Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention

John A. Ambrose, Ramy Doss, Jean Pierre M Geagea, Marian C. Hawkey, Srinivas Duvuri, Kenneth Giedd, Alvaro Dominguez, John Coppola, Tien H. Nguyen, Venugopal Palla, Rajat S. Barua, Dhanonjoy C. Saha

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The antithrombin generating effects of tirofiban were compared with abciximab in patients who underwent intervention and received intravenous heparin based on their weight. A standardized protocol serially measured the ACT, F1.2, and platelet receptor occupancy. Both GP IIb/IIIa agents had similar effects on reducing thrombin generation, and there were no significant differences between the groups at any measurement interval.

Original languageEnglish (US)
Pages (from-to)1231-1233
Number of pages3
JournalAmerican Journal of Cardiology
Volume87
Issue number10
DOIs
StatePublished - May 15 2001
Externally publishedYes

Fingerprint

tirofiban
Platelet Membrane Glycoprotein IIb
Integrin beta3
Platelet Glycoprotein GPIIb-IIIa Complex
Antithrombins
Thrombin
Heparin
Blood Platelets
Weights and Measures
abciximab

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention. / Ambrose, John A.; Doss, Ramy; Geagea, Jean Pierre M; Hawkey, Marian C.; Duvuri, Srinivas; Giedd, Kenneth; Dominguez, Alvaro; Coppola, John; Nguyen, Tien H.; Palla, Venugopal; Barua, Rajat S.; Saha, Dhanonjoy C.

In: American Journal of Cardiology, Vol. 87, No. 10, 15.05.2001, p. 1231-1233.

Research output: Contribution to journalArticle

Ambrose, JA, Doss, R, Geagea, JPM, Hawkey, MC, Duvuri, S, Giedd, K, Dominguez, A, Coppola, J, Nguyen, TH, Palla, V, Barua, RS & Saha, DC 2001, 'Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention', American Journal of Cardiology, vol. 87, no. 10, pp. 1231-1233. https://doi.org/10.1016/S0002-9149(01)01506-5
Ambrose, John A. ; Doss, Ramy ; Geagea, Jean Pierre M ; Hawkey, Marian C. ; Duvuri, Srinivas ; Giedd, Kenneth ; Dominguez, Alvaro ; Coppola, John ; Nguyen, Tien H. ; Palla, Venugopal ; Barua, Rajat S. ; Saha, Dhanonjoy C. / Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention. In: American Journal of Cardiology. 2001 ; Vol. 87, No. 10. pp. 1231-1233.
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AU - Nguyen, Tien H.

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