Electrophysiologic Properties of Morphine in Man

Lawrence Gould; C. V. Ramana Reddy; Oh Keun-Chang; Soo Gyum Kim

doi:10.1177/000331977802900802

Electrophysiologic Properties of Morphine in Man

Lawrence Gould, C. V. Ramana Reddy, Oh Keun-Chang, Soo Gyum Kim

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

His bundle electrograms were recorded in 13 patients before and 20 minutes after morphine administration. Recordings were made at various rates utilizing right atrial pacing. Morphine did not alter the HQ intervals. However there were variable effects on the AH intervals as well as on the effective refractory period of the AV node. These results can be explained by the interplay of two factors, catecholamine release and a direct depressant action of the drug. Conduction through the AV node will be improved or delayed, depending on which factor is dominant.

Original language	English (US)
Pages (from-to)	579-588
Number of pages	10
Journal	Angiology
Volume	29
Issue number	8
DOIs	https://doi.org/10.1177/000331977802900802
State	Published - Aug 1978
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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abstract = "His bundle electrograms were recorded in 13 patients before and 20 minutes after morphine administration. Recordings were made at various rates utilizing right atrial pacing. Morphine did not alter the HQ intervals. However there were variable effects on the AH intervals as well as on the effective refractory period of the AV node. These results can be explained by the interplay of two factors, catecholamine release and a direct depressant action of the drug. Conduction through the AV node will be improved or delayed, depending on which factor is dominant.",

author = "Lawrence Gould and {Ramana Reddy}, {C. V.} and Oh Keun-Chang and {Gyum Kim}, Soo",

year = "1978",

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N2 - His bundle electrograms were recorded in 13 patients before and 20 minutes after morphine administration. Recordings were made at various rates utilizing right atrial pacing. Morphine did not alter the HQ intervals. However there were variable effects on the AH intervals as well as on the effective refractory period of the AV node. These results can be explained by the interplay of two factors, catecholamine release and a direct depressant action of the drug. Conduction through the AV node will be improved or delayed, depending on which factor is dominant.

AB - His bundle electrograms were recorded in 13 patients before and 20 minutes after morphine administration. Recordings were made at various rates utilizing right atrial pacing. Morphine did not alter the HQ intervals. However there were variable effects on the AH intervals as well as on the effective refractory period of the AV node. These results can be explained by the interplay of two factors, catecholamine release and a direct depressant action of the drug. Conduction through the AV node will be improved or delayed, depending on which factor is dominant.

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Electrophysiologic Properties of Morphine in Man

Abstract

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