Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy

Bouchra Zerhouni-Layachi, Mohammad Husain, Michael J. Ross, Daniele Marras, Masaaki Sunamoto, Xinyan Liu, Paul E. Klotman, Mary E. Klotman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The phenotype of HIV-1 gp120 envelope derived from renal epithelium and peripheral blood mononuclear cells (PBMC) of patients with HIV-associated nephropathy was investigated in vitro. Chimeric viruses were derived from kidney or blood and used to infect primary CD4+T cells, cell lines expressing single co-receptors and a renal epithelial cell line HPT-1. HIV-1 variants derived from renal epithelium were dual tropic whereas simultaneously derived viruses from PBMC were R5-tropic. Utilization of alternative co-receptors CCR3, BONZO and BOB, also differed.

Original languageEnglish (US)
Pages (from-to)621-624
Number of pages4
JournalAIDS
Volume20
Issue number4
DOIs
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

AIDS-Associated Nephropathy
Tropism
HIV-1
Epithelial Cells
Kidney
Blood Cells
CCR3 Receptors
Epithelium
Viruses
Cell Line
T-Lymphocytes
Phenotype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy. / Zerhouni-Layachi, Bouchra; Husain, Mohammad; Ross, Michael J.; Marras, Daniele; Sunamoto, Masaaki; Liu, Xinyan; Klotman, Paul E.; Klotman, Mary E.

In: AIDS, Vol. 20, No. 4, 02.2006, p. 621-624.

Research output: Contribution to journalArticle

Zerhouni-Layachi, B, Husain, M, Ross, MJ, Marras, D, Sunamoto, M, Liu, X, Klotman, PE & Klotman, ME 2006, 'Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy', AIDS, vol. 20, no. 4, pp. 621-624. https://doi.org/10.1097/01.aids.0000210618.68083.8e
Zerhouni-Layachi, Bouchra ; Husain, Mohammad ; Ross, Michael J. ; Marras, Daniele ; Sunamoto, Masaaki ; Liu, Xinyan ; Klotman, Paul E. ; Klotman, Mary E. / Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy. In: AIDS. 2006 ; Vol. 20, No. 4. pp. 621-624.
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