Educational case

Endocrine neoplasm: Medullary thyroid carcinoma

Sheila Segura, Gloria Ramos-Rivera, Mark J. Suhrland

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Medullary thyroid cancer is a rare neuroendocrine tumor that arises the neural crest-derived parafollicular C cells and accounts for approximately 5% to 10% of thyroid cancers worldwide. These tumor can occur sporadically or as part of hereditary tumor syndromes, such as multiple endocrine neoplasia 2 and familial medullary thyroid cancer. The most common clinical presentation is a solitary thyroid nodule. The genetic defect in these disorders involves the RET proto-oncogene which is important for diagnosis of medullary thyroid cancer (including screening for hereditary medullary thyroid cancer) and for treatment guidance.This review summarizes the molecular basis and clinicopathologic features of medullary thyroid carcinoma.

Original languageEnglish (US)
JournalAcademic Pathology
Volume5
DOIs
StatePublished - Jan 1 2018

Fingerprint

Neoplasms
Multiple Endocrine Neoplasia
Thyroid Nodule
Neuroendocrine Tumors
Proto-Oncogenes
Neural Crest
Early Detection of Cancer
Thyroid Neoplasms
Medullary Thyroid cancer
Therapeutics
Familial medullary thyroid carcinoma

Keywords

  • Clinical features
  • Cytologic diagnosis
  • Endocrine neoplasms
  • Medullary thyroid carcinoma
  • Molecular basis
  • Organ system pathology
  • Pathologic features
  • Pathology competencies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Educational case : Endocrine neoplasm: Medullary thyroid carcinoma. / Segura, Sheila; Ramos-Rivera, Gloria; Suhrland, Mark J.

In: Academic Pathology, Vol. 5, 01.01.2018.

Research output: Contribution to journalArticle

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