Effects of anticipated neonatal surgical intervention on maternal milk cytokine production

Rebecca M. Rentea, Amy J. Wagner, David M. Gourlay, Melissa Christensen, Jennifer L. Liedel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background Maternal stress on neonatal outcomes of infants admitted to the NICU is incompletely understood. We previously demonstrated breast milk derived cytokines remain biologically active in the neonatal intestine. We hypothesized that the need for neonatal surgical intervention would be stimulus leading to maternal cytokine production thus affecting neonatal outcome. Methods Discarded expressed breast milk (EBM) in the first 3 weeks following delivery was analyzed for IL-23 and IL-10 by ELISA. Variables analyzed included: the need for a pediatric surgical procedure, the need for cardiac surgical procedure, no surgical interventions, and survival. All values are expressed as mean ± SEM. Statistical analysis utilized Kruskal and Mann–Whitney test. Results EBM from mothers whose infants required any surgical procedure (n = 19) revealed significant elevation in IL-10 but not IL-23 compared to nonsurgical EBM (n = 18). Subdivided by procedure type, there was no difference between those undergoing a cardiac (n = 9) versus pediatric surgical (n = 10) procedure in both IL-10 and IL-23. Mothers whose infants requiring surgical intervention or whose infants did not survive in the first 3 weeks of life had elevation of IL-10. Conclusion Results suggest maternal stress impacts the cytokine profile of breast milk. Level of evidence Level III.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalJournal of Pediatric Surgery
Volume52
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Human Milk
Milk
Interleukin-23
Interleukin-10
Mothers
Cytokines
Cardiac Surgical Procedures
Pediatrics
Intestines
Enzyme-Linked Immunosorbent Assay

Keywords

  • Cardiac surgery
  • Cytokine
  • Il-10
  • Il-23
  • Inflammation
  • Necrotizing enterocolitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Effects of anticipated neonatal surgical intervention on maternal milk cytokine production. / Rentea, Rebecca M.; Wagner, Amy J.; Gourlay, David M.; Christensen, Melissa; Liedel, Jennifer L.

In: Journal of Pediatric Surgery, Vol. 52, No. 1, 01.01.2017, p. 45-49.

Research output: Contribution to journalArticle

Rentea, Rebecca M. ; Wagner, Amy J. ; Gourlay, David M. ; Christensen, Melissa ; Liedel, Jennifer L. / Effects of anticipated neonatal surgical intervention on maternal milk cytokine production. In: Journal of Pediatric Surgery. 2017 ; Vol. 52, No. 1. pp. 45-49.
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