Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy

Bouchra Zerhouni-Layachi, Mohammad Husain, Michael J. Ross, Daniele Marras, Masaaki Sunamoto, Xinyan Liu, Paul E. Klotman, Mary E. Klotman

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The phenotype of HIV-1 gp120 envelope derived from renal epithelium and peripheral blood mononuclear cells (PBMC) of patients with HIV-associated nephropathy was investigated in vitro. Chimeric viruses were derived from kidney or blood and used to infect primary CD4+T cells, cell lines expressing single co-receptors and a renal epithelial cell line HPT-1. HIV-1 variants derived from renal epithelium were dual tropic whereas simultaneously derived viruses from PBMC were R5-tropic. Utilization of alternative co-receptors CCR3, BONZO and BOB, also differed.

Original languageEnglish (US)
Pages (from-to)621-624
Number of pages4
JournalAIDS
Volume20
Issue number4
DOIs
StatePublished - Feb 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Zerhouni-Layachi, B., Husain, M., Ross, M. J., Marras, D., Sunamoto, M., Liu, X., Klotman, P. E., & Klotman, M. E. (2006). Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy. AIDS, 20(4), 621-624. https://doi.org/10.1097/01.aids.0000210618.68083.8e