Duration of ruptured membranes and vertical transmission of HIV-1

A meta-analysis from 15 prospective cohort studies

M. B. Bulterys, M. G. Fowler, I. C. Hanson, M. Lemay, M. J. Mayaux, L. Mofenson, M. L. Newell, H. Peavy, C. Peckham, J. S. Read, C. Rother, B. J. Simpson, R. B. Van Dyke, D. R. Harris, H. H. Peavy, K. Easley, A. Khammy, R. P. Nugent, R. Mitchell, W. Owen & 489 others R. Van Dyke, S. Widmayer, A. Bardeguez, C. Hanson, A. Wiznia, K. Luzuriaga, R. Viscarello, D. Ho, R. Koup, I. Chen, P. Krogstad, J. Mullins, S. Wolinsky, B. Korber, B. Walker, A. Ammann, S. Clapp, D. McDonald, N. Lapointe, M. Boucher, M. Fauvel, C. Hankins, J. Samson, M. L. Newell, C. S. Peckham, C. N. Thorne, C. Giaquinto, E. Ruga, A. De Rossi, D. Truscia, I. Grosch-Wörner, A. Schäfer, J. Mok, F. Johnstone, J. Jiminez, C. de Alba, M. C. Garcia Rodriguez, I. Bates, I. de Joseé, F. Hawkins, R. Martinez Zapico, J. M. Peña, J. Gonzalez Garcia, J. R. Arribas Lopez, F. Asensi-Botet, M. C. Otero, D. Peérez-Tamarit, A. Moya, M. J. Galbis, H. Scherpbier, K. Boer, A. B. Bohlin, S. Lindgren, B. Anzen, E. Belfrage, G. Lidin-Jansson, J. Levy, P. Barlow, M. Hainaut, A. Peltier, A. Ferrazin, A. De Maria, C. Gotta, A. Mûr, M. Viñolas, A. Paya, M. A. Loépez-Vilchez, O. Coll, C. Fortuny, J. Boguña, M. Casellas Caro, Y. Canet, G. Pardi, M. Ravizza, E. Semprini, C. Castagna, S. Fiore, B. Guerra, M. Lanari, S. Bianchi, L. Bovicelli, E. Prati, S. Zanelli, M. Duse, A. Soresina, G. Scaravelli, M. Stegagno, M. De Santis, M. L. Muggiasca, A. Viganó, A. Spinillo, F. Ravagni Probizer, A. Bucceri, L. Rancilio, G. P. Taylor, H. Lyall, Z. Penn, M. Blott, N. H. Valerius, P. Martinelli, W. Buffolano, C. Tibaldi, N. Ziarati, A. Semprini, M. Ravizza, C. Castagna, S. Fiore, M. Della Torre, F. Parazzini, L. Bovicelli, B. Guerra, P. Dallacasa, S. Bianchi, U. Bianchi, M. Duse, E. Prati, S. Zanelli, A. Soresina, A. Pachì, G. Scaravelli, M. Stegagno, S. Mancuso, M. De Santis, P. Villa, M. Conti, N. Principi, M. Muggiasca, P. Marchisio, C. Zara, A. Spinillo, F. Ravagni, M. Vignali, A. Bucceri, G. Rossi, L. Rancilio, L. Selvaggi, P. Greco, A. Vimercati, G. Massi, T. Innocenti, A. Fiscella, P. Martinelli, M. Sansone, C. Benedetto, C. Tibaldi, N. Ziarati, B. Tadrist, D. Thevenieau, J. Gondry, B. Paulard, C. Alisy, D. Brault, N. Tordjeman, J. Mamou, M. Rozan, D. Colombani, O. Pincemaille, A. Salvetti, C. Chabanier, X. Hernandorena, J. Leroy, J. Schaal, P. Balde, P. Faucher, E. Lachassinne, S. Benoit, D. Douard, C. Hocke, P. Barjot, J. Brouard, P. Delattre, L. Stien, F. Audibert, P. Labrune, M. Vial, F. Mazy, D. Sitbon, C. Crenn-Hebert, C. Floch-Tudal, R. Akakpo, C. Daveau, A. Leblanc, P. Cesbron, M. Duval-Arnould, C. Huraux-Rendu, S. Lemerle, C. Touboul, M. Guerin, C. Maingueneau, I. Reynaud, T. Rousseau, V. Ercoil, M. Lanza, M. Denavit, J. Garnier, K. Lahsinat, P. Pia, C. Allouche, M. Nardou, F. Grall, A. May, M. Dallot, P. Lhuillier, W. Cecile, R. Mezin, P. Balde, A. Bech, J. Lobut, G. Algava, A. Chalvon Dermesay, R. Busuttil, M. Jacquemot, B. Bader-Meunier, S. Fridman, X. Codaccioni, F. Maxingue, D. Thomas, J. Alain, L. De Lumley, J. Tabaste, P. Bailly Salin, H. Seaume, A. Guichard, K. Kebaïll, C. Roussouly, C. Botto, A. De Lanete, P. Wipff, L. Cravello, P. De Boisse, M. Leclaire, G. Michel, C. Crumiere, V. Lefevre, B. Le Lorier, I. Pauly, B. Robichez, D. Seguy, M. Delhinger, F. Rideau, P. Talon, P. Benos, C. Huret, J. Nicolas, B. Heller-Roussin, S. Saint-Leger, M. Delaporte, C. Hubert, B. De Sarcus, P. Karoubi, F. Mechinaud, D. Bertcrottiere, A. Bongain, F. Monpoux, C. De Gennes, F. Devianne, I. Nisand, M. Rousset, P. Karoubi, G. Mouchnino, J. Muray, M. Munzer, C. Quereux, V. Brossard, B. Clavier, M. Allemon, D. Rotten, J. Stephan, M. Varlet, B. Guyot, P. Narcy, F. Bardinet, F. De Caunes, R. Jeny, M. Robin, A. Raison Boulley, L. Savey, A. Berrebi, J. Tricoire, J. Borderon, A. Fignon, F. Guillot, B. Maria, A. Broyard, Y. Chitrit, G. Firtion, L. Mandelbrot, M. Lafay Pillet, S. Parat, C. Boissinot, N. Garec, M. Levine, A. Ottenwalter, F. Schaller, E. Vilmer, C. Courpotin, C. Brunner, N. Ciraru-Vigneron, G. Hatem-Gantzer, B. Heller-Roussin, X. Fritel, A. Wallet, J. Bouille, J. Milliez, D. Bensaid Mrejen, E. Dermer, G. Noseda, D. Bardou, J. Cressaty, C. Francoual, C. Carlus Moncomble, H. Cohen, S. Blanche, H. Bastion, J. Benifla, F. Benkhatar, N. Berkane, F. Herveé, M. Ronzier, MJ Mayaux, S. Blanche, M. de Martino, P. A. Tovo, L. Galli, C. Gabiano, G. Ferraris, L. Rancilio, A. Bucceri, S. Garetto, E. Palomba, C. Riva, A. Vierucci, M. de Luca, S. Farina, C. Fundarò, O. Genovese, G. Mereu, G. L. Forni, A. Casadei, G. V. Zuccotti, E. Riva, M. Cellini, C. Baraldi, R. Consolini, G. Palla, M. Ruggeri, F. Ciccimarra, A. Guarino, P. Osimani, G. Benaglia, A. Romano, M. Lanari, D. De Mattia, D. Caselli, S. Boni, G. Dell'Erba, F. Bassanetti, M. Sticca, C. Timpano, C. Magnani, C. Salvatore, R. Lipreri, R. Tornaghi, R. Pinzani, M. T. Cecchi, T. Bezzi, L. Battisti, E. Bresciani, G. Castelli Gattinara, C. Nasi, A. Pellegatta, A. Mazza, F. Baldi, E. Ruga, R. Altobelli, M. Deiana, C. Colnaghi, L. Tarallo, U. Tondo, E. Anastasio, M. Duse, P. G. Chiriacò, C. Ruggeri, G. Scott, C. Hutto, M. O'Sullivan, A. Malmsberry, A. Willoughby, D. Burns, J. Goedert, S. Landesman, H. Minkoff, H. Mendez, S. Holman, Arye Rubinstein, S. Durako, L. Muenz, S. Goodwin, Y. Bryson, M. Dillon, K. Nielsen, P. Boyer, D. Liao, M. Keller, A. Deveikis, S. Nesheim, M. Lindsay, F. Lee, A. Nahmias, M. Sawyer, P. Vink, J. Farley, L. Alger, E. Abrams, M. Bamji, G. Lambert, Ellie Schoenbaum, P. Thomas, J. Weedon, P. Palumbo, A. Bardeguez, T. Denny, J. Oleske, M. Bulterys, R. Simonds, J. Ethier-Ives, M. Rogers, M. Schluchter, M. Kutner, S. Kaplan, M. Kattan, S. Lipshultz, R. Mellins, W. Shearer, G. Sopko, E. Sloand, M. Wu, C. Kind, D. Nadal, C. Rudin, C. A. Siegrist, C. A. Wyler, J. J. Cheseaux, C. Aebi, H. Gnehm, G. Schubiger, J. Klingler, U. Hunziker, H. Kuchler, M. Gianinazzi, U. Buhlmann, K. Biedermann, U. Lauper, O. Irion, A. Brunelli, G. Spoletini, A. Schreyer, I. Hosli, E. Saurenmann, G. Drack, M. Isenschmid, M. Poorbeik, J. Schupbach, L. Perrin, P. Erb, H. Joller, A. Kovacs, A. Stek, L. Chan, M. Khoury, C. Diaz, E. Pacheco-Acosta, R. Tuomala, E. Cooper, D. Mesthene, J. Pitt, A. Higgins, H. Mendez, G. Moroso, K. Rich, D. Turpin, C. Hanson, N. Cooper, M. G. Fowler, R. P. Nugent, K. Davenny, B. Thompson, W. Andiman, J. Simpson

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Objective: To test the a priori hypothesis that longer duration of ruptured membranes is associated with increased risk of vertical transmission of HIV. Design: The relationship between duration of ruptured membranes and vertical transmission of HIV was evaluated in an individual patient data meta-analysis. Methods: Eligible studies were prospective cohort studies including at least 100 mother-child pairs, from regions where HIV-infected women are counselled not to breastfeed. Analyses were restricted to vaginal deliveries and non-elective Cesarean sections; elective Cesarean section deliveries (those performed before onset of labour and before rupture of membranes) were excluded. Results: The primary analysis included 4721 deliveries with duration of ruptured membranes ≤ 24 h. After adjusting for other factors known to be associated with vertical transmission using logistic regression analysis to assess the strength of the relationship, the risk of vertical HIV transmission increased approximately 2% with an increase of 1 h in the duration of ruptured membranes [adjusted odds ratio, 1.02; 95% confidence interval, 1.01-1.04; for each 1 h increment]. There were no significant interactions of duration of ruptured membranes with study cohort or with any of the covariates, except maternal AIDS. Among women diagnosed with AIDS, the estimated probability of transmission increased from 8% to 31% with duration of ruptured membranes of 2 h and 24 h respectively (P < 0.01). Conclusions: These results support the importance of duration of ruptured membranes as a risk factor for vertical transmission of HIV and suggest that a diagnosis of AIDS in the mother at the time of delivery may potentiate the effect of duration of ruptured membranes.

Original languageEnglish (US)
Pages (from-to)357-368
Number of pages12
JournalAIDS
Volume15
Issue number3
DOIs
StatePublished - Feb 16 2001
Externally publishedYes

Fingerprint

Meta-Analysis
HIV-1
Cohort Studies
Prospective Studies
Membranes
HIV
Acquired Immunodeficiency Syndrome
Mothers
Cesarean Section
Labor Onset
Rupture
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals

Keywords

  • Epidemiology
  • Obstetrics/gynaecology
  • Prevention of perinatal transmission
  • Vertical transmission

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Bulterys, M. B., Fowler, M. G., Hanson, I. C., Lemay, M., Mayaux, M. J., Mofenson, L., ... Simpson, J. (2001). Duration of ruptured membranes and vertical transmission of HIV-1: A meta-analysis from 15 prospective cohort studies. AIDS, 15(3), 357-368. https://doi.org/10.1097/00002030-200102160-00009

Duration of ruptured membranes and vertical transmission of HIV-1 : A meta-analysis from 15 prospective cohort studies. / Bulterys, M. B.; Fowler, M. G.; Hanson, I. C.; Lemay, M.; Mayaux, M. J.; Mofenson, L.; Newell, M. L.; Peavy, H.; Peckham, C.; Read, J. S.; Rother, C.; Simpson, B. J.; Van Dyke, R. B.; Harris, D. R.; Peavy, H. H.; Easley, K.; Khammy, A.; Nugent, R. P.; Mitchell, R.; Owen, W.; Van Dyke, R.; Widmayer, S.; Bardeguez, A.; Hanson, C.; Wiznia, A.; Luzuriaga, K.; Viscarello, R.; Ho, D.; Koup, R.; Chen, I.; Krogstad, P.; Mullins, J.; Wolinsky, S.; Korber, B.; Walker, B.; Ammann, A.; Clapp, S.; McDonald, D.; Lapointe, N.; Boucher, M.; Fauvel, M.; Hankins, C.; Samson, J.; Newell, M. L.; Peckham, C. S.; Thorne, C. N.; Giaquinto, C.; Ruga, E.; De Rossi, A.; Truscia, D.; Grosch-Wörner, I.; Schäfer, A.; Mok, J.; Johnstone, F.; Jiminez, J.; de Alba, C.; Garcia Rodriguez, M. C.; Bates, I.; de Joseé, I.; Hawkins, F.; Martinez Zapico, R.; Peña, J. M.; Gonzalez Garcia, J.; Arribas Lopez, J. R.; Asensi-Botet, F.; Otero, M. C.; Peérez-Tamarit, D.; Moya, A.; Galbis, M. J.; Scherpbier, H.; Boer, K.; Bohlin, A. B.; Lindgren, S.; Anzen, B.; Belfrage, E.; Lidin-Jansson, G.; Levy, J.; Barlow, P.; Hainaut, M.; Peltier, A.; Ferrazin, A.; De Maria, A.; Gotta, C.; Mûr, A.; Viñolas, M.; Paya, A.; Loépez-Vilchez, M. A.; Coll, O.; Fortuny, C.; Boguña, J.; Casellas Caro, M.; Canet, Y.; Pardi, G.; Ravizza, M.; Semprini, E.; Castagna, C.; Fiore, S.; Guerra, B.; Lanari, M.; Bianchi, S.; Bovicelli, L.; Prati, E.; Zanelli, S.; Duse, M.; Soresina, A.; Scaravelli, G.; Stegagno, M.; De Santis, M.; Muggiasca, M. L.; Viganó, A.; Spinillo, A.; Ravagni Probizer, F.; Bucceri, A.; Rancilio, L.; Taylor, G. P.; Lyall, H.; Penn, Z.; Blott, M.; Valerius, N. H.; Martinelli, P.; Buffolano, W.; Tibaldi, C.; Ziarati, N.; Semprini, A.; Ravizza, M.; Castagna, C.; Fiore, S.; Della Torre, M.; Parazzini, F.; Bovicelli, L.; Guerra, B.; Dallacasa, P.; Bianchi, S.; Bianchi, U.; Duse, M.; Prati, E.; Zanelli, S.; Soresina, A.; Pachì, A.; Scaravelli, G.; Stegagno, M.; Mancuso, S.; De Santis, M.; Villa, P.; Conti, M.; Principi, N.; Muggiasca, M.; Marchisio, P.; Zara, C.; Spinillo, A.; Ravagni, F.; Vignali, M.; Bucceri, A.; Rossi, G.; Rancilio, L.; Selvaggi, L.; Greco, P.; Vimercati, A.; Massi, G.; Innocenti, T.; Fiscella, A.; Martinelli, P.; Sansone, M.; Benedetto, C.; Tibaldi, C.; Ziarati, N.; Tadrist, B.; Thevenieau, D.; Gondry, J.; Paulard, B.; Alisy, C.; Brault, D.; Tordjeman, N.; Mamou, J.; Rozan, M.; Colombani, D.; Pincemaille, O.; Salvetti, A.; Chabanier, C.; Hernandorena, X.; Leroy, J.; Schaal, J.; Balde, P.; Faucher, P.; Lachassinne, E.; Benoit, S.; Douard, D.; Hocke, C.; Barjot, P.; Brouard, J.; Delattre, P.; Stien, L.; Audibert, F.; Labrune, P.; Vial, M.; Mazy, F.; Sitbon, D.; Crenn-Hebert, C.; Floch-Tudal, C.; Akakpo, R.; Daveau, C.; Leblanc, A.; Cesbron, P.; Duval-Arnould, M.; Huraux-Rendu, C.; Lemerle, S.; Touboul, C.; Guerin, M.; Maingueneau, C.; Reynaud, I.; Rousseau, T.; Ercoil, V.; Lanza, M.; Denavit, M.; Garnier, J.; Lahsinat, K.; Pia, P.; Allouche, C.; Nardou, M.; Grall, F.; May, A.; Dallot, M.; Lhuillier, P.; Cecile, W.; Mezin, R.; Balde, P.; Bech, A.; Lobut, J.; Algava, G.; Chalvon Dermesay, A.; Busuttil, R.; Jacquemot, M.; Bader-Meunier, B.; Fridman, S.; Codaccioni, X.; Maxingue, F.; Thomas, D.; Alain, J.; De Lumley, L.; Tabaste, J.; Bailly Salin, P.; Seaume, H.; Guichard, A.; Kebaïll, K.; Roussouly, C.; Botto, C.; De Lanete, A.; Wipff, P.; Cravello, L.; De Boisse, P.; Leclaire, M.; Michel, G.; Crumiere, C.; Lefevre, V.; Le Lorier, B.; Pauly, I.; Robichez, B.; Seguy, D.; Delhinger, M.; Rideau, F.; Talon, P.; Benos, P.; Huret, C.; Nicolas, J.; Heller-Roussin, B.; Saint-Leger, S.; Delaporte, M.; Hubert, C.; De Sarcus, B.; Karoubi, P.; Mechinaud, F.; Bertcrottiere, D.; Bongain, A.; Monpoux, F.; De Gennes, C.; Devianne, F.; Nisand, I.; Rousset, M.; Karoubi, P.; Mouchnino, G.; Muray, J.; Munzer, M.; Quereux, C.; Brossard, V.; Clavier, B.; Allemon, M.; Rotten, D.; Stephan, J.; Varlet, M.; Guyot, B.; Narcy, P.; Bardinet, F.; De Caunes, F.; Jeny, R.; Robin, M.; Raison Boulley, A.; Savey, L.; Berrebi, A.; Tricoire, J.; Borderon, J.; Fignon, A.; Guillot, F.; Maria, B.; Broyard, A.; Chitrit, Y.; Firtion, G.; Mandelbrot, L.; Lafay Pillet, M.; Parat, S.; Boissinot, C.; Garec, N.; Levine, M.; Ottenwalter, A.; Schaller, F.; Vilmer, E.; Courpotin, C.; Brunner, C.; Ciraru-Vigneron, N.; Hatem-Gantzer, G.; Heller-Roussin, B.; Fritel, X.; Wallet, A.; Bouille, J.; Milliez, J.; Bensaid Mrejen, D.; Dermer, E.; Noseda, G.; Bardou, D.; Cressaty, J.; Francoual, C.; Carlus Moncomble, C.; Cohen, H.; Blanche, S.; Bastion, H.; Benifla, J.; Benkhatar, F.; Berkane, N.; Herveé, F.; Ronzier, M.; Mayaux, MJ; Blanche, S.; de Martino, M.; Tovo, P. A.; Galli, L.; Gabiano, C.; Ferraris, G.; Rancilio, L.; Bucceri, A.; Garetto, S.; Palomba, E.; Riva, C.; Vierucci, A.; de Luca, M.; Farina, S.; Fundarò, C.; Genovese, O.; Mereu, G.; Forni, G. L.; Casadei, A.; Zuccotti, G. V.; Riva, E.; Cellini, M.; Baraldi, C.; Consolini, R.; Palla, G.; Ruggeri, M.; Ciccimarra, F.; Guarino, A.; Osimani, P.; Benaglia, G.; Romano, A.; Lanari, M.; De Mattia, D.; Caselli, D.; Boni, S.; Dell'Erba, G.; Bassanetti, F.; Sticca, M.; Timpano, C.; Magnani, C.; Salvatore, C.; Lipreri, R.; Tornaghi, R.; Pinzani, R.; Cecchi, M. T.; Bezzi, T.; Battisti, L.; Bresciani, E.; Castelli Gattinara, G.; Nasi, C.; Pellegatta, A.; Mazza, A.; Baldi, F.; Ruga, E.; Altobelli, R.; Deiana, M.; Colnaghi, C.; Tarallo, L.; Tondo, U.; Anastasio, E.; Duse, M.; Chiriacò, P. G.; Ruggeri, C.; Scott, G.; Hutto, C.; O'Sullivan, M.; Malmsberry, A.; Willoughby, A.; Burns, D.; Goedert, J.; Landesman, S.; Minkoff, H.; Mendez, H.; Holman, S.; Rubinstein, Arye; Durako, S.; Muenz, L.; Goodwin, S.; Bryson, Y.; Dillon, M.; Nielsen, K.; Boyer, P.; Liao, D.; Keller, M.; Deveikis, A.; Nesheim, S.; Lindsay, M.; Lee, F.; Nahmias, A.; Sawyer, M.; Vink, P.; Farley, J.; Alger, L.; Abrams, E.; Bamji, M.; Lambert, G.; Schoenbaum, Ellie; Thomas, P.; Weedon, J.; Palumbo, P.; Bardeguez, A.; Denny, T.; Oleske, J.; Bulterys, M.; Simonds, R.; Ethier-Ives, J.; Rogers, M.; Schluchter, M.; Kutner, M.; Kaplan, S.; Kattan, M.; Lipshultz, S.; Mellins, R.; Shearer, W.; Sopko, G.; Sloand, E.; Wu, M.; Kind, C.; Nadal, D.; Rudin, C.; Siegrist, C. A.; Wyler, C. A.; Cheseaux, J. J.; Aebi, C.; Gnehm, H.; Schubiger, G.; Klingler, J.; Hunziker, U.; Kuchler, H.; Gianinazzi, M.; Buhlmann, U.; Biedermann, K.; Lauper, U.; Irion, O.; Brunelli, A.; Spoletini, G.; Schreyer, A.; Hosli, I.; Saurenmann, E.; Drack, G.; Isenschmid, M.; Poorbeik, M.; Schupbach, J.; Perrin, L.; Erb, P.; Joller, H.; Kovacs, A.; Stek, A.; Chan, L.; Khoury, M.; Diaz, C.; Pacheco-Acosta, E.; Tuomala, R.; Cooper, E.; Mesthene, D.; Pitt, J.; Higgins, A.; Mendez, H.; Moroso, G.; Rich, K.; Turpin, D.; Hanson, C.; Cooper, N.; Fowler, M. G.; Nugent, R. P.; Davenny, K.; Thompson, B.; Andiman, W.; Simpson, J.

In: AIDS, Vol. 15, No. 3, 16.02.2001, p. 357-368.

Research output: Contribution to journalArticle

Bulterys, MB, Fowler, MG, Hanson, IC, Lemay, M, Mayaux, MJ, Mofenson, L, Newell, ML, Peavy, H, Peckham, C, Read, JS, Rother, C, Simpson, BJ, Van Dyke, RB, Harris, DR, Peavy, HH, Easley, K, Khammy, A, Nugent, RP, Mitchell, R, Owen, W, Van Dyke, R, Widmayer, S, Bardeguez, A, Hanson, C, Wiznia, A, Luzuriaga, K, Viscarello, R, Ho, D, Koup, R, Chen, I, Krogstad, P, Mullins, J, Wolinsky, S, Korber, B, Walker, B, Ammann, A, Clapp, S, McDonald, D, Lapointe, N, Boucher, M, Fauvel, M, Hankins, C, Samson, J, Newell, ML, Peckham, CS, Thorne, CN, Giaquinto, C, Ruga, E, De Rossi, A, Truscia, D, Grosch-Wörner, I, Schäfer, A, Mok, J, Johnstone, F, Jiminez, J, de Alba, C, Garcia Rodriguez, MC, Bates, I, de Joseé, I, Hawkins, F, Martinez Zapico, R, Peña, JM, Gonzalez Garcia, J, Arribas Lopez, JR, Asensi-Botet, F, Otero, MC, Peérez-Tamarit, D, Moya, A, Galbis, MJ, Scherpbier, H, Boer, K, Bohlin, AB, Lindgren, S, Anzen, B, Belfrage, E, Lidin-Jansson, G, Levy, J, Barlow, P, Hainaut, M, Peltier, A, Ferrazin, A, De Maria, A, Gotta, C, Mûr, A, Viñolas, M, Paya, A, Loépez-Vilchez, MA, Coll, O, Fortuny, C, Boguña, J, Casellas Caro, M, Canet, Y, Pardi, G, Ravizza, M, Semprini, E, Castagna, C, Fiore, S, Guerra, B, Lanari, M, Bianchi, S, Bovicelli, L, Prati, E, Zanelli, S, Duse, M, Soresina, A, Scaravelli, G, Stegagno, M, De Santis, M, Muggiasca, ML, Viganó, A, Spinillo, A, Ravagni Probizer, F, Bucceri, A, Rancilio, L, Taylor, GP, Lyall, H, Penn, Z, Blott, M, Valerius, NH, Martinelli, P, Buffolano, W, Tibaldi, C, Ziarati, N, Semprini, A, Ravizza, M, Castagna, C, Fiore, S, Della Torre, M, Parazzini, F, Bovicelli, L, Guerra, B, Dallacasa, P, Bianchi, S, Bianchi, U, Duse, M, Prati, E, Zanelli, S, Soresina, A, Pachì, A, Scaravelli, G, Stegagno, M, Mancuso, S, De Santis, M, Villa, P, Conti, M, Principi, N, Muggiasca, M, Marchisio, P, Zara, C, Spinillo, A, Ravagni, F, Vignali, M, Bucceri, A, Rossi, G, Rancilio, L, Selvaggi, L, Greco, P, Vimercati, A, Massi, G, Innocenti, T, Fiscella, A, Martinelli, P, Sansone, M, Benedetto, C, Tibaldi, C, Ziarati, N, Tadrist, B, Thevenieau, D, Gondry, J, Paulard, B, Alisy, C, Brault, D, Tordjeman, N, Mamou, J, Rozan, M, Colombani, D, Pincemaille, O, Salvetti, A, Chabanier, C, Hernandorena, X, Leroy, J, Schaal, J, Balde, P, Faucher, P, Lachassinne, E, Benoit, S, Douard, D, Hocke, C, Barjot, P, Brouard, J, Delattre, P, Stien, L, Audibert, F, Labrune, P, Vial, M, Mazy, F, Sitbon, D, Crenn-Hebert, C, Floch-Tudal, C, Akakpo, R, Daveau, C, Leblanc, A, Cesbron, P, Duval-Arnould, M, Huraux-Rendu, C, Lemerle, S, Touboul, C, Guerin, M, Maingueneau, C, Reynaud, I, Rousseau, T, Ercoil, V, Lanza, M, Denavit, M, Garnier, J, Lahsinat, K, Pia, P, Allouche, C, Nardou, M, Grall, F, May, A, Dallot, M, Lhuillier, P, Cecile, W, Mezin, R, Balde, P, Bech, A, Lobut, J, Algava, G, Chalvon Dermesay, A, Busuttil, R, Jacquemot, M, Bader-Meunier, B, Fridman, S, Codaccioni, X, Maxingue, F, Thomas, D, Alain, J, De Lumley, L, Tabaste, J, Bailly Salin, P, Seaume, H, Guichard, A, Kebaïll, K, Roussouly, C, Botto, C, De Lanete, A, Wipff, P, Cravello, L, De Boisse, P, Leclaire, M, Michel, G, Crumiere, C, Lefevre, V, Le Lorier, B, Pauly, I, Robichez, B, Seguy, D, Delhinger, M, Rideau, F, Talon, P, Benos, P, Huret, C, Nicolas, J, Heller-Roussin, B, Saint-Leger, S, Delaporte, M, Hubert, C, De Sarcus, B, Karoubi, P, Mechinaud, F, Bertcrottiere, D, Bongain, A, Monpoux, F, De Gennes, C, Devianne, F, Nisand, I, Rousset, M, Karoubi, P, Mouchnino, G, Muray, J, Munzer, M, Quereux, C, Brossard, V, Clavier, B, Allemon, M, Rotten, D, Stephan, J, Varlet, M, Guyot, B, Narcy, P, Bardinet, F, De Caunes, F, Jeny, R, Robin, M, Raison Boulley, A, Savey, L, Berrebi, A, Tricoire, J, Borderon, J, Fignon, A, Guillot, F, Maria, B, Broyard, A, Chitrit, Y, Firtion, G, Mandelbrot, L, Lafay Pillet, M, Parat, S, Boissinot, C, Garec, N, Levine, M, Ottenwalter, A, Schaller, F, Vilmer, E, Courpotin, C, Brunner, C, Ciraru-Vigneron, N, Hatem-Gantzer, G, Heller-Roussin, B, Fritel, X, Wallet, A, Bouille, J, Milliez, J, Bensaid Mrejen, D, Dermer, E, Noseda, G, Bardou, D, Cressaty, J, Francoual, C, Carlus Moncomble, C, Cohen, H, Blanche, S, Bastion, H, Benifla, J, Benkhatar, F, Berkane, N, Herveé, F, Ronzier, M, Mayaux, MJ, Blanche, S, de Martino, M, Tovo, PA, Galli, L, Gabiano, C, Ferraris, G, Rancilio, L, Bucceri, A, Garetto, S, Palomba, E, Riva, C, Vierucci, A, de Luca, M, Farina, S, Fundarò, C, Genovese, O, Mereu, G, Forni, GL, Casadei, A, Zuccotti, GV, Riva, E, Cellini, M, Baraldi, C, Consolini, R, Palla, G, Ruggeri, M, Ciccimarra, F, Guarino, A, Osimani, P, Benaglia, G, Romano, A, Lanari, M, De Mattia, D, Caselli, D, Boni, S, Dell'Erba, G, Bassanetti, F, Sticca, M, Timpano, C, Magnani, C, Salvatore, C, Lipreri, R, Tornaghi, R, Pinzani, R, Cecchi, MT, Bezzi, T, Battisti, L, Bresciani, E, Castelli Gattinara, G, Nasi, C, Pellegatta, A, Mazza, A, Baldi, F, Ruga, E, Altobelli, R, Deiana, M, Colnaghi, C, Tarallo, L, Tondo, U, Anastasio, E, Duse, M, Chiriacò, PG, Ruggeri, C, Scott, G, Hutto, C, O'Sullivan, M, Malmsberry, A, Willoughby, A, Burns, D, Goedert, J, Landesman, S, Minkoff, H, Mendez, H, Holman, S, Rubinstein, A, Durako, S, Muenz, L, Goodwin, S, Bryson, Y, Dillon, M, Nielsen, K, Boyer, P, Liao, D, Keller, M, Deveikis, A, Nesheim, S, Lindsay, M, Lee, F, Nahmias, A, Sawyer, M, Vink, P, Farley, J, Alger, L, Abrams, E, Bamji, M, Lambert, G, Schoenbaum, E, Thomas, P, Weedon, J, Palumbo, P, Bardeguez, A, Denny, T, Oleske, J, Bulterys, M, Simonds, R, Ethier-Ives, J, Rogers, M, Schluchter, M, Kutner, M, Kaplan, S, Kattan, M, Lipshultz, S, Mellins, R, Shearer, W, Sopko, G, Sloand, E, Wu, M, Kind, C, Nadal, D, Rudin, C, Siegrist, CA, Wyler, CA, Cheseaux, JJ, Aebi, C, Gnehm, H, Schubiger, G, Klingler, J, Hunziker, U, Kuchler, H, Gianinazzi, M, Buhlmann, U, Biedermann, K, Lauper, U, Irion, O, Brunelli, A, Spoletini, G, Schreyer, A, Hosli, I, Saurenmann, E, Drack, G, Isenschmid, M, Poorbeik, M, Schupbach, J, Perrin, L, Erb, P, Joller, H, Kovacs, A, Stek, A, Chan, L, Khoury, M, Diaz, C, Pacheco-Acosta, E, Tuomala, R, Cooper, E, Mesthene, D, Pitt, J, Higgins, A, Mendez, H, Moroso, G, Rich, K, Turpin, D, Hanson, C, Cooper, N, Fowler, MG, Nugent, RP, Davenny, K, Thompson, B, Andiman, W & Simpson, J 2001, 'Duration of ruptured membranes and vertical transmission of HIV-1: A meta-analysis from 15 prospective cohort studies', AIDS, vol. 15, no. 3, pp. 357-368. https://doi.org/10.1097/00002030-200102160-00009
Bulterys, M. B. ; Fowler, M. G. ; Hanson, I. C. ; Lemay, M. ; Mayaux, M. J. ; Mofenson, L. ; Newell, M. L. ; Peavy, H. ; Peckham, C. ; Read, J. S. ; Rother, C. ; Simpson, B. J. ; Van Dyke, R. B. ; Harris, D. R. ; Peavy, H. H. ; Easley, K. ; Khammy, A. ; Nugent, R. P. ; Mitchell, R. ; Owen, W. ; Van Dyke, R. ; Widmayer, S. ; Bardeguez, A. ; Hanson, C. ; Wiznia, A. ; Luzuriaga, K. ; Viscarello, R. ; Ho, D. ; Koup, R. ; Chen, I. ; Krogstad, P. ; Mullins, J. ; Wolinsky, S. ; Korber, B. ; Walker, B. ; Ammann, A. ; Clapp, S. ; McDonald, D. ; Lapointe, N. ; Boucher, M. ; Fauvel, M. ; Hankins, C. ; Samson, J. ; Newell, M. L. ; Peckham, C. S. ; Thorne, C. N. ; Giaquinto, C. ; Ruga, E. ; De Rossi, A. ; Truscia, D. ; Grosch-Wörner, I. ; Schäfer, A. ; Mok, J. ; Johnstone, F. ; Jiminez, J. ; de Alba, C. ; Garcia Rodriguez, M. C. ; Bates, I. ; de Joseé, I. ; Hawkins, F. ; Martinez Zapico, R. ; Peña, J. M. ; Gonzalez Garcia, J. ; Arribas Lopez, J. R. ; Asensi-Botet, F. ; Otero, M. C. ; Peérez-Tamarit, D. ; Moya, A. ; Galbis, M. J. ; Scherpbier, H. ; Boer, K. ; Bohlin, A. B. ; Lindgren, S. ; Anzen, B. ; Belfrage, E. ; Lidin-Jansson, G. ; Levy, J. ; Barlow, P. ; Hainaut, M. ; Peltier, A. ; Ferrazin, A. ; De Maria, A. ; Gotta, C. ; Mûr, A. ; Viñolas, M. ; Paya, A. ; Loépez-Vilchez, M. A. ; Coll, O. ; Fortuny, C. ; Boguña, J. ; Casellas Caro, M. ; Canet, Y. ; Pardi, G. ; Ravizza, M. ; Semprini, E. ; Castagna, C. ; Fiore, S. ; Guerra, B. ; Lanari, M. ; Bianchi, S. ; Bovicelli, L. ; Prati, E. ; Zanelli, S. ; Duse, M. ; Soresina, A. ; Scaravelli, G. ; Stegagno, M. ; De Santis, M. ; Muggiasca, M. L. ; Viganó, A. ; Spinillo, A. ; Ravagni Probizer, F. ; Bucceri, A. ; Rancilio, L. ; Taylor, G. P. ; Lyall, H. ; Penn, Z. ; Blott, M. ; Valerius, N. H. ; Martinelli, P. ; Buffolano, W. ; Tibaldi, C. ; Ziarati, N. ; Semprini, A. ; Ravizza, M. ; Castagna, C. ; Fiore, S. ; Della Torre, M. ; Parazzini, F. ; Bovicelli, L. ; Guerra, B. ; Dallacasa, P. ; Bianchi, S. ; Bianchi, U. ; Duse, M. ; Prati, E. ; Zanelli, S. ; Soresina, A. ; Pachì, A. ; Scaravelli, G. ; Stegagno, M. ; Mancuso, S. ; De Santis, M. ; Villa, P. ; Conti, M. ; Principi, N. ; Muggiasca, M. ; Marchisio, P. ; Zara, C. ; Spinillo, A. ; Ravagni, F. ; Vignali, M. ; Bucceri, A. ; Rossi, G. ; Rancilio, L. ; Selvaggi, L. ; Greco, P. ; Vimercati, A. ; Massi, G. ; Innocenti, T. ; Fiscella, A. ; Martinelli, P. ; Sansone, M. ; Benedetto, C. ; Tibaldi, C. ; Ziarati, N. ; Tadrist, B. ; Thevenieau, D. ; Gondry, J. ; Paulard, B. ; Alisy, C. ; Brault, D. ; Tordjeman, N. ; Mamou, J. ; Rozan, M. ; Colombani, D. ; Pincemaille, O. ; Salvetti, A. ; Chabanier, C. ; Hernandorena, X. ; Leroy, J. ; Schaal, J. ; Balde, P. ; Faucher, P. ; Lachassinne, E. ; Benoit, S. ; Douard, D. ; Hocke, C. ; Barjot, P. ; Brouard, J. ; Delattre, P. ; Stien, L. ; Audibert, F. ; Labrune, P. ; Vial, M. ; Mazy, F. ; Sitbon, D. ; Crenn-Hebert, C. ; Floch-Tudal, C. ; Akakpo, R. ; Daveau, C. ; Leblanc, A. ; Cesbron, P. ; Duval-Arnould, M. ; Huraux-Rendu, C. ; Lemerle, S. ; Touboul, C. ; Guerin, M. ; Maingueneau, C. ; Reynaud, I. ; Rousseau, T. ; Ercoil, V. ; Lanza, M. ; Denavit, M. ; Garnier, J. ; Lahsinat, K. ; Pia, P. ; Allouche, C. ; Nardou, M. ; Grall, F. ; May, A. ; Dallot, M. ; Lhuillier, P. ; Cecile, W. ; Mezin, R. ; Balde, P. ; Bech, A. ; Lobut, J. ; Algava, G. ; Chalvon Dermesay, A. ; Busuttil, R. ; Jacquemot, M. ; Bader-Meunier, B. ; Fridman, S. ; Codaccioni, X. ; Maxingue, F. ; Thomas, D. ; Alain, J. ; De Lumley, L. ; Tabaste, J. ; Bailly Salin, P. ; Seaume, H. ; Guichard, A. ; Kebaïll, K. ; Roussouly, C. ; Botto, C. ; De Lanete, A. ; Wipff, P. ; Cravello, L. ; De Boisse, P. ; Leclaire, M. ; Michel, G. ; Crumiere, C. ; Lefevre, V. ; Le Lorier, B. ; Pauly, I. ; Robichez, B. ; Seguy, D. ; Delhinger, M. ; Rideau, F. ; Talon, P. ; Benos, P. ; Huret, C. ; Nicolas, J. ; Heller-Roussin, B. ; Saint-Leger, S. ; Delaporte, M. ; Hubert, C. ; De Sarcus, B. ; Karoubi, P. ; Mechinaud, F. ; Bertcrottiere, D. ; Bongain, A. ; Monpoux, F. ; De Gennes, C. ; Devianne, F. ; Nisand, I. ; Rousset, M. ; Karoubi, P. ; Mouchnino, G. ; Muray, J. ; Munzer, M. ; Quereux, C. ; Brossard, V. ; Clavier, B. ; Allemon, M. ; Rotten, D. ; Stephan, J. ; Varlet, M. ; Guyot, B. ; Narcy, P. ; Bardinet, F. ; De Caunes, F. ; Jeny, R. ; Robin, M. ; Raison Boulley, A. ; Savey, L. ; Berrebi, A. ; Tricoire, J. ; Borderon, J. ; Fignon, A. ; Guillot, F. ; Maria, B. ; Broyard, A. ; Chitrit, Y. ; Firtion, G. ; Mandelbrot, L. ; Lafay Pillet, M. ; Parat, S. ; Boissinot, C. ; Garec, N. ; Levine, M. ; Ottenwalter, A. ; Schaller, F. ; Vilmer, E. ; Courpotin, C. ; Brunner, C. ; Ciraru-Vigneron, N. ; Hatem-Gantzer, G. ; Heller-Roussin, B. ; Fritel, X. ; Wallet, A. ; Bouille, J. ; Milliez, J. ; Bensaid Mrejen, D. ; Dermer, E. ; Noseda, G. ; Bardou, D. ; Cressaty, J. ; Francoual, C. ; Carlus Moncomble, C. ; Cohen, H. ; Blanche, S. ; Bastion, H. ; Benifla, J. ; Benkhatar, F. ; Berkane, N. ; Herveé, F. ; Ronzier, M. ; Mayaux, MJ ; Blanche, S. ; de Martino, M. ; Tovo, P. A. ; Galli, L. ; Gabiano, C. ; Ferraris, G. ; Rancilio, L. ; Bucceri, A. ; Garetto, S. ; Palomba, E. ; Riva, C. ; Vierucci, A. ; de Luca, M. ; Farina, S. ; Fundarò, C. ; Genovese, O. ; Mereu, G. ; Forni, G. L. ; Casadei, A. ; Zuccotti, G. V. ; Riva, E. ; Cellini, M. ; Baraldi, C. ; Consolini, R. ; Palla, G. ; Ruggeri, M. ; Ciccimarra, F. ; Guarino, A. ; Osimani, P. ; Benaglia, G. ; Romano, A. ; Lanari, M. ; De Mattia, D. ; Caselli, D. ; Boni, S. ; Dell'Erba, G. ; Bassanetti, F. ; Sticca, M. ; Timpano, C. ; Magnani, C. ; Salvatore, C. ; Lipreri, R. ; Tornaghi, R. ; Pinzani, R. ; Cecchi, M. T. ; Bezzi, T. ; Battisti, L. ; Bresciani, E. ; Castelli Gattinara, G. ; Nasi, C. ; Pellegatta, A. ; Mazza, A. ; Baldi, F. ; Ruga, E. ; Altobelli, R. ; Deiana, M. ; Colnaghi, C. ; Tarallo, L. ; Tondo, U. ; Anastasio, E. ; Duse, M. ; Chiriacò, P. G. ; Ruggeri, C. ; Scott, G. ; Hutto, C. ; O'Sullivan, M. ; Malmsberry, A. ; Willoughby, A. ; Burns, D. ; Goedert, J. ; Landesman, S. ; Minkoff, H. ; Mendez, H. ; Holman, S. ; Rubinstein, Arye ; Durako, S. ; Muenz, L. ; Goodwin, S. ; Bryson, Y. ; Dillon, M. ; Nielsen, K. ; Boyer, P. ; Liao, D. ; Keller, M. ; Deveikis, A. ; Nesheim, S. ; Lindsay, M. ; Lee, F. ; Nahmias, A. ; Sawyer, M. ; Vink, P. ; Farley, J. ; Alger, L. ; Abrams, E. ; Bamji, M. ; Lambert, G. ; Schoenbaum, Ellie ; Thomas, P. ; Weedon, J. ; Palumbo, P. ; Bardeguez, A. ; Denny, T. ; Oleske, J. ; Bulterys, M. ; Simonds, R. ; Ethier-Ives, J. ; Rogers, M. ; Schluchter, M. ; Kutner, M. ; Kaplan, S. ; Kattan, M. ; Lipshultz, S. ; Mellins, R. ; Shearer, W. ; Sopko, G. ; Sloand, E. ; Wu, M. ; Kind, C. ; Nadal, D. ; Rudin, C. ; Siegrist, C. A. ; Wyler, C. A. ; Cheseaux, J. J. ; Aebi, C. ; Gnehm, H. ; Schubiger, G. ; Klingler, J. ; Hunziker, U. ; Kuchler, H. ; Gianinazzi, M. ; Buhlmann, U. ; Biedermann, K. ; Lauper, U. ; Irion, O. ; Brunelli, A. ; Spoletini, G. ; Schreyer, A. ; Hosli, I. ; Saurenmann, E. ; Drack, G. ; Isenschmid, M. ; Poorbeik, M. ; Schupbach, J. ; Perrin, L. ; Erb, P. ; Joller, H. ; Kovacs, A. ; Stek, A. ; Chan, L. ; Khoury, M. ; Diaz, C. ; Pacheco-Acosta, E. ; Tuomala, R. ; Cooper, E. ; Mesthene, D. ; Pitt, J. ; Higgins, A. ; Mendez, H. ; Moroso, G. ; Rich, K. ; Turpin, D. ; Hanson, C. ; Cooper, N. ; Fowler, M. G. ; Nugent, R. P. ; Davenny, K. ; Thompson, B. ; Andiman, W. ; Simpson, J. / Duration of ruptured membranes and vertical transmission of HIV-1 : A meta-analysis from 15 prospective cohort studies. In: AIDS. 2001 ; Vol. 15, No. 3. pp. 357-368.
@article{0b92fcbceb5b40cab51e43eaa0b2cfc4,
title = "Duration of ruptured membranes and vertical transmission of HIV-1: A meta-analysis from 15 prospective cohort studies",
abstract = "Objective: To test the a priori hypothesis that longer duration of ruptured membranes is associated with increased risk of vertical transmission of HIV. Design: The relationship between duration of ruptured membranes and vertical transmission of HIV was evaluated in an individual patient data meta-analysis. Methods: Eligible studies were prospective cohort studies including at least 100 mother-child pairs, from regions where HIV-infected women are counselled not to breastfeed. Analyses were restricted to vaginal deliveries and non-elective Cesarean sections; elective Cesarean section deliveries (those performed before onset of labour and before rupture of membranes) were excluded. Results: The primary analysis included 4721 deliveries with duration of ruptured membranes ≤ 24 h. After adjusting for other factors known to be associated with vertical transmission using logistic regression analysis to assess the strength of the relationship, the risk of vertical HIV transmission increased approximately 2{\%} with an increase of 1 h in the duration of ruptured membranes [adjusted odds ratio, 1.02; 95{\%} confidence interval, 1.01-1.04; for each 1 h increment]. There were no significant interactions of duration of ruptured membranes with study cohort or with any of the covariates, except maternal AIDS. Among women diagnosed with AIDS, the estimated probability of transmission increased from 8{\%} to 31{\%} with duration of ruptured membranes of 2 h and 24 h respectively (P < 0.01). Conclusions: These results support the importance of duration of ruptured membranes as a risk factor for vertical transmission of HIV and suggest that a diagnosis of AIDS in the mother at the time of delivery may potentiate the effect of duration of ruptured membranes.",
keywords = "Epidemiology, Obstetrics/gynaecology, Prevention of perinatal transmission, Vertical transmission",
author = "Bulterys, {M. B.} and Fowler, {M. G.} and Hanson, {I. C.} and M. Lemay and Mayaux, {M. J.} and L. Mofenson and Newell, {M. L.} and H. Peavy and C. Peckham and Read, {J. S.} and C. Rother and Simpson, {B. J.} and {Van Dyke}, {R. B.} and Harris, {D. R.} and Peavy, {H. H.} and K. Easley and A. Khammy and Nugent, {R. P.} and R. Mitchell and W. Owen and {Van Dyke}, R. and S. Widmayer and A. Bardeguez and C. Hanson and A. Wiznia and K. Luzuriaga and R. Viscarello and D. Ho and R. Koup and I. Chen and P. Krogstad and J. Mullins and S. Wolinsky and B. Korber and B. Walker and A. Ammann and S. Clapp and D. McDonald and N. Lapointe and M. Boucher and M. Fauvel and C. Hankins and J. Samson and Newell, {M. L.} and Peckham, {C. S.} and Thorne, {C. N.} and C. Giaquinto and E. Ruga and {De Rossi}, A. and D. Truscia and I. Grosch-W{\"o}rner and A. Sch{\"a}fer and J. Mok and F. Johnstone and J. Jiminez and {de Alba}, C. and {Garcia Rodriguez}, {M. C.} and I. Bates and {de Jose{\'e}}, I. and F. Hawkins and {Martinez Zapico}, R. and Pe{\~n}a, {J. M.} and {Gonzalez Garcia}, J. and {Arribas Lopez}, {J. R.} and F. Asensi-Botet and Otero, {M. C.} and D. Pe{\'e}rez-Tamarit and A. Moya and Galbis, {M. J.} and H. Scherpbier and K. Boer and Bohlin, {A. B.} and S. Lindgren and B. Anzen and E. Belfrage and G. Lidin-Jansson and J. Levy and P. Barlow and M. Hainaut and A. Peltier and A. Ferrazin and {De Maria}, A. and C. Gotta and A. M{\^u}r and M. Vi{\~n}olas and A. Paya and Lo{\'e}pez-Vilchez, {M. A.} and O. Coll and C. Fortuny and J. Bogu{\~n}a and {Casellas Caro}, M. and Y. Canet and G. Pardi and M. Ravizza and E. Semprini and C. Castagna and S. Fiore and B. Guerra and M. Lanari and S. Bianchi and L. Bovicelli and E. Prati and S. Zanelli and M. Duse and A. Soresina and G. Scaravelli and M. Stegagno and {De Santis}, M. and Muggiasca, {M. L.} and A. Vigan{\'o} and A. Spinillo and {Ravagni Probizer}, F. and A. Bucceri and L. Rancilio and Taylor, {G. P.} and H. Lyall and Z. Penn and M. Blott and Valerius, {N. H.} and P. Martinelli and W. Buffolano and C. Tibaldi and N. Ziarati and A. Semprini and M. Ravizza and C. Castagna and S. Fiore and {Della Torre}, M. and F. Parazzini and L. Bovicelli and B. Guerra and P. Dallacasa and S. Bianchi and U. Bianchi and M. Duse and E. Prati and S. Zanelli and A. Soresina and A. Pach{\`i} and G. Scaravelli and M. Stegagno and S. Mancuso and {De Santis}, M. and P. Villa and M. Conti and N. Principi and M. Muggiasca and P. Marchisio and C. Zara and A. Spinillo and F. Ravagni and M. Vignali and A. Bucceri and G. Rossi and L. Rancilio and L. Selvaggi and P. Greco and A. Vimercati and G. Massi and T. Innocenti and A. Fiscella and P. Martinelli and M. Sansone and C. Benedetto and C. Tibaldi and N. Ziarati and B. Tadrist and D. Thevenieau and J. Gondry and B. Paulard and C. Alisy and D. Brault and N. Tordjeman and J. Mamou and M. Rozan and D. Colombani and O. Pincemaille and A. Salvetti and C. Chabanier and X. Hernandorena and J. Leroy and J. Schaal and P. Balde and P. Faucher and E. Lachassinne and S. Benoit and D. Douard and C. Hocke and P. Barjot and J. Brouard and P. Delattre and L. Stien and F. Audibert and P. Labrune and M. Vial and F. Mazy and D. Sitbon and C. Crenn-Hebert and C. Floch-Tudal and R. Akakpo and C. Daveau and A. Leblanc and P. Cesbron and M. Duval-Arnould and C. Huraux-Rendu and S. Lemerle and C. Touboul and M. Guerin and C. Maingueneau and I. Reynaud and T. Rousseau and V. Ercoil and M. Lanza and M. Denavit and J. Garnier and K. Lahsinat and P. Pia and C. Allouche and M. Nardou and F. Grall and A. May and M. Dallot and P. Lhuillier and W. Cecile and R. Mezin and P. Balde and A. Bech and J. Lobut and G. Algava and {Chalvon Dermesay}, A. and R. Busuttil and M. Jacquemot and B. Bader-Meunier and S. Fridman and X. Codaccioni and F. Maxingue and D. Thomas and J. Alain and {De Lumley}, L. and J. Tabaste and {Bailly Salin}, P. and H. Seaume and A. Guichard and K. Keba{\"i}ll and C. Roussouly and C. Botto and {De Lanete}, A. and P. Wipff and L. Cravello and {De Boisse}, P. and M. Leclaire and G. Michel and C. Crumiere and V. Lefevre and {Le Lorier}, B. and I. Pauly and B. Robichez and D. Seguy and M. Delhinger and F. Rideau and P. Talon and P. Benos and C. Huret and J. Nicolas and B. Heller-Roussin and S. Saint-Leger and M. Delaporte and C. Hubert and {De Sarcus}, B. and P. Karoubi and F. Mechinaud and D. Bertcrottiere and A. Bongain and F. Monpoux and {De Gennes}, C. and F. Devianne and I. Nisand and M. Rousset and P. Karoubi and G. Mouchnino and J. Muray and M. Munzer and C. Quereux and V. Brossard and B. Clavier and M. Allemon and D. Rotten and J. Stephan and M. Varlet and B. Guyot and P. Narcy and F. Bardinet and {De Caunes}, F. and R. Jeny and M. Robin and {Raison Boulley}, A. and L. Savey and A. Berrebi and J. Tricoire and J. Borderon and A. Fignon and F. Guillot and B. Maria and A. Broyard and Y. Chitrit and G. Firtion and L. Mandelbrot and {Lafay Pillet}, M. and S. Parat and C. Boissinot and N. Garec and M. Levine and A. Ottenwalter and F. Schaller and E. Vilmer and C. Courpotin and C. Brunner and N. Ciraru-Vigneron and G. Hatem-Gantzer and B. Heller-Roussin and X. Fritel and A. Wallet and J. Bouille and J. Milliez and {Bensaid Mrejen}, D. and E. Dermer and G. Noseda and D. Bardou and J. Cressaty and C. Francoual and {Carlus Moncomble}, C. and H. Cohen and S. Blanche and H. Bastion and J. Benifla and F. Benkhatar and N. Berkane and F. Herve{\'e} and M. Ronzier and MJ Mayaux and S. Blanche and {de Martino}, M. and Tovo, {P. A.} and L. Galli and C. Gabiano and G. Ferraris and L. Rancilio and A. Bucceri and S. Garetto and E. Palomba and C. Riva and A. Vierucci and {de Luca}, M. and S. Farina and C. Fundar{\`o} and O. Genovese and G. Mereu and Forni, {G. L.} and A. Casadei and Zuccotti, {G. V.} and E. Riva and M. Cellini and C. Baraldi and R. Consolini and G. Palla and M. Ruggeri and F. Ciccimarra and A. Guarino and P. Osimani and G. Benaglia and A. Romano and M. Lanari and {De Mattia}, D. and D. Caselli and S. Boni and G. Dell'Erba and F. Bassanetti and M. Sticca and C. Timpano and C. Magnani and C. Salvatore and R. Lipreri and R. Tornaghi and R. Pinzani and Cecchi, {M. T.} and T. Bezzi and L. Battisti and E. Bresciani and {Castelli Gattinara}, G. and C. Nasi and A. Pellegatta and A. Mazza and F. Baldi and E. Ruga and R. Altobelli and M. Deiana and C. Colnaghi and L. Tarallo and U. Tondo and E. Anastasio and M. Duse and Chiriac{\`o}, {P. G.} and C. Ruggeri and G. Scott and C. Hutto and M. O'Sullivan and A. Malmsberry and A. Willoughby and D. Burns and J. Goedert and S. Landesman and H. Minkoff and H. Mendez and S. Holman and Arye Rubinstein and S. Durako and L. Muenz and S. Goodwin and Y. Bryson and M. Dillon and K. Nielsen and P. Boyer and D. Liao and M. Keller and A. Deveikis and S. Nesheim and M. Lindsay and F. Lee and A. Nahmias and M. Sawyer and P. Vink and J. Farley and L. Alger and E. Abrams and M. Bamji and G. Lambert and Ellie Schoenbaum and P. Thomas and J. Weedon and P. Palumbo and A. Bardeguez and T. Denny and J. Oleske and M. Bulterys and R. Simonds and J. Ethier-Ives and M. Rogers and M. Schluchter and M. Kutner and S. Kaplan and M. Kattan and S. Lipshultz and R. Mellins and W. Shearer and G. Sopko and E. Sloand and M. Wu and C. Kind and D. Nadal and C. Rudin and Siegrist, {C. A.} and Wyler, {C. A.} and Cheseaux, {J. J.} and C. Aebi and H. Gnehm and G. Schubiger and J. Klingler and U. Hunziker and H. Kuchler and M. Gianinazzi and U. Buhlmann and K. Biedermann and U. Lauper and O. Irion and A. Brunelli and G. Spoletini and A. Schreyer and I. Hosli and E. Saurenmann and G. Drack and M. Isenschmid and M. Poorbeik and J. Schupbach and L. Perrin and P. Erb and H. Joller and A. Kovacs and A. Stek and L. Chan and M. Khoury and C. Diaz and E. Pacheco-Acosta and R. Tuomala and E. Cooper and D. Mesthene and J. Pitt and A. Higgins and H. Mendez and G. Moroso and K. Rich and D. Turpin and C. Hanson and N. Cooper and Fowler, {M. G.} and Nugent, {R. P.} and K. Davenny and B. Thompson and W. Andiman and J. Simpson",
year = "2001",
month = "2",
day = "16",
doi = "10.1097/00002030-200102160-00009",
language = "English (US)",
volume = "15",
pages = "357--368",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Duration of ruptured membranes and vertical transmission of HIV-1

T2 - A meta-analysis from 15 prospective cohort studies

AU - Bulterys, M. B.

AU - Fowler, M. G.

AU - Hanson, I. C.

AU - Lemay, M.

AU - Mayaux, M. J.

AU - Mofenson, L.

AU - Newell, M. L.

AU - Peavy, H.

AU - Peckham, C.

AU - Read, J. S.

AU - Rother, C.

AU - Simpson, B. J.

AU - Van Dyke, R. B.

AU - Harris, D. R.

AU - Peavy, H. H.

AU - Easley, K.

AU - Khammy, A.

AU - Nugent, R. P.

AU - Mitchell, R.

AU - Owen, W.

AU - Van Dyke, R.

AU - Widmayer, S.

AU - Bardeguez, A.

AU - Hanson, C.

AU - Wiznia, A.

AU - Luzuriaga, K.

AU - Viscarello, R.

AU - Ho, D.

AU - Koup, R.

AU - Chen, I.

AU - Krogstad, P.

AU - Mullins, J.

AU - Wolinsky, S.

AU - Korber, B.

AU - Walker, B.

AU - Ammann, A.

AU - Clapp, S.

AU - McDonald, D.

AU - Lapointe, N.

AU - Boucher, M.

AU - Fauvel, M.

AU - Hankins, C.

AU - Samson, J.

AU - Newell, M. L.

AU - Peckham, C. S.

AU - Thorne, C. N.

AU - Giaquinto, C.

AU - Ruga, E.

AU - De Rossi, A.

AU - Truscia, D.

AU - Grosch-Wörner, I.

AU - Schäfer, A.

AU - Mok, J.

AU - Johnstone, F.

AU - Jiminez, J.

AU - de Alba, C.

AU - Garcia Rodriguez, M. C.

AU - Bates, I.

AU - de Joseé, I.

AU - Hawkins, F.

AU - Martinez Zapico, R.

AU - Peña, J. M.

AU - Gonzalez Garcia, J.

AU - Arribas Lopez, J. R.

AU - Asensi-Botet, F.

AU - Otero, M. C.

AU - Peérez-Tamarit, D.

AU - Moya, A.

AU - Galbis, M. J.

AU - Scherpbier, H.

AU - Boer, K.

AU - Bohlin, A. B.

AU - Lindgren, S.

AU - Anzen, B.

AU - Belfrage, E.

AU - Lidin-Jansson, G.

AU - Levy, J.

AU - Barlow, P.

AU - Hainaut, M.

AU - Peltier, A.

AU - Ferrazin, A.

AU - De Maria, A.

AU - Gotta, C.

AU - Mûr, A.

AU - Viñolas, M.

AU - Paya, A.

AU - Loépez-Vilchez, M. A.

AU - Coll, O.

AU - Fortuny, C.

AU - Boguña, J.

AU - Casellas Caro, M.

AU - Canet, Y.

AU - Pardi, G.

AU - Ravizza, M.

AU - Semprini, E.

AU - Castagna, C.

AU - Fiore, S.

AU - Guerra, B.

AU - Lanari, M.

AU - Bianchi, S.

AU - Bovicelli, L.

AU - Prati, E.

AU - Zanelli, S.

AU - Duse, M.

AU - Soresina, A.

AU - Scaravelli, G.

AU - Stegagno, M.

AU - De Santis, M.

AU - Muggiasca, M. L.

AU - Viganó, A.

AU - Spinillo, A.

AU - Ravagni Probizer, F.

AU - Bucceri, A.

AU - Rancilio, L.

AU - Taylor, G. P.

AU - Lyall, H.

AU - Penn, Z.

AU - Blott, M.

AU - Valerius, N. H.

AU - Martinelli, P.

AU - Buffolano, W.

AU - Tibaldi, C.

AU - Ziarati, N.

AU - Semprini, A.

AU - Ravizza, M.

AU - Castagna, C.

AU - Fiore, S.

AU - Della Torre, M.

AU - Parazzini, F.

AU - Bovicelli, L.

AU - Guerra, B.

AU - Dallacasa, P.

AU - Bianchi, S.

AU - Bianchi, U.

AU - Duse, M.

AU - Prati, E.

AU - Zanelli, S.

AU - Soresina, A.

AU - Pachì, A.

AU - Scaravelli, G.

AU - Stegagno, M.

AU - Mancuso, S.

AU - De Santis, M.

AU - Villa, P.

AU - Conti, M.

AU - Principi, N.

AU - Muggiasca, M.

AU - Marchisio, P.

AU - Zara, C.

AU - Spinillo, A.

AU - Ravagni, F.

AU - Vignali, M.

AU - Bucceri, A.

AU - Rossi, G.

AU - Rancilio, L.

AU - Selvaggi, L.

AU - Greco, P.

AU - Vimercati, A.

AU - Massi, G.

AU - Innocenti, T.

AU - Fiscella, A.

AU - Martinelli, P.

AU - Sansone, M.

AU - Benedetto, C.

AU - Tibaldi, C.

AU - Ziarati, N.

AU - Tadrist, B.

AU - Thevenieau, D.

AU - Gondry, J.

AU - Paulard, B.

AU - Alisy, C.

AU - Brault, D.

AU - Tordjeman, N.

AU - Mamou, J.

AU - Rozan, M.

AU - Colombani, D.

AU - Pincemaille, O.

AU - Salvetti, A.

AU - Chabanier, C.

AU - Hernandorena, X.

AU - Leroy, J.

AU - Schaal, J.

AU - Balde, P.

AU - Faucher, P.

AU - Lachassinne, E.

AU - Benoit, S.

AU - Douard, D.

AU - Hocke, C.

AU - Barjot, P.

AU - Brouard, J.

AU - Delattre, P.

AU - Stien, L.

AU - Audibert, F.

AU - Labrune, P.

AU - Vial, M.

AU - Mazy, F.

AU - Sitbon, D.

AU - Crenn-Hebert, C.

AU - Floch-Tudal, C.

AU - Akakpo, R.

AU - Daveau, C.

AU - Leblanc, A.

AU - Cesbron, P.

AU - Duval-Arnould, M.

AU - Huraux-Rendu, C.

AU - Lemerle, S.

AU - Touboul, C.

AU - Guerin, M.

AU - Maingueneau, C.

AU - Reynaud, I.

AU - Rousseau, T.

AU - Ercoil, V.

AU - Lanza, M.

AU - Denavit, M.

AU - Garnier, J.

AU - Lahsinat, K.

AU - Pia, P.

AU - Allouche, C.

AU - Nardou, M.

AU - Grall, F.

AU - May, A.

AU - Dallot, M.

AU - Lhuillier, P.

AU - Cecile, W.

AU - Mezin, R.

AU - Balde, P.

AU - Bech, A.

AU - Lobut, J.

AU - Algava, G.

AU - Chalvon Dermesay, A.

AU - Busuttil, R.

AU - Jacquemot, M.

AU - Bader-Meunier, B.

AU - Fridman, S.

AU - Codaccioni, X.

AU - Maxingue, F.

AU - Thomas, D.

AU - Alain, J.

AU - De Lumley, L.

AU - Tabaste, J.

AU - Bailly Salin, P.

AU - Seaume, H.

AU - Guichard, A.

AU - Kebaïll, K.

AU - Roussouly, C.

AU - Botto, C.

AU - De Lanete, A.

AU - Wipff, P.

AU - Cravello, L.

AU - De Boisse, P.

AU - Leclaire, M.

AU - Michel, G.

AU - Crumiere, C.

AU - Lefevre, V.

AU - Le Lorier, B.

AU - Pauly, I.

AU - Robichez, B.

AU - Seguy, D.

AU - Delhinger, M.

AU - Rideau, F.

AU - Talon, P.

AU - Benos, P.

AU - Huret, C.

AU - Nicolas, J.

AU - Heller-Roussin, B.

AU - Saint-Leger, S.

AU - Delaporte, M.

AU - Hubert, C.

AU - De Sarcus, B.

AU - Karoubi, P.

AU - Mechinaud, F.

AU - Bertcrottiere, D.

AU - Bongain, A.

AU - Monpoux, F.

AU - De Gennes, C.

AU - Devianne, F.

AU - Nisand, I.

AU - Rousset, M.

AU - Karoubi, P.

AU - Mouchnino, G.

AU - Muray, J.

AU - Munzer, M.

AU - Quereux, C.

AU - Brossard, V.

AU - Clavier, B.

AU - Allemon, M.

AU - Rotten, D.

AU - Stephan, J.

AU - Varlet, M.

AU - Guyot, B.

AU - Narcy, P.

AU - Bardinet, F.

AU - De Caunes, F.

AU - Jeny, R.

AU - Robin, M.

AU - Raison Boulley, A.

AU - Savey, L.

AU - Berrebi, A.

AU - Tricoire, J.

AU - Borderon, J.

AU - Fignon, A.

AU - Guillot, F.

AU - Maria, B.

AU - Broyard, A.

AU - Chitrit, Y.

AU - Firtion, G.

AU - Mandelbrot, L.

AU - Lafay Pillet, M.

AU - Parat, S.

AU - Boissinot, C.

AU - Garec, N.

AU - Levine, M.

AU - Ottenwalter, A.

AU - Schaller, F.

AU - Vilmer, E.

AU - Courpotin, C.

AU - Brunner, C.

AU - Ciraru-Vigneron, N.

AU - Hatem-Gantzer, G.

AU - Heller-Roussin, B.

AU - Fritel, X.

AU - Wallet, A.

AU - Bouille, J.

AU - Milliez, J.

AU - Bensaid Mrejen, D.

AU - Dermer, E.

AU - Noseda, G.

AU - Bardou, D.

AU - Cressaty, J.

AU - Francoual, C.

AU - Carlus Moncomble, C.

AU - Cohen, H.

AU - Blanche, S.

AU - Bastion, H.

AU - Benifla, J.

AU - Benkhatar, F.

AU - Berkane, N.

AU - Herveé, F.

AU - Ronzier, M.

AU - Mayaux, MJ

AU - Blanche, S.

AU - de Martino, M.

AU - Tovo, P. A.

AU - Galli, L.

AU - Gabiano, C.

AU - Ferraris, G.

AU - Rancilio, L.

AU - Bucceri, A.

AU - Garetto, S.

AU - Palomba, E.

AU - Riva, C.

AU - Vierucci, A.

AU - de Luca, M.

AU - Farina, S.

AU - Fundarò, C.

AU - Genovese, O.

AU - Mereu, G.

AU - Forni, G. L.

AU - Casadei, A.

AU - Zuccotti, G. V.

AU - Riva, E.

AU - Cellini, M.

AU - Baraldi, C.

AU - Consolini, R.

AU - Palla, G.

AU - Ruggeri, M.

AU - Ciccimarra, F.

AU - Guarino, A.

AU - Osimani, P.

AU - Benaglia, G.

AU - Romano, A.

AU - Lanari, M.

AU - De Mattia, D.

AU - Caselli, D.

AU - Boni, S.

AU - Dell'Erba, G.

AU - Bassanetti, F.

AU - Sticca, M.

AU - Timpano, C.

AU - Magnani, C.

AU - Salvatore, C.

AU - Lipreri, R.

AU - Tornaghi, R.

AU - Pinzani, R.

AU - Cecchi, M. T.

AU - Bezzi, T.

AU - Battisti, L.

AU - Bresciani, E.

AU - Castelli Gattinara, G.

AU - Nasi, C.

AU - Pellegatta, A.

AU - Mazza, A.

AU - Baldi, F.

AU - Ruga, E.

AU - Altobelli, R.

AU - Deiana, M.

AU - Colnaghi, C.

AU - Tarallo, L.

AU - Tondo, U.

AU - Anastasio, E.

AU - Duse, M.

AU - Chiriacò, P. G.

AU - Ruggeri, C.

AU - Scott, G.

AU - Hutto, C.

AU - O'Sullivan, M.

AU - Malmsberry, A.

AU - Willoughby, A.

AU - Burns, D.

AU - Goedert, J.

AU - Landesman, S.

AU - Minkoff, H.

AU - Mendez, H.

AU - Holman, S.

AU - Rubinstein, Arye

AU - Durako, S.

AU - Muenz, L.

AU - Goodwin, S.

AU - Bryson, Y.

AU - Dillon, M.

AU - Nielsen, K.

AU - Boyer, P.

AU - Liao, D.

AU - Keller, M.

AU - Deveikis, A.

AU - Nesheim, S.

AU - Lindsay, M.

AU - Lee, F.

AU - Nahmias, A.

AU - Sawyer, M.

AU - Vink, P.

AU - Farley, J.

AU - Alger, L.

AU - Abrams, E.

AU - Bamji, M.

AU - Lambert, G.

AU - Schoenbaum, Ellie

AU - Thomas, P.

AU - Weedon, J.

AU - Palumbo, P.

AU - Bardeguez, A.

AU - Denny, T.

AU - Oleske, J.

AU - Bulterys, M.

AU - Simonds, R.

AU - Ethier-Ives, J.

AU - Rogers, M.

AU - Schluchter, M.

AU - Kutner, M.

AU - Kaplan, S.

AU - Kattan, M.

AU - Lipshultz, S.

AU - Mellins, R.

AU - Shearer, W.

AU - Sopko, G.

AU - Sloand, E.

AU - Wu, M.

AU - Kind, C.

AU - Nadal, D.

AU - Rudin, C.

AU - Siegrist, C. A.

AU - Wyler, C. A.

AU - Cheseaux, J. J.

AU - Aebi, C.

AU - Gnehm, H.

AU - Schubiger, G.

AU - Klingler, J.

AU - Hunziker, U.

AU - Kuchler, H.

AU - Gianinazzi, M.

AU - Buhlmann, U.

AU - Biedermann, K.

AU - Lauper, U.

AU - Irion, O.

AU - Brunelli, A.

AU - Spoletini, G.

AU - Schreyer, A.

AU - Hosli, I.

AU - Saurenmann, E.

AU - Drack, G.

AU - Isenschmid, M.

AU - Poorbeik, M.

AU - Schupbach, J.

AU - Perrin, L.

AU - Erb, P.

AU - Joller, H.

AU - Kovacs, A.

AU - Stek, A.

AU - Chan, L.

AU - Khoury, M.

AU - Diaz, C.

AU - Pacheco-Acosta, E.

AU - Tuomala, R.

AU - Cooper, E.

AU - Mesthene, D.

AU - Pitt, J.

AU - Higgins, A.

AU - Mendez, H.

AU - Moroso, G.

AU - Rich, K.

AU - Turpin, D.

AU - Hanson, C.

AU - Cooper, N.

AU - Fowler, M. G.

AU - Nugent, R. P.

AU - Davenny, K.

AU - Thompson, B.

AU - Andiman, W.

AU - Simpson, J.

PY - 2001/2/16

Y1 - 2001/2/16

N2 - Objective: To test the a priori hypothesis that longer duration of ruptured membranes is associated with increased risk of vertical transmission of HIV. Design: The relationship between duration of ruptured membranes and vertical transmission of HIV was evaluated in an individual patient data meta-analysis. Methods: Eligible studies were prospective cohort studies including at least 100 mother-child pairs, from regions where HIV-infected women are counselled not to breastfeed. Analyses were restricted to vaginal deliveries and non-elective Cesarean sections; elective Cesarean section deliveries (those performed before onset of labour and before rupture of membranes) were excluded. Results: The primary analysis included 4721 deliveries with duration of ruptured membranes ≤ 24 h. After adjusting for other factors known to be associated with vertical transmission using logistic regression analysis to assess the strength of the relationship, the risk of vertical HIV transmission increased approximately 2% with an increase of 1 h in the duration of ruptured membranes [adjusted odds ratio, 1.02; 95% confidence interval, 1.01-1.04; for each 1 h increment]. There were no significant interactions of duration of ruptured membranes with study cohort or with any of the covariates, except maternal AIDS. Among women diagnosed with AIDS, the estimated probability of transmission increased from 8% to 31% with duration of ruptured membranes of 2 h and 24 h respectively (P < 0.01). Conclusions: These results support the importance of duration of ruptured membranes as a risk factor for vertical transmission of HIV and suggest that a diagnosis of AIDS in the mother at the time of delivery may potentiate the effect of duration of ruptured membranes.

AB - Objective: To test the a priori hypothesis that longer duration of ruptured membranes is associated with increased risk of vertical transmission of HIV. Design: The relationship between duration of ruptured membranes and vertical transmission of HIV was evaluated in an individual patient data meta-analysis. Methods: Eligible studies were prospective cohort studies including at least 100 mother-child pairs, from regions where HIV-infected women are counselled not to breastfeed. Analyses were restricted to vaginal deliveries and non-elective Cesarean sections; elective Cesarean section deliveries (those performed before onset of labour and before rupture of membranes) were excluded. Results: The primary analysis included 4721 deliveries with duration of ruptured membranes ≤ 24 h. After adjusting for other factors known to be associated with vertical transmission using logistic regression analysis to assess the strength of the relationship, the risk of vertical HIV transmission increased approximately 2% with an increase of 1 h in the duration of ruptured membranes [adjusted odds ratio, 1.02; 95% confidence interval, 1.01-1.04; for each 1 h increment]. There were no significant interactions of duration of ruptured membranes with study cohort or with any of the covariates, except maternal AIDS. Among women diagnosed with AIDS, the estimated probability of transmission increased from 8% to 31% with duration of ruptured membranes of 2 h and 24 h respectively (P < 0.01). Conclusions: These results support the importance of duration of ruptured membranes as a risk factor for vertical transmission of HIV and suggest that a diagnosis of AIDS in the mother at the time of delivery may potentiate the effect of duration of ruptured membranes.

KW - Epidemiology

KW - Obstetrics/gynaecology

KW - Prevention of perinatal transmission

KW - Vertical transmission

UR - http://www.scopus.com/inward/record.url?scp=0035895603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035895603&partnerID=8YFLogxK

U2 - 10.1097/00002030-200102160-00009

DO - 10.1097/00002030-200102160-00009

M3 - Article

VL - 15

SP - 357

EP - 368

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 3

ER -