Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention

John A. Ambrose, Ramy Doss, Jean Pierre M. Geagea, Marian C. Hawkey, Srinivas Duvuri, Kenneth Giedd, Alvaro Dominguez, John Coppola, Tien H. Nguyen, Venugopal Palla, Rajat S. Barua, Dhanonjoy C. Saha

Research output: Contribution to journalArticle

6 Scopus citations


The antithrombin generating effects of tirofiban were compared with abciximab in patients who underwent intervention and received intravenous heparin based on their weight. A standardized protocol serially measured the ACT, F1.2, and platelet receptor occupancy. Both GP IIb/IIIa agents had similar effects on reducing thrombin generation, and there were no significant differences between the groups at any measurement interval.

Original languageEnglish (US)
Pages (from-to)1231-1233
Number of pages3
JournalAmerican Journal of Cardiology
Issue number10
Publication statusPublished - May 15 2001
Externally publishedYes


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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