Effects of m-chlorophenylpiperazine in normal subjects: a dose-response study

R. S. Kahn, S. Wetzler, G. M. Asnis, M. A. Kling, R. F. Suckow, H. M. van Praag

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m-Chlorophenylpiperazine (MCPP), a direct 5HT receptor agonist, was administered orally to 20 normal subjects in two doses (0.25 and 0.5 mg/kg) in a placebo-controlled design. Behavioral responses; ACTH, cortisol, prolactin and MCPP blood level; temperature and pulse rate were measured over a 210-min period after administration of tablets. Non-linear dose-response relationships between MCPP and ACTH, cortisol and prolactin response were found. On the higher dose, a significant increase in the number of physical symptoms was also noted and three subjects (15%) had a panic attack, while one subject (5%) had a panic attack on the lower dose. No effects on other behavioral variables, pulse rate and temperature were found using either dose. These findings attest to the usefulness of MCPP as a challenge agent to assess 5HT receptor hypersensitivity when given at a low oral dose (i.e. around 0.25 mg/kg), and to assess 5HT receptor hyposensitivity when given at higher oral doses (i.e. around 0.5 mg/kg).

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
Issue number3
StatePublished - Mar 1 1990


  • Dose-response
  • Normal subjects
  • Serotonin
  • m-Chlorophenylpiperazine

ASJC Scopus subject areas

  • Pharmacology

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    Kahn, R. S., Wetzler, S., Asnis, G. M., Kling, M. A., Suckow, R. F., & van Praag, H. M. (1990). Effects of m-chlorophenylpiperazine in normal subjects: a dose-response study. Psychopharmacology, 100(3), 339-344. https://doi.org/10.1007/BF02244603