Abstract
1,25 Dihydroxyvitamin D3 (1,25(OH)2D3) (2.0 μg) was given intramuscularly to 6 healthy adult males. Twenty-four circadian patterns of blood-ionized calcium (Ca2+), serum phosphate (Pi), and total calcium (CaT) were assessed pre- and posthormone administration. Correlations of mean mineral rhythms with normative models were significant for each mineral pattern on both study days. Mean Ca2+ and CaT rhythms became weakly correlated after hormone treatment (r=.39). A small but statistically significant increment in the 24 h grand mean Ca2+ concentration was observed on the treatment day compared with the baseline day. However, this increment is less than the year-to-year variability in the grand mean mineral concentrations derived from the same subjects studied under baseline conditions previously. These data indicate that acute parenteral administration of near-physiological (2.0 μg) doses of 1,25(OH)2D3 appears to have no major effect on circadian mineral pattern shape or mean mineral concentrations.
Original language | English (US) |
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Pages (from-to) | 351-356 |
Number of pages | 6 |
Journal | Calcified Tissue International |
Volume | 37 |
Issue number | 4 |
DOIs | |
State | Published - Jul 1985 |
Keywords
- 1,25(OH)D
- Blood-ionized calcium
- Circadian mineral patterns
- Serum phosphate
- Total calcium
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Orthopedics and Sports Medicine
- Endocrinology