Donor origin of multipotent adult progenitor cells in radiation chimeras

Morayma Reyes, Sheng Li, Jessica Foraker, En Kimura, Jeffrey S. Chamberlain

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Multipotent adult progenitor cells (MAPCs) are bone marrow-derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all 3 germinal layers: ectoderm, mesoderm, and endoderm. The origin of MAPCs within bone marrow is unknown. MAPCs are believed to be derived from the bone marrow stroma compartment as they are isolated within the adherent cell component. Numerous studies of bone marrow chimeras in the human and the mouse point to a host origin of bone marrow stromal cells. Mesenchymal stem cells (MSCs), which coexist with stromal cells, have also been proven to be of host origin after allogeneic bone marrow transplantation in numerous studies. We report here that following syngeneic bone marrow transplants into lethally irradiated C57BL6 mice, MAPCs are of donor origin.

Original languageEnglish (US)
Pages (from-to)3646-3649
Number of pages4
JournalBlood
Volume106
Issue number10
DOIs
Publication statusPublished - Nov 15 2005
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Reyes, M., Li, S., Foraker, J., Kimura, E., & Chamberlain, J. S. (2005). Donor origin of multipotent adult progenitor cells in radiation chimeras. Blood, 106(10), 3646-3649. https://doi.org/10.1182/blood-2004-12-4603