Passive electrical properties in the papillary muscle of the rabbit heart were investigated under (control) and hypoxic conditions. The input resistance and the length constant of electronic decay were measured. With the use of a two-dimensional model of the anisotropic syncytium and the results of measurement of the length constant and input resistance it was shown that the resistance of the electrogenic membrane is reduced by 1.4 times after 10 min of hypoxia, whereas the resistance of the intracellular medium of the syncytium in the longitudinal (ρx) and transverse (ρy) directions of the fibers is increased by 1.39 and 1.3 times respectively. The increases ρx and ρy are due to an increase in resistance of the contacting membranes. Disturbance of cellular interaction during hypoxia is important to the understanding of the mechanism of the cardiac arrhythmias arising in ischemia of the heart and myocardial infarction.
- cellular interaction in the myocardium
- input resistance
- length constant
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)