Efficacy and safety of catheter ablation for long-standing persistent atrial fibrillation in women

Xiao Dong Zhang, Hong Wei Tan, Jun Gu, Wei Feng Jiang, Liang Zhao, Yuan Long Wang, Yu Gang Liu, Li Zhou, Jia Ning Gu, Xu Liu

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Objectives It is uncertain whether gender affects the outcomes of catheter ablation (CA) for atrial fibrillation (AF). The objective of the study is to evaluate the efficacy and safety of CA for long-standing persistent AF in women. Methods Between January 2010 and May 2011, 220 consecutive patients (73 females, 33.2%), with long-standing persistent AF who underwent CA were prospectively recruited. Gender-related differences in clinical presentation, periprocedural complications, and outcomes were compared. Results Women were less likely to have lone AF than men (27.4% vs 47.6%; P = 0.004). The incidence of rheumatic heart disease was higher in women (19.2% in women vs 1.4% in men; P < 0.001). Women had a lower initial ablation success rate than men (35.6% vs 57.1%; P = 0.003). Hematomas occurred more often in women (6.8% in women vs 0.7% in men; P = 0.027). A Cox regression analysis demonstrated total duration of AF (per month, hazard ratio [HR] 1.003, confidence interval [CI] 1.001-1.006; P = 0.006) and gender (HR 1.663, CI 1.114-2.485; P = 0.013) as the independent predictors for recurrence after the first CA. Conclusions Women and long AF duration were closely related to the recurrence of AF after the first ablation in patients with long-standing persistent AF. Women also had a higher risk of vascular complications.

Original languageEnglish (US)
Pages (from-to)1236-1244
Number of pages9
JournalPACE - Pacing and Clinical Electrophysiology
Issue number10
StatePublished - 2013
Externally publishedYes


  • Atrial fibrillation
  • Catheter ablation
  • Recurrence
  • Women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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