TY - JOUR
T1 - Efficacy and Safety of Calcium Channel Blocker/Diuretics Combination Therapy in Hypertensive Patients
T2 - A Meta-Analysis
AU - Rimoldi, Stefano F.
AU - Messerli, Franz H.
AU - Chavez, Patricia
AU - Stefanini, Giulio G.
AU - Scherrer, Urs
N1 - Publisher Copyright:
©2015 Wiley Periodicals, Inc.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Although recent guidelines recommend the combination of calcium channel blockers (CCBs) and thiazide (-like) diuretics, this combination is not widely used in clinical practice. The aim of this meta-analysis was to assess the efficacy and safety of this combination regarding the following endpoints: all-cause and cardiovascular mortality, myocardial infarction, and stroke. Four studies with a total of 30,791 of patients met the inclusion criteria. The combination CCB/thiazide (-like) diuretic was associated with a significant risk reduction for myocardial infarction (risk ratio [RR], 0.83; 95% confidence interval [CI], 0.73-0.95) and stroke (RR, 0.77; CI, 0.64-0.92) compared with other combinations, whereas it was similarly effective compared with other combinations in reducing the risk of all-cause (RR, 0.89; CI, 0.75-1.06) and cardiovascular (RR, 0.89; CI 0.71-1.10) mortality. Elderly patients with isolated systolic hypertension may particularly benefit from such a combination, since both drug classes have been shown to confer cerebrovascular protection.
AB - Although recent guidelines recommend the combination of calcium channel blockers (CCBs) and thiazide (-like) diuretics, this combination is not widely used in clinical practice. The aim of this meta-analysis was to assess the efficacy and safety of this combination regarding the following endpoints: all-cause and cardiovascular mortality, myocardial infarction, and stroke. Four studies with a total of 30,791 of patients met the inclusion criteria. The combination CCB/thiazide (-like) diuretic was associated with a significant risk reduction for myocardial infarction (risk ratio [RR], 0.83; 95% confidence interval [CI], 0.73-0.95) and stroke (RR, 0.77; CI, 0.64-0.92) compared with other combinations, whereas it was similarly effective compared with other combinations in reducing the risk of all-cause (RR, 0.89; CI, 0.75-1.06) and cardiovascular (RR, 0.89; CI 0.71-1.10) mortality. Elderly patients with isolated systolic hypertension may particularly benefit from such a combination, since both drug classes have been shown to confer cerebrovascular protection.
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U2 - 10.1111/jch.12462
DO - 10.1111/jch.12462
M3 - Article
C2 - 25556777
AN - SCOPUS:84924706041
SN - 1524-6175
VL - 17
SP - 193
EP - 199
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
IS - 3
ER -
