Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

Irfan A. Qureshi, Mark F. Mehler

Research output: Contribution to journalReview article

342 Scopus citations

Abstract

Novel classes of small and long non-coding RNAs (ncRNAs) are being characterized at a rapid pace, driven by recent paradigm shifts in our understanding of genomic architecture, regulation and transcriptional output, as well as by innovations in sequencing technologies and computational and systems biology. These ncRNAs can interact with DNA, RNA and protein molecules; engage in diverse structural, functional and regulatory activities; and have roles in nuclear organization and transcriptional, post-transcriptional and epigenetic processes. This expanding inventory of ncRNAs is implicated in mediating a broad spectrum of processes including brain evolution, development, synaptic plasticity and disease pathogenesis.

Original languageEnglish (US)
Pages (from-to)528-541
Number of pages14
JournalNature Reviews Neuroscience
Volume13
Issue number8
DOIs
StatePublished - Aug 1 2012

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ASJC Scopus subject areas

  • Neuroscience(all)

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