Effects of m-chlorophenylpiperazine in normal subjects: a dose-response study

R. S. Kahn, Scott Wetzler, G. M. Asnis, M. A. Kling, R. F. Suckow, H. M. van Praag

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

m-Chlorophenylpiperazine (MCPP), a direct 5HT receptor agonist, was administered orally to 20 normal subjects in two doses (0.25 and 0.5 mg/kg) in a placebo-controlled design. Behavioral responses; ACTH, cortisol, prolactin and MCPP blood level; temperature and pulse rate were measured over a 210-min period after administration of tablets. Non-linear dose-response relationships between MCPP and ACTH, cortisol and prolactin response were found. On the higher dose, a significant increase in the number of physical symptoms was also noted and three subjects (15%) had a panic attack, while one subject (5%) had a panic attack on the lower dose. No effects on other behavioral variables, pulse rate and temperature were found using either dose. These findings attest to the usefulness of MCPP as a challenge agent to assess 5HT receptor hypersensitivity when given at a low oral dose (i.e. around 0.25 mg/kg), and to assess 5HT receptor hyposensitivity when given at higher oral doses (i.e. around 0.5 mg/kg).

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
JournalPsychopharmacology
Volume100
Issue number3
DOIs
StatePublished - Mar 1990

Fingerprint

Panic Disorder
Prolactin
Adrenocorticotropic Hormone
Hydrocortisone
Heart Rate
Temperature
Tablets
Hypersensitivity
Placebos
1-(3-chlorophenyl)piperazine

Keywords

  • Dose-response
  • m-Chlorophenylpiperazine
  • Normal subjects
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Kahn, R. S., Wetzler, S., Asnis, G. M., Kling, M. A., Suckow, R. F., & van Praag, H. M. (1990). Effects of m-chlorophenylpiperazine in normal subjects: a dose-response study. Psychopharmacology, 100(3), 339-344. https://doi.org/10.1007/BF02244603

Effects of m-chlorophenylpiperazine in normal subjects : a dose-response study. / Kahn, R. S.; Wetzler, Scott; Asnis, G. M.; Kling, M. A.; Suckow, R. F.; van Praag, H. M.

In: Psychopharmacology, Vol. 100, No. 3, 03.1990, p. 339-344.

Research output: Contribution to journalArticle

Kahn, RS, Wetzler, S, Asnis, GM, Kling, MA, Suckow, RF & van Praag, HM 1990, 'Effects of m-chlorophenylpiperazine in normal subjects: a dose-response study', Psychopharmacology, vol. 100, no. 3, pp. 339-344. https://doi.org/10.1007/BF02244603
Kahn, R. S. ; Wetzler, Scott ; Asnis, G. M. ; Kling, M. A. ; Suckow, R. F. ; van Praag, H. M. / Effects of m-chlorophenylpiperazine in normal subjects : a dose-response study. In: Psychopharmacology. 1990 ; Vol. 100, No. 3. pp. 339-344.
@article{e7e9247b3e734a49a7a168474be7b9d7,
title = "Effects of m-chlorophenylpiperazine in normal subjects: a dose-response study",
abstract = "m-Chlorophenylpiperazine (MCPP), a direct 5HT receptor agonist, was administered orally to 20 normal subjects in two doses (0.25 and 0.5 mg/kg) in a placebo-controlled design. Behavioral responses; ACTH, cortisol, prolactin and MCPP blood level; temperature and pulse rate were measured over a 210-min period after administration of tablets. Non-linear dose-response relationships between MCPP and ACTH, cortisol and prolactin response were found. On the higher dose, a significant increase in the number of physical symptoms was also noted and three subjects (15{\%}) had a panic attack, while one subject (5{\%}) had a panic attack on the lower dose. No effects on other behavioral variables, pulse rate and temperature were found using either dose. These findings attest to the usefulness of MCPP as a challenge agent to assess 5HT receptor hypersensitivity when given at a low oral dose (i.e. around 0.25 mg/kg), and to assess 5HT receptor hyposensitivity when given at higher oral doses (i.e. around 0.5 mg/kg).",
keywords = "Dose-response, m-Chlorophenylpiperazine, Normal subjects, Serotonin",
author = "Kahn, {R. S.} and Scott Wetzler and Asnis, {G. M.} and Kling, {M. A.} and Suckow, {R. F.} and {van Praag}, {H. M.}",
year = "1990",
month = "3",
doi = "10.1007/BF02244603",
language = "English (US)",
volume = "100",
pages = "339--344",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Effects of m-chlorophenylpiperazine in normal subjects

T2 - a dose-response study

AU - Kahn, R. S.

AU - Wetzler, Scott

AU - Asnis, G. M.

AU - Kling, M. A.

AU - Suckow, R. F.

AU - van Praag, H. M.

PY - 1990/3

Y1 - 1990/3

N2 - m-Chlorophenylpiperazine (MCPP), a direct 5HT receptor agonist, was administered orally to 20 normal subjects in two doses (0.25 and 0.5 mg/kg) in a placebo-controlled design. Behavioral responses; ACTH, cortisol, prolactin and MCPP blood level; temperature and pulse rate were measured over a 210-min period after administration of tablets. Non-linear dose-response relationships between MCPP and ACTH, cortisol and prolactin response were found. On the higher dose, a significant increase in the number of physical symptoms was also noted and three subjects (15%) had a panic attack, while one subject (5%) had a panic attack on the lower dose. No effects on other behavioral variables, pulse rate and temperature were found using either dose. These findings attest to the usefulness of MCPP as a challenge agent to assess 5HT receptor hypersensitivity when given at a low oral dose (i.e. around 0.25 mg/kg), and to assess 5HT receptor hyposensitivity when given at higher oral doses (i.e. around 0.5 mg/kg).

AB - m-Chlorophenylpiperazine (MCPP), a direct 5HT receptor agonist, was administered orally to 20 normal subjects in two doses (0.25 and 0.5 mg/kg) in a placebo-controlled design. Behavioral responses; ACTH, cortisol, prolactin and MCPP blood level; temperature and pulse rate were measured over a 210-min period after administration of tablets. Non-linear dose-response relationships between MCPP and ACTH, cortisol and prolactin response were found. On the higher dose, a significant increase in the number of physical symptoms was also noted and three subjects (15%) had a panic attack, while one subject (5%) had a panic attack on the lower dose. No effects on other behavioral variables, pulse rate and temperature were found using either dose. These findings attest to the usefulness of MCPP as a challenge agent to assess 5HT receptor hypersensitivity when given at a low oral dose (i.e. around 0.25 mg/kg), and to assess 5HT receptor hyposensitivity when given at higher oral doses (i.e. around 0.5 mg/kg).

KW - Dose-response

KW - m-Chlorophenylpiperazine

KW - Normal subjects

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0025191278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025191278&partnerID=8YFLogxK

U2 - 10.1007/BF02244603

DO - 10.1007/BF02244603

M3 - Article

C2 - 2156278

AN - SCOPUS:0025191278

VL - 100

SP - 339

EP - 344

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 3

ER -