Effects of hypoglycemia on human brain activation measured with fMRI

Adam W. Anderson, Rubina A. Heptulla, Naomi Driesen, Daniel Flanagan, Philip A. Goldberg, Timothy W. Jones, Fran Rife, Hedy Sarofin, William Tamborlane, Robert Sherwin, John C. Gore

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50±1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28±12% (P<.05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain.

Original languageEnglish (US)
Pages (from-to)693-697
Number of pages5
JournalMagnetic Resonance Imaging
Volume24
Issue number6
DOIs
StatePublished - Jul 2006
Externally publishedYes

Fingerprint

hypoglycemia
Hypoglycemia
blood
brain
magnetic resonance
Brain
Blood
Chemical activation
Magnetic Resonance Imaging
activation
glucose
sensory stimulation
Glucose
visual stimuli
Oxygen
Photic Stimulation
clamps
Glucose Clamp Technique
Clamping devices
oxygen

Keywords

  • BOLD effect
  • Functional MRI
  • Hypoglycemia
  • Visual cortex

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Anderson, A. W., Heptulla, R. A., Driesen, N., Flanagan, D., Goldberg, P. A., Jones, T. W., ... Gore, J. C. (2006). Effects of hypoglycemia on human brain activation measured with fMRI. Magnetic Resonance Imaging, 24(6), 693-697. https://doi.org/10.1016/j.mri.2006.03.013

Effects of hypoglycemia on human brain activation measured with fMRI. / Anderson, Adam W.; Heptulla, Rubina A.; Driesen, Naomi; Flanagan, Daniel; Goldberg, Philip A.; Jones, Timothy W.; Rife, Fran; Sarofin, Hedy; Tamborlane, William; Sherwin, Robert; Gore, John C.

In: Magnetic Resonance Imaging, Vol. 24, No. 6, 07.2006, p. 693-697.

Research output: Contribution to journalArticle

Anderson, AW, Heptulla, RA, Driesen, N, Flanagan, D, Goldberg, PA, Jones, TW, Rife, F, Sarofin, H, Tamborlane, W, Sherwin, R & Gore, JC 2006, 'Effects of hypoglycemia on human brain activation measured with fMRI', Magnetic Resonance Imaging, vol. 24, no. 6, pp. 693-697. https://doi.org/10.1016/j.mri.2006.03.013
Anderson AW, Heptulla RA, Driesen N, Flanagan D, Goldberg PA, Jones TW et al. Effects of hypoglycemia on human brain activation measured with fMRI. Magnetic Resonance Imaging. 2006 Jul;24(6):693-697. https://doi.org/10.1016/j.mri.2006.03.013
Anderson, Adam W. ; Heptulla, Rubina A. ; Driesen, Naomi ; Flanagan, Daniel ; Goldberg, Philip A. ; Jones, Timothy W. ; Rife, Fran ; Sarofin, Hedy ; Tamborlane, William ; Sherwin, Robert ; Gore, John C. / Effects of hypoglycemia on human brain activation measured with fMRI. In: Magnetic Resonance Imaging. 2006 ; Vol. 24, No. 6. pp. 693-697.
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