Elevated serum interleukin-1β levels and interleukin-1β-to-interleukin-1 receptor antagonist ratio 1 week after embryo transfer are associated with ectopic pregnancy

Jovana Lekovich, Steven S. Witkin, Georgios Doulaveris, Theofano Orfanelli, Brittney Shulman, Nigel Pereira, Zev Rosenwaks, Steven D. Spandorfer

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Objective To investigate whether interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1RA) serum levels in the early luteal phase differ in IVF cycles that result in an ectopic pregnancy (EP) when compared with other outcomes. Design Retrospective cohort. Setting Not applicable. Patient(s) A total of 307 women whose serum samples were available, with the following IVF outcomes: 103 live births, 80 negative pregnancy tests, 52 biochemical pregnancies, 47 EPs, and 25 miscarriages. Intervention(s) Serum samples were obtained on cycle days 24 and 28 (cycle day 14 = day of egg retrieval). Levels of IL-1β and IL-1RA were determined by quantitative ELISA performed by blinded personnel. Main Outcome Measure(s) IL-1β and IL-1RA levels, IL-1β-to-IL-1RA ratio versus cycle outcome. Result(s) The IL-1β levels were predictive of an EP. At cycle days 24 and 28 the mean IL-1β levels were higher in patients with an EP (127.1 pg/mL and 166.9 pg/mL, respectively) than in women with any other IVF outcome (15.8-55.3 pg/mL and 14.8-75.5 pg/mL, respectively). At cycle day 24 the IL-1β-to-IL-1RA ratio was 0.18 in the ectopic group versus 0.01-0.09 in the other groups. Conclusion(s) Elevated IL-1β levels and IL-1β-to-IL-1RA ratio as early as 4 days before the first pregnancy test are associated with an EP. If confirmed by prospective studies, clinical application of these findings could potentially improve EP detection.

Original languageEnglish (US)
Pages (from-to)1190-1194
Number of pages5
JournalFertility and sterility
Volume104
Issue number5
DOIs
StatePublished - Nov 2015
Externally publishedYes

Keywords

  • IVF
  • Interleukin 1β
  • ectopic pregnancy
  • interleukin-1 receptor antagonist

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint

Dive into the research topics of 'Elevated serum interleukin-1β levels and interleukin-1β-to-interleukin-1 receptor antagonist ratio 1 week after embryo transfer are associated with ectopic pregnancy'. Together they form a unique fingerprint.

Cite this