Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance

Kun Chen, Xiaoting Luan, Qisha Liu, Jianwei Wang, Xinxia Chang, Antoine M. Snijders, Jian Hua Mao, Julie Secombe, Zhou Dan, Jian Huan Chen, Zibin Wang, Xiao Dong, Chen Qiu, Xiaoai Chang, Dong Zhang, Susan E. Celniker, Xingyin Liu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Loss-of-function mutations in the histone demethylases KDM5A, KDM5B, or KDM5C are found in intellectual disability (ID) and autism spectrum disorders (ASD) patients. Here, we use the model organism Drosophila melanogaster to delineate how KDM5 contributes to ID and ASD. We show that reducing KDM5 causes intestinal barrier dysfunction and changes in social behavior that correlates with compositional changes in the gut microbiota. Therapeutic alteration of the dysbiotic microbiota through antibiotic administration or feeding with a probiotic Lactobacillus strain partially rescues the behavioral, lifespan, and cellular phenotypes observed in kdm5-deficient flies. Mechanistically, KDM5 was found to transcriptionally regulate component genes of the immune deficiency (IMD) signaling pathway and subsequent maintenance of host-commensal bacteria homeostasis in a demethylase-dependent manner. Together, our study uses a genetic approach to dissect the role of KDM5 in the gut-microbiome-brain axis and suggests that modifying the gut microbiome may provide therapeutic benefits for ID and ASD patients. Mutations in members of the KDM5 gene family are found in intellectual disability and autism spectrum disorder patients. Chen et al. discovered that KDM5-microbiota interactions contribute to animal social behavior. Drosophila deficient in kdm5 display gut dysbiosis, abnormal social behavior, and aberrant immune activation, which Lactobacillus plantarum administration can improve.

Original languageEnglish (US)
Pages (from-to)537-552.e8
JournalCell Host and Microbe
Volume25
Issue number4
DOIs
StatePublished - Apr 10 2019

Fingerprint

Histone Demethylases
Social Behavior
Intellectual Disability
Drosophila
Maintenance
Microbiota
Dysbiosis
Gene Components
Lactobacillus plantarum
Animal Behavior
Mutation
Probiotics
Lactobacillus
Drosophila melanogaster
Diptera
Homeostasis
Anti-Bacterial Agents
Bacteria
Phenotype
Gastrointestinal Microbiome

Keywords

  • demethylase
  • gut microbiome
  • H3K4me3
  • KDM5
  • social behavior

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

Cite this

Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance. / Chen, Kun; Luan, Xiaoting; Liu, Qisha; Wang, Jianwei; Chang, Xinxia; Snijders, Antoine M.; Mao, Jian Hua; Secombe, Julie; Dan, Zhou; Chen, Jian Huan; Wang, Zibin; Dong, Xiao; Qiu, Chen; Chang, Xiaoai; Zhang, Dong; Celniker, Susan E.; Liu, Xingyin.

In: Cell Host and Microbe, Vol. 25, No. 4, 10.04.2019, p. 537-552.e8.

Research output: Contribution to journalArticle

Chen, K, Luan, X, Liu, Q, Wang, J, Chang, X, Snijders, AM, Mao, JH, Secombe, J, Dan, Z, Chen, JH, Wang, Z, Dong, X, Qiu, C, Chang, X, Zhang, D, Celniker, SE & Liu, X 2019, 'Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance', Cell Host and Microbe, vol. 25, no. 4, pp. 537-552.e8. https://doi.org/10.1016/j.chom.2019.02.003
Chen, Kun ; Luan, Xiaoting ; Liu, Qisha ; Wang, Jianwei ; Chang, Xinxia ; Snijders, Antoine M. ; Mao, Jian Hua ; Secombe, Julie ; Dan, Zhou ; Chen, Jian Huan ; Wang, Zibin ; Dong, Xiao ; Qiu, Chen ; Chang, Xiaoai ; Zhang, Dong ; Celniker, Susan E. ; Liu, Xingyin. / Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance. In: Cell Host and Microbe. 2019 ; Vol. 25, No. 4. pp. 537-552.e8.
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abstract = "Loss-of-function mutations in the histone demethylases KDM5A, KDM5B, or KDM5C are found in intellectual disability (ID) and autism spectrum disorders (ASD) patients. Here, we use the model organism Drosophila melanogaster to delineate how KDM5 contributes to ID and ASD. We show that reducing KDM5 causes intestinal barrier dysfunction and changes in social behavior that correlates with compositional changes in the gut microbiota. Therapeutic alteration of the dysbiotic microbiota through antibiotic administration or feeding with a probiotic Lactobacillus strain partially rescues the behavioral, lifespan, and cellular phenotypes observed in kdm5-deficient flies. Mechanistically, KDM5 was found to transcriptionally regulate component genes of the immune deficiency (IMD) signaling pathway and subsequent maintenance of host-commensal bacteria homeostasis in a demethylase-dependent manner. Together, our study uses a genetic approach to dissect the role of KDM5 in the gut-microbiome-brain axis and suggests that modifying the gut microbiome may provide therapeutic benefits for ID and ASD patients. Mutations in members of the KDM5 gene family are found in intellectual disability and autism spectrum disorder patients. Chen et al. discovered that KDM5-microbiota interactions contribute to animal social behavior. Drosophila deficient in kdm5 display gut dysbiosis, abnormal social behavior, and aberrant immune activation, which Lactobacillus plantarum administration can improve.",
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AU - Chang, Xinxia

AU - Snijders, Antoine M.

AU - Mao, Jian Hua

AU - Secombe, Julie

AU - Dan, Zhou

AU - Chen, Jian Huan

AU - Wang, Zibin

AU - Dong, Xiao

AU - Qiu, Chen

AU - Chang, Xiaoai

AU - Zhang, Dong

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