Electrocardiograms in Healthy North American Children in the Digital Age

Pediatric Heart Network Investigators*

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: Interpretation of pediatric ECGs is limited by lack of accurate sex- and race-specific normal reference values obtained with modern technology for all ages. We sought to obtain contemporary digital ECG measurements in healthy children from North America, to evaluate the effects of sex and race, and to compare our results to commonly used published datasets.

METHODS: Digital ECGs (12-lead) were retrospectively collected for children ≤18 years old with normal echocardiograms at 19 centers in the Pediatric Heart Network. Patients were classified into 36 groups: 6 age, 2 sex, and 3 race (white, black, and other/mixed) categories. Standard intervals and amplitudes were measured; mean±SD and 2nd/98th percentiles were determined by age group, sex, and race. For each parameter, multivariable analysis, stratified by age, was conducted using sex and race as predictors. Parameters were compared with 2 large pediatric ECG data sets.

RESULTS: Among ECGs from 2400 children, significant differences were found by sex and race categories. The corrected QT interval in lead II was greater for girls compared with boys for age groups ≥3 years (P≤0.03) and for whites compared with blacks for age groups ≥12 years (P<0.05). The R wave amplitude in V6 was greater for boys compared with girls for age groups ≥12 years (P<0.001), for blacks compared with white or other race categories for age groups ≥3 years (P≤0.006), and greater compared with a commonly used public data set for age groups ≥12 years (P<0.0001).

CONCLUSIONS: In this large, diverse cohort of healthy children, most ECG intervals and amplitudes varied by sex and race. These differences have important implications for interpreting pediatric ECGs in the modern era when used for diagnosis or screening, including thresholds for left ventricular hypertrophy.

Original languageEnglish (US)
Pages (from-to)e005808
JournalCirculation. Arrhythmia and electrophysiology
Volume11
Issue number7
DOIs
StatePublished - Jul 1 2018
Externally publishedYes

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Electrocardiography
Age Groups
Pediatrics
Reference Values
Left Ventricular Hypertrophy
North America
Technology
Datasets

Keywords

  • electrocardiography
  • hypertrophy, left ventricular
  • pediatrics
  • reference value

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Electrocardiograms in Healthy North American Children in the Digital Age. / Pediatric Heart Network Investigators*.

In: Circulation. Arrhythmia and electrophysiology, Vol. 11, No. 7, 01.07.2018, p. e005808.

Research output: Contribution to journalArticle

Pediatric Heart Network Investigators*. / Electrocardiograms in Healthy North American Children in the Digital Age. In: Circulation. Arrhythmia and electrophysiology. 2018 ; Vol. 11, No. 7. pp. e005808.
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abstract = "BACKGROUND: Interpretation of pediatric ECGs is limited by lack of accurate sex- and race-specific normal reference values obtained with modern technology for all ages. We sought to obtain contemporary digital ECG measurements in healthy children from North America, to evaluate the effects of sex and race, and to compare our results to commonly used published datasets.METHODS: Digital ECGs (12-lead) were retrospectively collected for children ≤18 years old with normal echocardiograms at 19 centers in the Pediatric Heart Network. Patients were classified into 36 groups: 6 age, 2 sex, and 3 race (white, black, and other/mixed) categories. Standard intervals and amplitudes were measured; mean±SD and 2nd/98th percentiles were determined by age group, sex, and race. For each parameter, multivariable analysis, stratified by age, was conducted using sex and race as predictors. Parameters were compared with 2 large pediatric ECG data sets.RESULTS: Among ECGs from 2400 children, significant differences were found by sex and race categories. The corrected QT interval in lead II was greater for girls compared with boys for age groups ≥3 years (P≤0.03) and for whites compared with blacks for age groups ≥12 years (P<0.05). The R wave amplitude in V6 was greater for boys compared with girls for age groups ≥12 years (P<0.001), for blacks compared with white or other race categories for age groups ≥3 years (P≤0.006), and greater compared with a commonly used public data set for age groups ≥12 years (P<0.0001).CONCLUSIONS: In this large, diverse cohort of healthy children, most ECG intervals and amplitudes varied by sex and race. These differences have important implications for interpreting pediatric ECGs in the modern era when used for diagnosis or screening, including thresholds for left ventricular hypertrophy.",
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author = "{Pediatric Heart Network Investigators*} and Saarel, {Elizabeth V.} and Suzanne Granger and Kaltman, {Jonathan R.} and Minich, {L. Lu Ann} and Martin Tristani-Firouzi and Kim, {Jeffrey J.} and Kathleen Ash and Tsao, {Sabrina S.} and Berul, {Charles I.} and Stephenson, {Elizabeth A.} and Gamboa, {David G.} and Felicia Trachtenberg and Peter Fischbach and Vetter, {Victoria L.} and Czosek, {Richard J.} and Johnson, {Tiffanie R.} and Salerno, {Jack C.} and Cain, {Nicole B.} and Pass, {Robert H.} and Ilana Zeltser and Silver, {Eric S.} and Kovach, {Joshua R.} and Alexander, {Mark E.}",
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AU - Pediatric Heart Network Investigators

AU - Saarel, Elizabeth V.

AU - Granger, Suzanne

AU - Kaltman, Jonathan R.

AU - Minich, L. Lu Ann

AU - Tristani-Firouzi, Martin

AU - Kim, Jeffrey J.

AU - Ash, Kathleen

AU - Tsao, Sabrina S.

AU - Berul, Charles I.

AU - Stephenson, Elizabeth A.

AU - Gamboa, David G.

AU - Trachtenberg, Felicia

AU - Fischbach, Peter

AU - Vetter, Victoria L.

AU - Czosek, Richard J.

AU - Johnson, Tiffanie R.

AU - Salerno, Jack C.

AU - Cain, Nicole B.

AU - Pass, Robert H.

AU - Zeltser, Ilana

AU - Silver, Eric S.

AU - Kovach, Joshua R.

AU - Alexander, Mark E.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - BACKGROUND: Interpretation of pediatric ECGs is limited by lack of accurate sex- and race-specific normal reference values obtained with modern technology for all ages. We sought to obtain contemporary digital ECG measurements in healthy children from North America, to evaluate the effects of sex and race, and to compare our results to commonly used published datasets.METHODS: Digital ECGs (12-lead) were retrospectively collected for children ≤18 years old with normal echocardiograms at 19 centers in the Pediatric Heart Network. Patients were classified into 36 groups: 6 age, 2 sex, and 3 race (white, black, and other/mixed) categories. Standard intervals and amplitudes were measured; mean±SD and 2nd/98th percentiles were determined by age group, sex, and race. For each parameter, multivariable analysis, stratified by age, was conducted using sex and race as predictors. Parameters were compared with 2 large pediatric ECG data sets.RESULTS: Among ECGs from 2400 children, significant differences were found by sex and race categories. The corrected QT interval in lead II was greater for girls compared with boys for age groups ≥3 years (P≤0.03) and for whites compared with blacks for age groups ≥12 years (P<0.05). The R wave amplitude in V6 was greater for boys compared with girls for age groups ≥12 years (P<0.001), for blacks compared with white or other race categories for age groups ≥3 years (P≤0.006), and greater compared with a commonly used public data set for age groups ≥12 years (P<0.0001).CONCLUSIONS: In this large, diverse cohort of healthy children, most ECG intervals and amplitudes varied by sex and race. These differences have important implications for interpreting pediatric ECGs in the modern era when used for diagnosis or screening, including thresholds for left ventricular hypertrophy.

AB - BACKGROUND: Interpretation of pediatric ECGs is limited by lack of accurate sex- and race-specific normal reference values obtained with modern technology for all ages. We sought to obtain contemporary digital ECG measurements in healthy children from North America, to evaluate the effects of sex and race, and to compare our results to commonly used published datasets.METHODS: Digital ECGs (12-lead) were retrospectively collected for children ≤18 years old with normal echocardiograms at 19 centers in the Pediatric Heart Network. Patients were classified into 36 groups: 6 age, 2 sex, and 3 race (white, black, and other/mixed) categories. Standard intervals and amplitudes were measured; mean±SD and 2nd/98th percentiles were determined by age group, sex, and race. For each parameter, multivariable analysis, stratified by age, was conducted using sex and race as predictors. Parameters were compared with 2 large pediatric ECG data sets.RESULTS: Among ECGs from 2400 children, significant differences were found by sex and race categories. The corrected QT interval in lead II was greater for girls compared with boys for age groups ≥3 years (P≤0.03) and for whites compared with blacks for age groups ≥12 years (P<0.05). The R wave amplitude in V6 was greater for boys compared with girls for age groups ≥12 years (P<0.001), for blacks compared with white or other race categories for age groups ≥3 years (P≤0.006), and greater compared with a commonly used public data set for age groups ≥12 years (P<0.0001).CONCLUSIONS: In this large, diverse cohort of healthy children, most ECG intervals and amplitudes varied by sex and race. These differences have important implications for interpreting pediatric ECGs in the modern era when used for diagnosis or screening, including thresholds for left ventricular hypertrophy.

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