Donor origin of multipotent adult progenitor cells in radiation chimeras

Morayma Reyes Gil, Sheng Li, Jessica Foraker, En Kimura, Jeffrey S. Chamberlain

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Multipotent adult progenitor cells (MAPCs) are bone marrow-derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all 3 germinal layers: ectoderm, mesoderm, and endoderm. The origin of MAPCs within bone marrow is unknown. MAPCs are believed to be derived from the bone marrow stroma compartment as they are isolated within the adherent cell component. Numerous studies of bone marrow chimeras in the human and the mouse point to a host origin of bone marrow stromal cells. Mesenchymal stem cells (MSCs), which coexist with stromal cells, have also been proven to be of host origin after allogeneic bone marrow transplantation in numerous studies. We report here that following syngeneic bone marrow transplants into lethally irradiated C57BL6 mice, MAPCs are of donor origin.

Original languageEnglish (US)
Pages (from-to)3646-3649
Number of pages4
JournalBlood
Volume106
Issue number10
DOIs
StatePublished - Nov 15 2005
Externally publishedYes

Fingerprint

Radiation Chimera
Bone
Stem Cells
Bone Marrow
Radiation
Mesenchymal Stromal Cells
Stem cells
Endoderm
Ectoderm
Homologous Transplantation
Mesoderm
Cellular Structures
Stromal Cells
Bone Marrow Transplantation
Transplants
Tissue

ASJC Scopus subject areas

  • Hematology

Cite this

Reyes Gil, M., Li, S., Foraker, J., Kimura, E., & Chamberlain, J. S. (2005). Donor origin of multipotent adult progenitor cells in radiation chimeras. Blood, 106(10), 3646-3649. https://doi.org/10.1182/blood-2004-12-4603

Donor origin of multipotent adult progenitor cells in radiation chimeras. / Reyes Gil, Morayma; Li, Sheng; Foraker, Jessica; Kimura, En; Chamberlain, Jeffrey S.

In: Blood, Vol. 106, No. 10, 15.11.2005, p. 3646-3649.

Research output: Contribution to journalArticle

Reyes Gil, M, Li, S, Foraker, J, Kimura, E & Chamberlain, JS 2005, 'Donor origin of multipotent adult progenitor cells in radiation chimeras', Blood, vol. 106, no. 10, pp. 3646-3649. https://doi.org/10.1182/blood-2004-12-4603
Reyes Gil, Morayma ; Li, Sheng ; Foraker, Jessica ; Kimura, En ; Chamberlain, Jeffrey S. / Donor origin of multipotent adult progenitor cells in radiation chimeras. In: Blood. 2005 ; Vol. 106, No. 10. pp. 3646-3649.
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