Enhanced cancer cell killing by a targeting gold nanoconstruct with doxorubicin payload under X-ray irradiation

Hongyu Zhou, Yi Zhang, Gaoxing Su, Shumei Zhai, Bing Yan

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

In this report, a cancer-targeting nanoconstruct enters a cancer cell four times more readily than non-targeting nanoparticles. Inside the cell, the nanoconstruct conducts a double DNA attack from a DNA intercalating drug doxorubicin and radiation-enhancing gold nanoparticles achieving 2.5 fold higher DNA double strand breakage in the cancer genome. An overall 4.0 or 2.7-fold increase in cancer cell killing was achieved compared to the free drug without or with X-ray irradiation and a significant reduction in nonspecific toxicity to folate receptor-negative cells demonstrated the unique advantage of a nanomedicine approach to future chemotherapy and radiotherapy.

Original languageEnglish (US)
Pages (from-to)21596-21603
Number of pages8
JournalRSC Advances
Volume3
Issue number44
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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