Effects of exercise and poor indoor air quality on learning, memory and blood IGF-1 in adolescent mice

Nazan Uysal, M. Kiray, A. R. Sisman, B. Baykara, I. Aksu, A. Dayi, C. Gencoglu, M. Evren, Erkan Buyuk, F. Cetin, O. Acikgoz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

It is known that regular aerobic exercise enhances cognitive functions and increases blood insulin-like growth factor 1 (IGF-1) levels. People living in urban areas spend most of their time indoors and indoor air quality can affect health. We investigated the effects of aerobic exercise in poor and good air quality environments on hippocampus and prefrontal cortex (PFC) neurons, anxiety, and spatial learning and memory in adolescent mice. Poor air quality impaired spatial learning and memory; exercise did not affect learning or memory impairment. Exercise in a good air quality environment improved spatial learning and memory. Poor air quality increased apoptosis in the hippocampus and PFC. Both exercised and sedentary groups living in a poor air quality environment had lower serum IGF-1 levels than those living in a good air quality environment. Living in a poor air quality environment has negative effects on the hippocampus, PFC and blood IGF-1 levels in adolescent mice, but exercise did not alter the negative effects of poor air quality.

Original languageEnglish (US)
Pages (from-to)126-135
Number of pages10
JournalBiotechnic and Histochemistry
Volume89
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

Indoor Air Pollution
Somatomedins
Air
Learning
Prefrontal Cortex
Hippocampus
Exercise
Cognition
Anxiety
Apoptosis
Neurons
Health

Keywords

  • Adolescent
  • Air quality
  • Carbon dioxide
  • Exercise
  • Hippocampus
  • IGF-1
  • Learning
  • Memory
  • Prefrontal cortex

ASJC Scopus subject areas

  • Histology
  • Medical Laboratory Technology

Cite this

Effects of exercise and poor indoor air quality on learning, memory and blood IGF-1 in adolescent mice. / Uysal, Nazan; Kiray, M.; Sisman, A. R.; Baykara, B.; Aksu, I.; Dayi, A.; Gencoglu, C.; Evren, M.; Buyuk, Erkan; Cetin, F.; Acikgoz, O.

In: Biotechnic and Histochemistry, Vol. 89, No. 2, 02.2014, p. 126-135.

Research output: Contribution to journalArticle

Uysal, N, Kiray, M, Sisman, AR, Baykara, B, Aksu, I, Dayi, A, Gencoglu, C, Evren, M, Buyuk, E, Cetin, F & Acikgoz, O 2014, 'Effects of exercise and poor indoor air quality on learning, memory and blood IGF-1 in adolescent mice', Biotechnic and Histochemistry, vol. 89, no. 2, pp. 126-135. https://doi.org/10.3109/10520295.2013.825318
Uysal, Nazan ; Kiray, M. ; Sisman, A. R. ; Baykara, B. ; Aksu, I. ; Dayi, A. ; Gencoglu, C. ; Evren, M. ; Buyuk, Erkan ; Cetin, F. ; Acikgoz, O. / Effects of exercise and poor indoor air quality on learning, memory and blood IGF-1 in adolescent mice. In: Biotechnic and Histochemistry. 2014 ; Vol. 89, No. 2. pp. 126-135.
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