Abstract
Hyperparathyroidism persisted in a 36 yr old woman after surgical exploration of the neck and removal of 2 1/2 normal parathyroid glands. Arteriography, selective venous sampling and radioimmunoassay allowed identification of the source of excess parathyroid hormone (PTH) as a mediastinal lesion at the level of the tracheal bifurcation. The artery feeding the lesion was deliberately compromised by embolic occlusion with a mixture of autologous clot and gelfoam. This procedure led to transient hypoparathyroidism. Serial monitoring of plasma parathyroid hormone levels, renal phosphate clearance, and urinary cyclic adenosine monophosphate excretion indicated that parathyroid ischemia had not resulted in release of large amounts of biologically or immunologically active parathyroid hormone. Within 5 days after the procedure the concentration of parathyroid hormone in plasma increased indicating the presence of residual parathyroid tissue in the neck or mediastinum. Mild hyperparathyroidism reappeared within several months with less marked elevations of PTH and calcium levels suggesting that the tumor had not infarcted completely.
Original language | English (US) |
---|---|
Pages (from-to) | 1110-11114 |
Number of pages | 10005 |
Journal | Journal of Clinical Endocrinology and Metabolism |
Volume | 39 |
Issue number | 6 |
State | Published - 1974 |
Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Embolization of a mediastinal parathyroid adenoma. / Marx, S. J.; Doppman, J. L.; Spiegel, Allen M.; Wolfe, D.; Aurbach, G. D.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 39, No. 6, 1974, p. 1110-11114.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Embolization of a mediastinal parathyroid adenoma
AU - Marx, S. J.
AU - Doppman, J. L.
AU - Spiegel, Allen M.
AU - Wolfe, D.
AU - Aurbach, G. D.
PY - 1974
Y1 - 1974
N2 - Hyperparathyroidism persisted in a 36 yr old woman after surgical exploration of the neck and removal of 2 1/2 normal parathyroid glands. Arteriography, selective venous sampling and radioimmunoassay allowed identification of the source of excess parathyroid hormone (PTH) as a mediastinal lesion at the level of the tracheal bifurcation. The artery feeding the lesion was deliberately compromised by embolic occlusion with a mixture of autologous clot and gelfoam. This procedure led to transient hypoparathyroidism. Serial monitoring of plasma parathyroid hormone levels, renal phosphate clearance, and urinary cyclic adenosine monophosphate excretion indicated that parathyroid ischemia had not resulted in release of large amounts of biologically or immunologically active parathyroid hormone. Within 5 days after the procedure the concentration of parathyroid hormone in plasma increased indicating the presence of residual parathyroid tissue in the neck or mediastinum. Mild hyperparathyroidism reappeared within several months with less marked elevations of PTH and calcium levels suggesting that the tumor had not infarcted completely.
AB - Hyperparathyroidism persisted in a 36 yr old woman after surgical exploration of the neck and removal of 2 1/2 normal parathyroid glands. Arteriography, selective venous sampling and radioimmunoassay allowed identification of the source of excess parathyroid hormone (PTH) as a mediastinal lesion at the level of the tracheal bifurcation. The artery feeding the lesion was deliberately compromised by embolic occlusion with a mixture of autologous clot and gelfoam. This procedure led to transient hypoparathyroidism. Serial monitoring of plasma parathyroid hormone levels, renal phosphate clearance, and urinary cyclic adenosine monophosphate excretion indicated that parathyroid ischemia had not resulted in release of large amounts of biologically or immunologically active parathyroid hormone. Within 5 days after the procedure the concentration of parathyroid hormone in plasma increased indicating the presence of residual parathyroid tissue in the neck or mediastinum. Mild hyperparathyroidism reappeared within several months with less marked elevations of PTH and calcium levels suggesting that the tumor had not infarcted completely.
UR - http://www.scopus.com/inward/record.url?scp=0016357656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016357656&partnerID=8YFLogxK
M3 - Article
C2 - 4372246
AN - SCOPUS:0016357656
VL - 39
SP - 1110
EP - 11114
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 6
ER -