Effects of hypoglycemia on human brain activation measured with fMRI

Adam W. Anderson, Rubina A. Heptulla, Naomi Driesen, Daniel Flanagan, Philip A. Goldberg, Timothy W. Jones, Fran Rife, Hedy Sarofin, William Tamborlane, Robert Sherwin, John C. Gore

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory stimulation on brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast, which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50±1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects: the fractional signal change was reduced by 28±12% (P<.05). These changes were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain.

Original languageEnglish (US)
Pages (from-to)693-697
Number of pages5
JournalMagnetic Resonance Imaging
Issue number6
StatePublished - Jul 2006
Externally publishedYes


  • BOLD effect
  • Functional MRI
  • Hypoglycemia
  • Visual cortex

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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