Enhancing clinical trial development for pediatric kidney diseases

H. William Schnaper; Joseph T. Flynn; Coleman Gross; Anne B. Cropp; Bastian Dehmel; Leah B. Patel; Larry A. Greenbaum; Elisabeth Houtsmuller; Frederick Kaskel; Marva Moxey-Mims; Karen Nowak; Douglas Silverstein; Aliza Thompson; Lynne Yao; Edress Darsey; William E. Smoyer

doi:10.1038/pr.2017.180

Enhancing clinical trial development for pediatric kidney diseases

H. William Schnaper, Joseph T. Flynn, Coleman Gross, Anne B. Cropp, Bastian Dehmel, Leah B. Patel, Larry A. Greenbaum, Elisabeth Houtsmuller, Frederick Kaskel, Marva Moxey-Mims, Karen Nowak, Douglas Silverstein, Aliza Thompson, Lynne Yao, Edress Darsey, William E. Smoyer

Pediatrics

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The conduct of clinical trials in small pediatric subspecialties such as pediatric nephrology is hampered by both clinical demands on the pediatric nephrologist and the small number of appropriate patients available for such studies. The American Society of Pediatric Nephrology Therapeutics Development Committee (TDC) was established to (1) identify the various stakeholders with interests and/or expertise related to clinical trials in children with kidney disease and (2) develop more effective partnerships among all parties regarding strategies for successful clinical trial development and execution. This article discusses the rationale, structure, and function of the TDC, the status of progress toward its goals, and the insights gained to date that may be useful for other subspecialties that face similar challenges.

Original language	English (US)
Pages (from-to)	727-732
Number of pages	6
Journal	Pediatric Research
Volume	82
Issue number	5
DOIs	https://doi.org/10.1038/pr.2017.180
State	Published - Nov 1 2017

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1038/pr.2017.180

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Schnaper, H. W., Flynn, J. T., Gross, C., Cropp, A. B., Dehmel, B., Patel, L. B., Greenbaum, L. A., Houtsmuller, E., Kaskel, F., Moxey-Mims, M., Nowak, K., Silverstein, D., Thompson, A., Yao, L., Darsey, E., & Smoyer, W. E. (2017). Enhancing clinical trial development for pediatric kidney diseases. Pediatric Research, 82(5), 727-732. https://doi.org/10.1038/pr.2017.180

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abstract = "The conduct of clinical trials in small pediatric subspecialties such as pediatric nephrology is hampered by both clinical demands on the pediatric nephrologist and the small number of appropriate patients available for such studies. The American Society of Pediatric Nephrology Therapeutics Development Committee (TDC) was established to (1) identify the various stakeholders with interests and/or expertise related to clinical trials in children with kidney disease and (2) develop more effective partnerships among all parties regarding strategies for successful clinical trial development and execution. This article discusses the rationale, structure, and function of the TDC, the status of progress toward its goals, and the insights gained to date that may be useful for other subspecialties that face similar challenges.",

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AU - Schnaper, H. William

AU - Flynn, Joseph T.

AU - Gross, Coleman

AU - Cropp, Anne B.

AU - Dehmel, Bastian

AU - Patel, Leah B.

AU - Greenbaum, Larry A.

AU - Houtsmuller, Elisabeth

AU - Kaskel, Frederick

AU - Moxey-Mims, Marva

AU - Nowak, Karen

AU - Silverstein, Douglas

AU - Thompson, Aliza

AU - Yao, Lynne

AU - Darsey, Edress

AU - Smoyer, William E.

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AB - The conduct of clinical trials in small pediatric subspecialties such as pediatric nephrology is hampered by both clinical demands on the pediatric nephrologist and the small number of appropriate patients available for such studies. The American Society of Pediatric Nephrology Therapeutics Development Committee (TDC) was established to (1) identify the various stakeholders with interests and/or expertise related to clinical trials in children with kidney disease and (2) develop more effective partnerships among all parties regarding strategies for successful clinical trial development and execution. This article discusses the rationale, structure, and function of the TDC, the status of progress toward its goals, and the insights gained to date that may be useful for other subspecialties that face similar challenges.

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JO - Pediatric Research

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Enhancing clinical trial development for pediatric kidney diseases

Abstract

ASJC Scopus subject areas

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