Early response to desipramine among women with bulimia nervosa

B. Timothy Walsh, Robyn Sysko, Michael K. Parides

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Objective: Numerous trials have demonstrated the efficacy of antidepressant medications for the treatment of bulimia nervosa (BN). The current study examined whether early response to medication predicted response to medication at the end of a controlled trial. Method: Data from two previously published studies of desipramine (DMI) were used. Seventy-seven patients with BN were included in the analysis. Receiver operating characteristic (ROC) curves were constructed to examine the relation between the percentage reduction in symptoms at each week and failure to respond to antidepressant medication at the end of the trial. Results: Eventual nonresponders to DMI could be reliably identified in the first 2 weeks of treatment. Discussion: The current study provides preliminary evidence that patients with BN who will not respond to antidepressant medication can be identified in the first 2 weeks of treatment.

Original languageEnglish (US)
Pages (from-to)72-75
Number of pages4
JournalInternational Journal of Eating Disorders
Issue number1
StatePublished - Jan 2006
Externally publishedYes


  • Antidepressant medication
  • Bulimia nervosa
  • Desipramine
  • Receiver operating characteristic curves

ASJC Scopus subject areas

  • Psychiatry and Mental health


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