Dorsomedial prefrontal cortex contribution to behavioral and nucleus accumbens neuronal responses to incentive cues

Akinori Ishikawa, Frederic Ambroggi, Saleem M. Nicola, Howard L. Fields

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Cue-elicited phasic changes in firing of nucleus accumbens (NAc) neurons can facilitate reward-seeking behavior. Here, we test the hypothesis that the medial prefrontal cortex (mPFC), which sends a dense glutamatergic projection to the NAc core, contributes to NAc neuronal firing responses to reward-predictive cues. Rats trained to perform an operant response to a cue for sucrose were implanted with recording electrodes in the core of the NAc and microinjection cannulas in the dorsal mPFC (dmPFC). The cue-evoked firing of NAc neurons was reduced by bilateral injection of GABAA and GABAB agonists into the dmPFC concomitant with loss of behavioral responding to the cue. In addition, unilateral dmPFC inactivation reduced ipsilateral cue excitations and contralateral cue inhibitions. These findings indicate that cue-evoked excitations and inhibitions of NAc core neurons depend on dmPFC projections to the NAc and that these phasic changes contribute to the behavioral response to reward-predictive cues.

Original languageEnglish (US)
Pages (from-to)5088-5098
Number of pages11
JournalJournal of Neuroscience
Volume28
Issue number19
DOIs
StatePublished - May 7 2008

Keywords

  • Anterior cingulate cortex
  • Discriminative stimulus
  • Nucleus accumbens core
  • Prelimbic cortex
  • Reward-seeking behavior
  • Ventral striatum

ASJC Scopus subject areas

  • Neuroscience(all)

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