TY - JOUR
T1 - Endogenous cannabinoid signaling at inhibitory interneurons
AU - Younts, Thomas J.
AU - Castillo, Pablo E.
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Significant progress has been made in our understanding of how endogenous cannabinoids (eCBs) signal at excitatory and inhibitory synapses in the central nervous system (CNS). This review discusses how eCBs regulate inhibitory interneurons, their synapses, and the networks in which they are embedded. eCB signaling plays a pivotal role in brain physiology by means of their synaptic signal transduction, spatiotemporal signaling profile, routing of information through inhibitory microcircuits, and experience-dependent plasticity. Understanding the normal processes underlying eCB signaling is beginning to shed light on how their dysregulation contributes to disease.
AB - Significant progress has been made in our understanding of how endogenous cannabinoids (eCBs) signal at excitatory and inhibitory synapses in the central nervous system (CNS). This review discusses how eCBs regulate inhibitory interneurons, their synapses, and the networks in which they are embedded. eCB signaling plays a pivotal role in brain physiology by means of their synaptic signal transduction, spatiotemporal signaling profile, routing of information through inhibitory microcircuits, and experience-dependent plasticity. Understanding the normal processes underlying eCB signaling is beginning to shed light on how their dysregulation contributes to disease.
UR - http://www.scopus.com/inward/record.url?scp=84891092161&partnerID=8YFLogxK
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U2 - 10.1016/j.conb.2013.12.006
DO - 10.1016/j.conb.2013.12.006
M3 - Review article
C2 - 24650503
AN - SCOPUS:84891092161
VL - 26
SP - 42
EP - 50
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
ER -