Effect of 17 β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats

Inmaculada Tasset, José Peña, Ignacio Jimena, Montserrat Feijóo, María del Carmern Muñoz, Pedro Montilla, Isaac Túnez

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The present study evaluated 17β-estradiol (17βE2) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17βE2 (14 days). Our results reveled that 17βE2 has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties.

Original languageEnglish (US)
Pages (from-to)441-449
Number of pages9
JournalNeuropsychiatric Disease and Treatment
Volume4
Issue number2
StatePublished - May 27 2008
Externally publishedYes

Keywords

  • 17 β-estradiol
  • Behavioral
  • Depression
  • Oxidative stress

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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