Abstract
In this report, a cancer-targeting nanoconstruct enters a cancer cell four times more readily than non-targeting nanoparticles. Inside the cell, the nanoconstruct conducts a double DNA attack from a DNA intercalating drug doxorubicin and radiation-enhancing gold nanoparticles achieving 2.5 fold higher DNA double strand breakage in the cancer genome. An overall 4.0 or 2.7-fold increase in cancer cell killing was achieved compared to the free drug without or with X-ray irradiation and a significant reduction in nonspecific toxicity to folate receptor-negative cells demonstrated the unique advantage of a nanomedicine approach to future chemotherapy and radiotherapy.
Original language | English (US) |
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Pages (from-to) | 21596-21603 |
Number of pages | 8 |
Journal | RSC Advances |
Volume | 3 |
Issue number | 44 |
DOIs | |
State | Published - 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering