Dynamic T1-weighted magnetic resonance imaging of interstitial laser photocoagulation in the liver: Observations on in vivo temperature sensitivity

Marvin P. Fried, Paul R. Morrison, Stephen G. Hushek, Gilberto A. Kernahan, Ferenc A. Jolesz

Research output: Contribution to journalArticle

35 Scopus citations


Background and Objective: Magnetic resonance imaging's (MRI) potential to monitor interstitial laser photocoagulation (ILP) has been previously demonstrated and is further tested here with improved spatial and temporal resolution. Study Design/Materials and Methods: In vivo experiments employed fiber-delivered 1,064 nm light (3.0 W, 150 sec) in six rabbit livers monitored under T1-weighted FSE MRI as 1 image/10 sec and a 3 mm thick 8 cm FOV. Image signal intensities (SI) were compared with temperatures (T) at 7, 10, and 15 mm from the fiber. Results: Data showed 33°C < T < 60°C. SI did not vary inverse-linearly with T; changes in the tissue altered the MRI signal interfering with the SI changes due to temperature. Conclusion: MRI cannot map SI-derived temperatures over the entire treatment site. The role of MRI's temperature sensitivity must be coordinated with organ- and dose- specific tissue changes.

Original languageEnglish (US)
Pages (from-to)410-419
Number of pages10
JournalLasers in Surgery and Medicine
Issue number4
Publication statusPublished - Jan 1 1996
Externally publishedYes



  • Nd:YAG
  • interstitial laser photocoagulation ILTT
  • magnetic resonance imaging
  • minimally invasive surgery

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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