Effects of 1,25 dihydroxyvitamin D3 administration on circadian mineral rhythms in humans

Morri E. Markowitz, John F. Rosen, Mark Mizruchi

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Abstract

1,25 Dihydroxyvitamin D3 (1,25(OH)2D3) (2.0 μg) was given intramuscularly to 6 healthy adult males. Twenty-four circadian patterns of blood-ionized calcium (Ca2+), serum phosphate (Pi), and total calcium (CaT) were assessed pre- and posthormone administration. Correlations of mean mineral rhythms with normative models were significant for each mineral pattern on both study days. Mean Ca2+ and CaT rhythms became weakly correlated after hormone treatment (r=.39). A small but statistically significant increment in the 24 h grand mean Ca2+ concentration was observed on the treatment day compared with the baseline day. However, this increment is less than the year-to-year variability in the grand mean mineral concentrations derived from the same subjects studied under baseline conditions previously. These data indicate that acute parenteral administration of near-physiological (2.0 μg) doses of 1,25(OH)2D3 appears to have no major effect on circadian mineral pattern shape or mean mineral concentrations.

Original languageEnglish (US)
Pages (from-to)351-356
Number of pages6
JournalCalcified Tissue International
Volume37
Issue number4
DOIs
Publication statusPublished - Jul 1 1985

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