Abstract
Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50±1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28±12% (P<.05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain.
Original language | English (US) |
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Pages (from-to) | 693-697 |
Number of pages | 5 |
Journal | Magnetic Resonance Imaging |
Volume | 24 |
Issue number | 6 |
DOIs | |
State | Published - Jul 2006 |
Externally published | Yes |
Keywords
- BOLD effect
- Functional MRI
- Hypoglycemia
- Visual cortex
ASJC Scopus subject areas
- Biophysics
- Biomedical Engineering
- Radiology Nuclear Medicine and imaging