Effect of hypoxia on cellular interaction in the myocardium

Yu Yu Bredikis; F. F. Bukauskas; K. S. Mutskus

doi:10.1007/BF00789857

Effect of hypoxia on cellular interaction in the myocardium

Yu Yu Bredikis, F. F. Bukauskas, K. S. Mutskus

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Passive electrical properties in the papillary muscle of the rabbit heart were investigated under (control) and hypoxic conditions. The input resistance and the length constant of electronic decay were measured. With the use of a two-dimensional model of the anisotropic syncytium and the results of measurement of the length constant and input resistance it was shown that the resistance of the electrogenic membrane is reduced by 1.4 times after 10 min of hypoxia, whereas the resistance of the intracellular medium of the syncytium in the longitudinal (ρ_x) and transverse (ρ_y) directions of the fibers is increased by 1.39 and 1.3 times respectively. The increases ρ_x and ρ_y are due to an increase in resistance of the contacting membranes. Disturbance of cellular interaction during hypoxia is important to the understanding of the mechanism of the cardiac arrhythmias arising in ischemia of the heart and myocardial infarction.

Original language	English (US)
Pages (from-to)	1016-1019
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	82
Issue number	1
DOIs	https://doi.org/10.1007/BF00789857
State	Published - Jul 1976
Externally published	Yes

Keywords

cellular interaction in the myocardium
hypoxia
input resistance
length constant

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/BF00789857

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title = "Effect of hypoxia on cellular interaction in the myocardium",

abstract = "Passive electrical properties in the papillary muscle of the rabbit heart were investigated under (control) and hypoxic conditions. The input resistance and the length constant of electronic decay were measured. With the use of a two-dimensional model of the anisotropic syncytium and the results of measurement of the length constant and input resistance it was shown that the resistance of the electrogenic membrane is reduced by 1.4 times after 10 min of hypoxia, whereas the resistance of the intracellular medium of the syncytium in the longitudinal (ρx) and transverse (ρy) directions of the fibers is increased by 1.39 and 1.3 times respectively. The increases ρx and ρy are due to an increase in resistance of the contacting membranes. Disturbance of cellular interaction during hypoxia is important to the understanding of the mechanism of the cardiac arrhythmias arising in ischemia of the heart and myocardial infarction.",

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T1 - Effect of hypoxia on cellular interaction in the myocardium

AU - Bredikis, Yu Yu

AU - Bukauskas, F. F.

AU - Mutskus, K. S.

PY - 1976/7

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N2 - Passive electrical properties in the papillary muscle of the rabbit heart were investigated under (control) and hypoxic conditions. The input resistance and the length constant of electronic decay were measured. With the use of a two-dimensional model of the anisotropic syncytium and the results of measurement of the length constant and input resistance it was shown that the resistance of the electrogenic membrane is reduced by 1.4 times after 10 min of hypoxia, whereas the resistance of the intracellular medium of the syncytium in the longitudinal (ρx) and transverse (ρy) directions of the fibers is increased by 1.39 and 1.3 times respectively. The increases ρx and ρy are due to an increase in resistance of the contacting membranes. Disturbance of cellular interaction during hypoxia is important to the understanding of the mechanism of the cardiac arrhythmias arising in ischemia of the heart and myocardial infarction.

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Effect of hypoxia on cellular interaction in the myocardium

Abstract

Keywords

ASJC Scopus subject areas

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