Emerging roles of linker histones in regulating chromatin structure and function

Dmitry Fyodorov, Bing Rui Zhou, Arthur I. Skoultchi, Yawen Bai

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

Together with core histones, which make up the nucleosome, the linker histone (H1) is one of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to the nucleosome to form the next structural unit of metazoan chromatin, the chromatosome, which may help chromatin to fold into higher-order structures. Despite their important roles in regulating the structure and function of chromatin, linker histones have not been studied as extensively as core histones. Nevertheless, substantial progress has been made recently. The first near-atomic resolution crystal structure of a chromatosome core particle and an 11 Å resolution cryo-electron microscopy-derived structure of the 30 nm nucleosome array have been determined, revealing unprecedented details about how linker histones interact with the nucleosome and organize higher-order chromatin structures. Moreover, several new functions of linker histones have been discovered, including their roles in epigenetic regulation and the regulation of DNA replication, DNA repair and genome stability. Studies of the molecular mechanisms of H1 action in these processes suggest a new paradigm for linker histone function beyond its architectural roles in chromatin.

Original languageEnglish (US)
Pages (from-to)192-206
Number of pages15
JournalNature Reviews Molecular Cell Biology
Volume19
Issue number3
DOIs
StatePublished - Mar 1 2018

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Histones
Chromatin
Nucleosomes
Cryoelectron Microscopy
Genomic Instability
Eukaryotic Cells
DNA Replication
Epigenomics
DNA Repair
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Emerging roles of linker histones in regulating chromatin structure and function. / Fyodorov, Dmitry; Zhou, Bing Rui; Skoultchi, Arthur I.; Bai, Yawen.

In: Nature Reviews Molecular Cell Biology, Vol. 19, No. 3, 01.03.2018, p. 192-206.

Research output: Contribution to journalReview article

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