Early response to desipramine among women with bulimia nervosa

B. Timothy Walsh; Robyn Sysko; Michael K. Parides

doi:10.1002/eat.20209

Early response to desipramine among women with bulimia nervosa

B. Timothy Walsh, Robyn Sysko, Michael K. Parides

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Objective: Numerous trials have demonstrated the efficacy of antidepressant medications for the treatment of bulimia nervosa (BN). The current study examined whether early response to medication predicted response to medication at the end of a controlled trial. Method: Data from two previously published studies of desipramine (DMI) were used. Seventy-seven patients with BN were included in the analysis. Receiver operating characteristic (ROC) curves were constructed to examine the relation between the percentage reduction in symptoms at each week and failure to respond to antidepressant medication at the end of the trial. Results: Eventual nonresponders to DMI could be reliably identified in the first 2 weeks of treatment. Discussion: The current study provides preliminary evidence that patients with BN who will not respond to antidepressant medication can be identified in the first 2 weeks of treatment.

Original language	English (US)
Pages (from-to)	72-75
Number of pages	4
Journal	International Journal of Eating Disorders
Volume	39
Issue number	1
DOIs	https://doi.org/10.1002/eat.20209
State	Published - Jan 2006
Externally published	Yes

Keywords

Antidepressant medication
Bulimia nervosa
Desipramine
Receiver operating characteristic curves

ASJC Scopus subject areas

Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/eat.20209

Cite this

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title = "Early response to desipramine among women with bulimia nervosa",

abstract = "Objective: Numerous trials have demonstrated the efficacy of antidepressant medications for the treatment of bulimia nervosa (BN). The current study examined whether early response to medication predicted response to medication at the end of a controlled trial. Method: Data from two previously published studies of desipramine (DMI) were used. Seventy-seven patients with BN were included in the analysis. Receiver operating characteristic (ROC) curves were constructed to examine the relation between the percentage reduction in symptoms at each week and failure to respond to antidepressant medication at the end of the trial. Results: Eventual nonresponders to DMI could be reliably identified in the first 2 weeks of treatment. Discussion: The current study provides preliminary evidence that patients with BN who will not respond to antidepressant medication can be identified in the first 2 weeks of treatment.",

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doi = "10.1002/eat.20209",

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AU - Walsh, B. Timothy

AU - Sysko, Robyn

AU - Parides, Michael K.

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N2 - Objective: Numerous trials have demonstrated the efficacy of antidepressant medications for the treatment of bulimia nervosa (BN). The current study examined whether early response to medication predicted response to medication at the end of a controlled trial. Method: Data from two previously published studies of desipramine (DMI) were used. Seventy-seven patients with BN were included in the analysis. Receiver operating characteristic (ROC) curves were constructed to examine the relation between the percentage reduction in symptoms at each week and failure to respond to antidepressant medication at the end of the trial. Results: Eventual nonresponders to DMI could be reliably identified in the first 2 weeks of treatment. Discussion: The current study provides preliminary evidence that patients with BN who will not respond to antidepressant medication can be identified in the first 2 weeks of treatment.

AB - Objective: Numerous trials have demonstrated the efficacy of antidepressant medications for the treatment of bulimia nervosa (BN). The current study examined whether early response to medication predicted response to medication at the end of a controlled trial. Method: Data from two previously published studies of desipramine (DMI) were used. Seventy-seven patients with BN were included in the analysis. Receiver operating characteristic (ROC) curves were constructed to examine the relation between the percentage reduction in symptoms at each week and failure to respond to antidepressant medication at the end of the trial. Results: Eventual nonresponders to DMI could be reliably identified in the first 2 weeks of treatment. Discussion: The current study provides preliminary evidence that patients with BN who will not respond to antidepressant medication can be identified in the first 2 weeks of treatment.

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KW - Bulimia nervosa

KW - Desipramine

KW - Receiver operating characteristic curves

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Early response to desipramine among women with bulimia nervosa

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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