Despite an almost complete response to CML treatment with Gleevac, combined with prednisone, aspirin and coumadin the patient sustained irreversible damage to the vascular lining of the distal arteries of the upper extremities.

Original languageEnglish (US)
Pages (from-to)1609-1613
Number of pages5
JournalLeukemia and Lymphoma
Volume44
Issue number9
DOIs
StatePublished - Sep 1 2003

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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Hypereosinophilic Syndrome
Blood Vessels
abl Genes
Philadelphia Chromosome
Gangrene
Warfarin
Vasculitis
Prednisone
Eosinophils
Upper Extremity
Chromosome Aberrations
Aspirin
Fingers
Fibrosis
Arteries
Lung
Therapeutics

Keywords

  • Chronic myelogenous leukemia
  • Eosinophilia
  • Hypereosinophilic syndrome
  • Vascular complications

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Eosinophilic variant of chronic myeloid leukemia with vascular complications. / Gotlib, Vladimir; Darji, Jaykrishna; Bloomfield, Kimberly; Chadburn, Amy; Patel, Arun; Braunschweig, Ira.

In: Leukemia and Lymphoma, Vol. 44, No. 9, 01.09.2003, p. 1609-1613.

Research output: Contribution to journalArticle

Gotlib, Vladimir ; Darji, Jaykrishna ; Bloomfield, Kimberly ; Chadburn, Amy ; Patel, Arun ; Braunschweig, Ira. / Eosinophilic variant of chronic myeloid leukemia with vascular complications. In: Leukemia and Lymphoma. 2003 ; Vol. 44, No. 9. pp. 1609-1613.
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