Effect of modest changes in BMI on cardiovascular disease risk markers in severely obese, minority adolescents

Unab I. Khan, Jessica Rieder, Hillel W. Cohen, Susan M. Coupey, Rachel P. Wildman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: African American and Hispanic adolescents have disproportionately higher rates of obesity compared to white adolescents. In adults, modest weight loss of five percent improves CVD risk marker levels. Less is known about the effects of modest changes in BMI on CVD risk markers in adolescents, particularly newer markers such as C reactive protein (CRP), lipoprotein (a) and homocysteine. Objective: To examine the effect of modest BMI change on CVD risk marker levels in a group of severely obese, African American and Hispanic adolescents. Study design: A six-month longitudinal analysis. Subjects: Eighty-three African American and Hispanic adolescents were recruited (mean age±sd: 15.1±2.0 years); 50 (60%) were reevaluated at 6±2 months. Results: At baseline, mean BMI was 42.3±7.8 kg/m 2. BMI directly correlated with CRP (p = < 0.001); homocysteine (p = 0.02); insulin (p = 0.05); and systolic and diastolic blood pressures (both p = <0.001). BMI remained significantly associated with CRP and insulin after adjusting for age, sex and ethnicity (p = 0.001). At six-month follow up, there was a significant p for trend between the three groups of BMI change (those with a ≥5% BMI decrease, those who maintained BMI within 5% and those with ≥5% BMI increase) and CRP (p = 0.05) and insulin (p = 0.04). Conclusions: A modest decrease in BMI is associated with improvement in CRP and insulin levels. Obese adolescents should be encouraged to continue with modest weight loss goals as they result in improvement in cardiovascular disease risk markers.

Original languageEnglish (US)
JournalObesity Research and Clinical Practice
Volume4
Issue number3
DOIs
StatePublished - Jul 2010

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Cardiovascular Diseases
C-Reactive Protein
Hispanic Americans
African Americans
Insulin
Homocysteine
Weight Loss
Blood Pressure
Lipoprotein(a)
Obesity

Keywords

  • Adolescent obesity
  • C reactive protein
  • Cardiovascular disease risk markers

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Effect of modest changes in BMI on cardiovascular disease risk markers in severely obese, minority adolescents. / Khan, Unab I.; Rieder, Jessica; Cohen, Hillel W.; Coupey, Susan M.; Wildman, Rachel P.

In: Obesity Research and Clinical Practice, Vol. 4, No. 3, 07.2010.

Research output: Contribution to journalArticle

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abstract = "Background: African American and Hispanic adolescents have disproportionately higher rates of obesity compared to white adolescents. In adults, modest weight loss of five percent improves CVD risk marker levels. Less is known about the effects of modest changes in BMI on CVD risk markers in adolescents, particularly newer markers such as C reactive protein (CRP), lipoprotein (a) and homocysteine. Objective: To examine the effect of modest BMI change on CVD risk marker levels in a group of severely obese, African American and Hispanic adolescents. Study design: A six-month longitudinal analysis. Subjects: Eighty-three African American and Hispanic adolescents were recruited (mean age±sd: 15.1±2.0 years); 50 (60{\%}) were reevaluated at 6±2 months. Results: At baseline, mean BMI was 42.3±7.8 kg/m 2. BMI directly correlated with CRP (p = < 0.001); homocysteine (p = 0.02); insulin (p = 0.05); and systolic and diastolic blood pressures (both p = <0.001). BMI remained significantly associated with CRP and insulin after adjusting for age, sex and ethnicity (p = 0.001). At six-month follow up, there was a significant p for trend between the three groups of BMI change (those with a ≥5{\%} BMI decrease, those who maintained BMI within 5{\%} and those with ≥5{\%} BMI increase) and CRP (p = 0.05) and insulin (p = 0.04). Conclusions: A modest decrease in BMI is associated with improvement in CRP and insulin levels. Obese adolescents should be encouraged to continue with modest weight loss goals as they result in improvement in cardiovascular disease risk markers.",
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AU - Wildman, Rachel P.

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