Efficacy of Methylprednisolone in Acute Spinal Cord Injury

Michael B. Bracken, William F. Collins, Daniel F. Freeman, Mary Jo Shepard, Franklin W. Wagner, Robert M. Silten, Karen G. Hellenbrand, Joseph Ransohoff, William E. Hunt, Phaner L. Perot, Robert G. Grossman, Barth A. Green, Howard M. Eisenberg, Nathan Rifkinson, Joseph H. Goodman, John N. Meagher, Boguslav Fischer, Guy L. Clifton, Eugene S. Flamm, Stephen E. Rawe

Research output: Contribution to journalArticle

365 Citations (Scopus)

Abstract

A multicenter double-blind randomized trial was conducted to examine the efficacy of a high dose of methylprednisolone (1,000-mg bolus and daily thereafter for ten days) compared with a standard dose (100-mg bolus and daily thereafter for ten days) in 330 patients with acute spinal cord injury. No difference in neurological recovery of motor function or pinprick and light touch sensation was observed between the two treatment groups six weeks and six months after injury. The lack of a treatment effect was independent of the severity of the initial lesion or the time from injury to starting treatment. Although not statistically significant, early case fatality was greater in the high-dose protocol (relative risk of 3.1 and 1.9, ≤ 14 and 15 to 28 days after injury, respectively) but not from 29 to 210 days after injury. Wound infections of both trauma and operative sites were more prevalent in the high-dose regimen (relative risk of 3.6).

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalJAMA - Journal of the American Medical Association
Volume251
Issue number1
DOIs
StatePublished - Jan 6 1984
Externally publishedYes

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Methylprednisolone
Spinal Cord Injuries
Wounds and Injuries
Recovery of Function
Touch
Wound Infection
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bracken, M. B., Collins, W. F., Freeman, D. F., Shepard, M. J., Wagner, F. W., Silten, R. M., ... Rawe, S. E. (1984). Efficacy of Methylprednisolone in Acute Spinal Cord Injury. JAMA - Journal of the American Medical Association, 251(1), 45-52. https://doi.org/10.1001/jama.1984.03340250025015

Efficacy of Methylprednisolone in Acute Spinal Cord Injury. / Bracken, Michael B.; Collins, William F.; Freeman, Daniel F.; Shepard, Mary Jo; Wagner, Franklin W.; Silten, Robert M.; Hellenbrand, Karen G.; Ransohoff, Joseph; Hunt, William E.; Perot, Phaner L.; Grossman, Robert G.; Green, Barth A.; Eisenberg, Howard M.; Rifkinson, Nathan; Goodman, Joseph H.; Meagher, John N.; Fischer, Boguslav; Clifton, Guy L.; Flamm, Eugene S.; Rawe, Stephen E.

In: JAMA - Journal of the American Medical Association, Vol. 251, No. 1, 06.01.1984, p. 45-52.

Research output: Contribution to journalArticle

Bracken, MB, Collins, WF, Freeman, DF, Shepard, MJ, Wagner, FW, Silten, RM, Hellenbrand, KG, Ransohoff, J, Hunt, WE, Perot, PL, Grossman, RG, Green, BA, Eisenberg, HM, Rifkinson, N, Goodman, JH, Meagher, JN, Fischer, B, Clifton, GL, Flamm, ES & Rawe, SE 1984, 'Efficacy of Methylprednisolone in Acute Spinal Cord Injury', JAMA - Journal of the American Medical Association, vol. 251, no. 1, pp. 45-52. https://doi.org/10.1001/jama.1984.03340250025015
Bracken MB, Collins WF, Freeman DF, Shepard MJ, Wagner FW, Silten RM et al. Efficacy of Methylprednisolone in Acute Spinal Cord Injury. JAMA - Journal of the American Medical Association. 1984 Jan 6;251(1):45-52. https://doi.org/10.1001/jama.1984.03340250025015
Bracken, Michael B. ; Collins, William F. ; Freeman, Daniel F. ; Shepard, Mary Jo ; Wagner, Franklin W. ; Silten, Robert M. ; Hellenbrand, Karen G. ; Ransohoff, Joseph ; Hunt, William E. ; Perot, Phaner L. ; Grossman, Robert G. ; Green, Barth A. ; Eisenberg, Howard M. ; Rifkinson, Nathan ; Goodman, Joseph H. ; Meagher, John N. ; Fischer, Boguslav ; Clifton, Guy L. ; Flamm, Eugene S. ; Rawe, Stephen E. / Efficacy of Methylprednisolone in Acute Spinal Cord Injury. In: JAMA - Journal of the American Medical Association. 1984 ; Vol. 251, No. 1. pp. 45-52.
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