Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy

Bouchra Zerhouni-Layachi; Mohammad Husain; Michael J. Ross; Daniele Marras; Masaaki Sunamoto; Xinyan Liu; Paul E. Klotman; Mary E. Klotman

doi:10.1097/01.aids.0000210618.68083.8e

Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy

Bouchra Zerhouni-Layachi, Mohammad Husain, Michael J. Ross, Daniele Marras, Masaaki Sunamoto, Xinyan Liu, Paul E. Klotman, Mary E. Klotman

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The phenotype of HIV-1 gp120 envelope derived from renal epithelium and peripheral blood mononuclear cells (PBMC) of patients with HIV-associated nephropathy was investigated in vitro. Chimeric viruses were derived from kidney or blood and used to infect primary CD4+T cells, cell lines expressing single co-receptors and a renal epithelial cell line HPT-1. HIV-1 variants derived from renal epithelium were dual tropic whereas simultaneously derived viruses from PBMC were R5-tropic. Utilization of alternative co-receptors CCR3, BONZO and BOB, also differed.

Original language	English (US)
Pages (from-to)	621-624
Number of pages	4
Journal	AIDS
Volume	20
Issue number	4
DOIs	https://doi.org/10.1097/01.aids.0000210618.68083.8e
State	Published - Feb 1 2006
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/01.aids.0000210618.68083.8e

Cite this

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abstract = "The phenotype of HIV-1 gp120 envelope derived from renal epithelium and peripheral blood mononuclear cells (PBMC) of patients with HIV-associated nephropathy was investigated in vitro. Chimeric viruses were derived from kidney or blood and used to infect primary CD4+T cells, cell lines expressing single co-receptors and a renal epithelial cell line HPT-1. HIV-1 variants derived from renal epithelium were dual tropic whereas simultaneously derived viruses from PBMC were R5-tropic. Utilization of alternative co-receptors CCR3, BONZO and BOB, also differed.",

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AU - Zerhouni-Layachi, Bouchra

AU - Husain, Mohammad

AU - Ross, Michael J.

AU - Marras, Daniele

AU - Sunamoto, Masaaki

AU - Liu, Xinyan

AU - Klotman, Paul E.

AU - Klotman, Mary E.

PY - 2006/2/1

Y1 - 2006/2/1

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Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy

Abstract

ASJC Scopus subject areas

UN SDGs

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