Dynamic organization of the bone marrow plasma cell niche

Tonya S. Aaron, David R. Fooksman

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Prophylactic, serological memory relies on maintaining stable reservoirs of plasma cells, capable of constitutively-secreting high-affinity, anti-pathogen antibody for a lifetime. Although antibody titers generated by some vaccines (e.g. measles) can last a lifetime, other vaccinations (e.g. tetanus) need repeated boosting because long-lived plasma cells are not produced or maintained. Moreover, in old age, the ability to generate long-lived humoral responses diminishes. Despite their importance to health, it is unknown how long-lived plasma cells survive over years, whereas most antibody secreting cells die off within weeks after vaccination. In this review, we focus on how known factors regulate the longevity of plasma cell fitness and survival, and how that landscape is shaped by environmental influences, such as inflammation, infection and aging. In addition, we highlight newly discovered cellular dynamics in the bone marrow that may reframe the mechanisms supporting long-lived plasma cell survival and function.

Original languageEnglish (US)
Pages (from-to)4228-4239
Number of pages12
JournalFEBS Journal
Issue number14
StatePublished - Jul 2022


  • CXCR4
  • bone marrow
  • long-lived plasma cells
  • migration

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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