Effective surface charge density determines the electrostatic attraction between nanoparticles and cells

Gaoxing Su; Hongyu Zhou; Qingxin Mu; Yi Zhang; Liwen Li; Peifu Jiao; Guibin Jiang; Bing Yan

doi:10.1021/jp211041m

Effective surface charge density determines the electrostatic attraction between nanoparticles and cells

Gaoxing Su, Hongyu Zhou, Qingxin Mu, Yi Zhang, Liwen Li, Peifu Jiao, Guibin Jiang, Bing Yan

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

We examine the origin of the electrostatic attraction between nanoparticle (NP) and cells by synthesizing a NP array with a continuous change in surface charge density (SCD). This attraction does not show a linear and continuous change, but a sharp increase as the positive SCD increases. The results of zeta potential measurements of the naked and protein bound NPs reveal that excessive charges on surface ligands are partially shielded, and the noncovalent protein bindings do not influence NP-cell electrostatic interactions. The effective SCD on the outmost layer of NPs determined the electrostatic attraction between NPs and cells

Original language	English (US)
Pages (from-to)	4993-4998
Number of pages	6
Journal	Journal of Physical Chemistry C
Volume	116
Issue number	8
DOIs	https://doi.org/10.1021/jp211041m
State	Published - Mar 1 2012
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Energy
Physical and Theoretical Chemistry
Surfaces, Coatings and Films

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10.1021/jp211041m

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AU - Su, Gaoxing

AU - Zhou, Hongyu

AU - Mu, Qingxin

AU - Zhang, Yi

AU - Li, Liwen

AU - Jiao, Peifu

AU - Jiang, Guibin

AU - Yan, Bing

PY - 2012/3/1

Y1 - 2012/3/1

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AB - We examine the origin of the electrostatic attraction between nanoparticle (NP) and cells by synthesizing a NP array with a continuous change in surface charge density (SCD). This attraction does not show a linear and continuous change, but a sharp increase as the positive SCD increases. The results of zeta potential measurements of the naked and protein bound NPs reveal that excessive charges on surface ligands are partially shielded, and the noncovalent protein bindings do not influence NP-cell electrostatic interactions. The effective SCD on the outmost layer of NPs determined the electrostatic attraction between NPs and cells

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Effective surface charge density determines the electrostatic attraction between nanoparticles and cells

Abstract

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